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Hensley Lab

@scottehensley.bsky.social
9.3K followers 121 following 108 posts

dad, viral immunologist, professor

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Hensley Lab @scottehensley.bsky.social · 4h
@lhmoncla.bsky.social and I are happy to present Dr. Ort! Congrats Jordan!! #@ceirrnetwork.bsky.social trainee successfully defends his PhD!
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Hensley Lab @scottehensley.bsky.social · 30/09/2026
This is a really important development. It appears H1N1 cases are rising in the western part of the United States, and these viruses have a key HA substitution that @jbloomlab.bsky.social recently demonstrated is targeted by antibodies in young people. 1/4 www.kuow.org/health/2026-...
kuow.org
The flu has arrived early in Washington state
Flu cases are surging in Washington state, much sooner than when health officials usually expect the illness to peak in winter.
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Hensley Lab @scottehensley.bsky.social · 05/07/2026
Do you live in Philly? Has your cat been acting crazy? Well, it is likely this craziness is not due to H5N1 infection--but rather the fact that your cat is a cat. In this new preprint with @lhmoncla.bsky.social we find low H5N1 seroprevalence rates in Philly cats. www.biorxiv.org/content/10.6...
biorxiv.org
Clade 2.3.4.4b H5N1 influenza virus and SARS-CoV-2 seroprevalence among owned and feral cats in Philadelphia and surrounding communities
Clade 2.3.4.4b H5NX influenza viruses have spread widely in birds since 2020. In addition to causing disease in birds, these viruses have infected a variety of mammals, including humans. Clade 2.3.4.4...
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Madhu Pai, MD, PhD @madhupai.bsky.social · 04/06/2026
Karolinska Institutet KI is inviting applications for 21 Assistant Professor positions in medicine and health @ki.se ki.se/en/about-ki/...
ki.se
Assistant Professor recruitment programme 2026
Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...
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Hensley Lab @scottehensley.bsky.social · 19/05/2026
Publishing papers and receiving grants are important...but seeing your PhD student receive a 'thesis of the year' award at graduation is priceless! Congrats Grace! @cambupenn.bsky.social @ceirrnetwork.bsky.social
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Hensley Lab @scottehensley.bsky.social · 11/05/2026
Jordan's paper showing that immune history affects levels of cross-reactive H5N1 NA antibodies was just posted at Nature Communications. Congrats to Jordan and the team! See thread below when we originally posted on medRxiv... www.nature.com/articles/s41...
nature.com
Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history - Nature Communications
H5N1 avian influenza viruses have pandemic potential, yet antibody responses to their neuraminidase aren’t well studied. Here, the authors demonstrate that childhood exposure to H1N1 viruses enhances ...
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NBC News @nbcnews.com · 07/05/2026
New results published in the New England Journal of Medicine finds Moderna’s mRNA flu vaccine gave more protection against illness than the standard flu shot in a Phase 3 clinical trial.
nbcnews.to
Moderna’s mRNA flu vaccine more effective than standard shot in late-stage trial
An mRNA-based flu shot could make a huge difference in flu prevention, allowing scientists to pick a better strain match.
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Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 07/05/2026
The #hantavirus outbreak on the cruise ship off the coast of Africa is a serious public health event that needs to be handled properly. But if you are having #Covid flashbacks, put those worries to rest. The risk here is to people on the ship & their close contacts. www.statnews.com/2026/05/07/h...
statnews.com
Cruise ship hantavirus outbreak worries experts, though they discount pandemic fears
Scientists are worried that hantaviruses haven’t been as well studied as they ought to be, but not that the MV Hondius cruise ship is ground zero for the next pandemic.
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WHO @who.int · 06/05/2026
Swiss authorities have confirmed a case of #hantavirus identified in a passenger from the MV Hondius cruise ship. He had responded to an email from the ship’s operator informing the passengers of the health event, and presented himself to a hospital in Zurich, Switzerland, and is receiving care. 1️⃣
Update Hantavirus 6 May 2026
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Hensley Lab @scottehensley.bsky.social · 04/05/2026
This is not good. Most likely not human to human transmission but need to keep close eye on this. www.nbcnews.com/health/healt...
nbcnews.com
Cruise ship at center of suspected deadly hantavirus outbreak refused permission to dock
The cruise operator said in a statement that the ship may sail from Cape Verde to Las Palmas or Tenerife in the Canary Islands and dock there.
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WHO @who.int · 03/05/2026
WHO is aware of and supporting a public health event involving a cruise vessel sailing in the Atlantic Ocean.
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Hensley Lab @scottehensley.bsky.social · 27/04/2026
Check out our new study published today showing that HA head-reactive B cells primed by H3N2 infections in the 1990s can be recalled by contemporary pH1N1 viruses. A huge Penn-CEIRR effort, led by Grace Li from my lab. Congrats to Grace and team! www.cell.com/cell-host-mi...
cell.com
Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses
Li et al. isolated H1/H3 cross-reactive antibodies targeting a conserved epitope in the HA head. These antibodies were mostly found in people born in the 1990s and can be elicited in ferrets by sequen...
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Hensley Lab @scottehensley.bsky.social · 13/04/2026
We are recruiting 1-2 postdoctoral fellows to investigate the specificity of human anti-influenza virus antibodies, and to determine how these antibodies impact global antigenic drift of influenza viruses. Join our lab at Penn in Philly. Reach out if you are interested in applying! Please repost!
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Hensley Lab @scottehensley.bsky.social · 09/04/2026
Get your popcorn ready!
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Jon Cohen @cohenjon.bsky.social · 27/03/2026
H5N1 in dairy cows largely has disappeared from the news--a reflection of steeply declining detections. But it continues to circulate on dairies, and researchers continue to debate critical questions about how the virus moves between farms and within herds. www.science.org/content/arti...
science.org
Two years after it emerged, ‘cow flu’ is still circulating—and baffling scientists
Researchers still aren’t sure how H5N1 influenza spreads between cows and from farm to farm
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Hensley Lab @scottehensley.bsky.social · 05/03/2026
Holy cow! Our new study showing that H5 mRNA-LNP vaccines are safe and effective in lactating dairy cows is now posted on @biorxivpreprint.bsky.social! We found that our vaccine elicits protective responses in 2,000 pound dairy cows! 1/ www.biorxiv.org/content/10.6...
biorxiv.org
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Hensley Lab @scottehensley.bsky.social · 04/03/2026
Happy to see the peer-reviewed version of this manuscript published yesterday in NEJM-Evidence. @nejm.org evidence.nejm.org/doi/full/10....
evidence.nejm.org
Antibodies Elicited by the 2025–2026 Influenza Vaccine
A new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025–2026 influenza season. We sought to determine whether the 2025–2026...
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Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 02/03/2026
Stanley Plotkin had a major hand in the development of a number of vaccines in use today; he designed the rubella vaccine. He remembers the world before widespread use of vaccines & knows what's coming as vaccine policy is rewritten & vaccine confidence is eroded. www.statnews.com/2026/03/02/s...
statnews.com
A titan of vaccine development sees his field’s achievements slip away
Stanley Plotkin, the 93-year-old "godfather of vaccines," is watching his field’s achievements slip away.
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Hensley Lab @scottehensley.bsky.social · 22/02/2026
Our preprint examining the specificity of human antibodies that cross-react with subclade K H3N2 viruses was posted this morning on medRxiv. These studies have implications on what vaccine strains should be selected for next year’s influenza season. 1/ www.medrxiv.org/content/10.6...
medrxiv.org
Mapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccine
An H3N2 variant, named subclade K, continues to circulate widely during the 2025-2026 influenza season. This virus possesses a hemagglutinin (HA) protein that has eleven substitutions relative to the ...
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Bloom lab @jbloomlab.bsky.social · 20/02/2026
We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza. Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
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Brenda Goodman @reportergoodman.bsky.social · 16/01/2026
A very few times in my career, I've done an interview that stunned me so much that I've gotten off the phone and walked into furniture. This was one of them. I'm grateful to this mom for her courage and vulnerability in doing this interview. www.cnn.com/2026/01/16/h...
cnn.com
A 4-year-old died of flu complications. Her mother has a message for other parents | CNN
Four-year-old Ellie Rudd – who loved mud and getting dressed up and having dance parties with her brother and sisters – died January 6, after the flu and a co-infection with an adenovirus turned into ...
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Hensley Lab @scottehensley.bsky.social · 08/01/2026
“This isn’t perfect, but if you can decrease your chance of getting flu this year by fourfold, man, that’s a vaccine that I want.” www.cnn.com/2026/01/07/h...
cnn.com
Wondering if you should get a flu shot? Here’s what science says | CNN
Flu is making people miserable from coast to coast, thanks in large part to a new strain called subclade K.
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Hensley Lab @scottehensley.bsky.social · 07/01/2026
“Although it’s not a complete match with what’s circulating, this vaccine appears to have the capacity to produce antibodies that will likely provide protection.” www.nbcnews.com/health/healt...
nbcnews.com
How effective is the flu shot this year? New report shows promising results
While the new findings are encouraging, "vaccines won’t do any good if people don’t get them," one expert said.
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Hensley Lab @scottehensley.bsky.social · 07/01/2026
We find that subclade K viruses are antigenically advanced; however, this year's flu vaccine surprisingly elicited antibodies in many individuals that efficiently recognized these viruses. The implications are clear: go get this year’s vaccine if you haven’t already! www.medrxiv.org/content/10.6...
medrxiv.org
Antibodies elicited by the 2025-2026 influenza vaccine in humans
A new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025-2026 influenza season. In this report, we completed experiments to det...
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Hensley Lab @scottehensley.bsky.social · 24/12/2025
Nice in-depth story on immune memory by @amandabkeener.bsky.social in @nature.com. “If we can develop multivalent vaccines that have many different flu antigens in them, we can replace original antigenic sin with a blessing of induced immunity.” www.nature.com/articles/d41...
nature.com
Immunological sin: how a person’s earliest flu infections dictate life-long immunity
Researchers are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus.
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Hensley Lab @scottehensley.bsky.social · 18/12/2025
“There may be less of a vaccine mismatch than many people initially believed.” More on this very soon from our group...Go get your vaccine if you haven't already! www.nytimes.com/2025/12/17/w...
nytimes.com
New Variant Raises Concerns of Another Bad Flu Season
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Michela Locci @michelalocci.bsky.social · 16/12/2025
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
cell.com
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...
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BK. Titanji @boghuma.bsky.social · 04/12/2025
A picture is worth a 1000 words. The birth dose of hepatitis B vaccines in the USA eliminated perinatally acquired hepatitis B infection from over 20,000 cases a year before the vaccine was introduced to <20 cases a year. The gaslighting by the current members ACIP is obscene, unethical and cruel.
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BNO News (Health) @health.bnonews.com · 22/11/2025
BREAKING: Man from Washington state dies after being infected with H5N5 bird flu
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Hensley Lab @scottehensley.bsky.social · 20/11/2025
“If there’s ever a year to get a flu vaccine, this is the year.” Even in years with vaccine mismatches, the flu vaccine consistently prevents severe disease and hospitalizations. Now is the time to get a flu shot if you haven't already, because we will likely have a lot of flu activity this year.
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Hensley Lab @scottehensley.bsky.social · 14/11/2025
CDC FluView is back, and our fears look like reality. 50.8% of circulating H3N2 viruses belong to the 2a.3a.1-K subclade, which have 2 mutations in a very important antigenic site. Our own 2025-2026 vaccine immunogenicity data will be posted in the next couple of weeks. www.cdc.gov/fluview/surv...
cdc.gov
Weekly US Influenza Surveillance Report: Key Updates for Week 45, ending November 8, 2025
Seasonal influenza activity is low.
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Louise H. Moncla @lhmoncla.bsky.social · 12/11/2025
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
nature.com
Ecology and spread of the North American H5N1 epizootic - Nature
The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...
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Hensley Lab @scottehensley.bsky.social · 30/10/2025
CDC FluView hasn't been updated in a month, so I will start posting Philadelphia flu activity updates weekly. It is especially important to track flu in the US this year, since there are reports of a severe early flu season in parts of Asia. The PA department of health also has a nice website. 1/2
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Apoorva Mandavilli @apoorvanyt.bsky.social · 22/10/2025
After a quiet summer, the bird flu virus H5N1 is hitting poultry flocks hard in the run-up to the holidays — and in the midst of a federal government shutdown. w/ @emilyanthes.bsky.social (Gift article) www.nytimes.com/2025/10/22/h...
nytimes.com
Bird Flu Is Back
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Hensley Lab @scottehensley.bsky.social · 21/10/2025
Reports of severe flu cases in Hong Kong. If I was a politician, I would strengthen international collaborations to study infectious diseases in other countries. Now is a good time to get a seasonal flu vaccine in the US…there are signs we could have an early season. www.info.gov.hk/gia/general/...
info.gov.hk
CHP urges schoolchildren to promptly receive seasonal influenza vaccination as another severe paediatric influenza infection case reported
The Centre for Health Protection (CHP) of the Department of Health (DH) today (October 20) announced a case of severe paediatric influenza A infection. The CHP urged schools and parents...
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Hensley Lab @scottehensley.bsky.social · 16/10/2025
www.thedp.com/article/2025...
thedp.com
Penn rejects White House proposal for special funding treatment
With the decision, Penn becomes the third university to decline the offer.
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Louise H. Moncla @lhmoncla.bsky.social · 15/10/2025
Our lab's first paper is out! Led by Jordan Ort, we developed NextClade datasets that enable rapid H5 clade assignment via NextClade. We deployed these during the start of the H5 cattle outbreak, and we finally published the paper in Virus Evolution academic.oup.com/ve/article/1...
academic.oup.com
Development of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment
Abstract. The 2022 panzootic of highly pathogenic avian influenza (HPAI) A(H5) viruses has led to unprecedented transmission to multiple mammalian species.
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Hensley Lab @scottehensley.bsky.social · 26/09/2025
I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/ www.medrxiv.org/content/10.1...
medrxiv.org
Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses
Influenza virus cross-subtype antibodies targeting the hemagglutinin (HA) head are rare. Here, we found that a large proportion of monoclonal antibodies (mAbs) isolated from individuals immunized with...
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Lieutenant Governor Austin Davis @lgaustindavis.bsky.social · 19/09/2025
Pennsylvania has now joined with our other northeastern states to create the Northeast Public Health Collaborative to protect public health, provide vaccine recommendations and share expertise.   Protecting public health only works when we’re united.
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Demetre Daskalakis @drdemetre.bsky.social · 19/09/2025
In June, an ACIP member said that 250 pediatric flu deaths were no big deal. Maybe today we will find out that a handful of hepatitis B related cancers, transplants, and deaths are also not a big deal to them either. Welcome to the new public health. We are aligned to a manifesto, not science.
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Bloom lab @jbloomlab.bsky.social · 08/09/2025
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains Data can inform vaccine selection & evolutionary/epidemiological modeling www.biorxiv.org/content/10.1...
biorxiv.org
Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025
The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...
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Hensley Lab @scottehensley.bsky.social · 08/09/2025
A few months ago, when asked if his Nobel prize changed his science, David Baltimore said "I got into science because I love data. And the only thing I really care about in my life is data. And for that reason I didn't stop doing science because I won an award." www.youtube.com/watch?v=XqUK...
youtube.com
CSHL Keynote, Dr. David Baltimore, Caltech
YouTube video by CSHL Leading Strand
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Hensley Lab @scottehensley.bsky.social · 04/09/2025
A new study led by @cambupenn.bsky.social Jordan Ort in my lab was posted on medRxiv. We found that humans infected with H1N1 viruses in childhood have high levels of Abs that cross-react to the NA of H5N1 viruses...decades after their childhood H1N1 infections. 1/ www.medrxiv.org/content/10.1...
medrxiv.org
Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history
H5N1 highly pathogenic avian influenza viruses have spread globally and pose a risk for a human pandemic. Prior studies suggest that early life exposures to group 1 influenza viruses (H1N1 and H2N2) p...
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Hensley Lab @scottehensley.bsky.social · 13/08/2025
Looks like one of our ‘imprinting’ papers was cited in the HHS data package, despite our conclusion that people receiving an ancestral mRNA vaccine were better at producing antibodies against variants compared to unvaccinated people.
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Hensley Lab @scottehensley.bsky.social · 11/08/2025
“Dr. Bhattacharya might not realize that many human vaccines are based on live attenuated viruses, where we similarly cannot definitively quantify antigen amounts produced in recipients. The mRNA and live attenuated vaccine platforms have both proven to be safe and effective in clinical studies.”
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Hensley Lab @scottehensley.bsky.social · 06/08/2025
Science and health shouldn’t be wrapped up into politics. This leaves the US woefully unprepared for the next pandemic.
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Gregg Gonsalves @gregggonsalves.bsky.social · 26/07/2025
The former NIH director on the catastrophe unfolding for American research. youtu.be/lW9c6t4potU
youtu.be
A Scientific Brain Drain Has Followed Trump’s Gutting Of The NIH - Dr. Francis Collins
YouTube video by The Late Show with Stephen Colbert
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Dr. Tom Frieden @drtomfrieden.bsky.social · 10/06/2025
Dissolving ACIP is an absolute mistake. We need accurate information—not fringe theories—guiding government recommendations on which vaccines to give which people.
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Ed Belongia MD @belongia.bsky.social · 09/06/2025
Canada's National Advisory Committee on Immunization (NACI) is now the definitive source for evidence-based vaccine recommendations in North America. www.canada.ca/en/public-he...
canada.ca
National Advisory Committee on Immunization (NACI): Statements and publications - Canada.ca
The National Advisory Committee on Immunization (NACI) makes recommendations for the use of vaccines currently or newly approved for use in humans in Canada, including the identification of groups at ...
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Hensley Lab @scottehensley.bsky.social · 09/06/2025
Unbelievable. Truly unbelievable.
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