Hensley Lab @scottehensley.bsky.social · 4h@lhmoncla.bsky.social and I are happy to present Dr. Ort! Congrats Jordan!! #@ceirrnetwork.bsky.social trainee successfully defends his PhD! 1170
Hensley Lab @scottehensley.bsky.social · 30/09/2026This is a really important development. It appears H1N1 cases are rising in the western part of the United States, and these viruses have a key HA substitution that @jbloomlab.bsky.social recently demonstrated is targeted by antibodies in young people. 1/4 www.kuow.org/health/2026-...kuow.orgThe flu has arrived early in Washington stateFlu cases are surging in Washington state, much sooner than when health officials usually expect the illness to peak in winter. 22820
Hensley Lab @scottehensley.bsky.social · 05/07/2026Do you live in Philly? Has your cat been acting crazy? Well, it is likely this craziness is not due to H5N1 infection--but rather the fact that your cat is a cat. In this new preprint with @lhmoncla.bsky.social we find low H5N1 seroprevalence rates in Philly cats. www.biorxiv.org/content/10.6...biorxiv.orgClade 2.3.4.4b H5N1 influenza virus and SARS-CoV-2 seroprevalence among owned and feral cats in Philadelphia and surrounding communitiesClade 2.3.4.4b H5NX influenza viruses have spread widely in birds since 2020. In addition to causing disease in birds, these viruses have infected a variety of mammals, including humans. Clade 2.3.4.4... 1175
Reposted by Hensley LabMadhu Pai, MD, PhD @madhupai.bsky.social · 04/06/2026Karolinska Institutet KI is inviting applications for 21 Assistant Professor positions in medicine and health @ki.se ki.se/en/about-ki/...ki.seAssistant Professor recruitment programme 2026Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo... 13036
Hensley Lab @scottehensley.bsky.social · 19/05/2026Publishing papers and receiving grants are important...but seeing your PhD student receive a 'thesis of the year' award at graduation is priceless! Congrats Grace! @cambupenn.bsky.social @ceirrnetwork.bsky.social 0222
Hensley Lab @scottehensley.bsky.social · 11/05/2026Jordan's paper showing that immune history affects levels of cross-reactive H5N1 NA antibodies was just posted at Nature Communications. Congrats to Jordan and the team! See thread below when we originally posted on medRxiv... www.nature.com/articles/s41...nature.comCross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history - Nature CommunicationsH5N1 avian influenza viruses have pandemic potential, yet antibody responses to their neuraminidase aren’t well studied. Here, the authors demonstrate that childhood exposure to H1N1 viruses enhances ... 0155
Reposted by Hensley LabNBC News @nbcnews.com · 07/05/2026New results published in the New England Journal of Medicine finds Moderna’s mRNA flu vaccine gave more protection against illness than the standard flu shot in a Phase 3 clinical trial.nbcnews.toModerna’s mRNA flu vaccine more effective than standard shot in late-stage trialAn mRNA-based flu shot could make a huge difference in flu prevention, allowing scientists to pick a better strain match. 8361140
Reposted by Hensley LabHelen Branswell 🇨🇦 @helenbranswell.bsky.social · 07/05/2026The #hantavirus outbreak on the cruise ship off the coast of Africa is a serious public health event that needs to be handled properly. But if you are having #Covid flashbacks, put those worries to rest. The risk here is to people on the ship & their close contacts. www.statnews.com/2026/05/07/h...statnews.comCruise ship hantavirus outbreak worries experts, though they discount pandemic fearsScientists are worried that hantaviruses haven’t been as well studied as they ought to be, but not that the MV Hondius cruise ship is ground zero for the next pandemic. 818271
Reposted by Hensley LabWHO @who.int · 06/05/2026Swiss authorities have confirmed a case of #hantavirus identified in a passenger from the MV Hondius cruise ship. He had responded to an email from the ship’s operator informing the passengers of the health event, and presented himself to a hospital in Zurich, Switzerland, and is receiving care. 1️⃣ 8206102
Hensley Lab @scottehensley.bsky.social · 04/05/2026This is not good. Most likely not human to human transmission but need to keep close eye on this. www.nbcnews.com/health/healt...nbcnews.comCruise ship at center of suspected deadly hantavirus outbreak refused permission to dockThe cruise operator said in a statement that the ship may sail from Cape Verde to Las Palmas or Tenerife in the Canary Islands and dock there. 0133
Reposted by Hensley LabWHO @who.int · 03/05/2026WHO is aware of and supporting a public health event involving a cruise vessel sailing in the Atlantic Ocean. 28961254
Hensley Lab @scottehensley.bsky.social · 27/04/2026Check out our new study published today showing that HA head-reactive B cells primed by H3N2 infections in the 1990s can be recalled by contemporary pH1N1 viruses. A huge Penn-CEIRR effort, led by Grace Li from my lab. Congrats to Grace and team! www.cell.com/cell-host-mi...cell.comChildhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza virusesLi et al. isolated H1/H3 cross-reactive antibodies targeting a conserved epitope in the HA head. These antibodies were mostly found in people born in the 1990s and can be elicited in ferrets by sequen... 1184
Hensley Lab @scottehensley.bsky.social · 13/04/2026We are recruiting 1-2 postdoctoral fellows to investigate the specificity of human anti-influenza virus antibodies, and to determine how these antibodies impact global antigenic drift of influenza viruses. Join our lab at Penn in Philly. Reach out if you are interested in applying! Please repost! 01820
Reposted by Hensley LabJon Cohen @cohenjon.bsky.social · 27/03/2026H5N1 in dairy cows largely has disappeared from the news--a reflection of steeply declining detections. But it continues to circulate on dairies, and researchers continue to debate critical questions about how the virus moves between farms and within herds. www.science.org/content/arti...science.orgTwo years after it emerged, ‘cow flu’ is still circulating—and baffling scientistsResearchers still aren’t sure how H5N1 influenza spreads between cows and from farm to farm 23921
Hensley Lab @scottehensley.bsky.social · 05/03/2026Holy cow! Our new study showing that H5 mRNA-LNP vaccines are safe and effective in lactating dairy cows is now posted on @biorxivpreprint.bsky.social! We found that our vaccine elicits protective responses in 2,000 pound dairy cows! 1/ www.biorxiv.org/content/10.6...biorxiv.org 37919
Hensley Lab @scottehensley.bsky.social · 04/03/2026Happy to see the peer-reviewed version of this manuscript published yesterday in NEJM-Evidence. @nejm.org evidence.nejm.org/doi/full/10....evidence.nejm.orgAntibodies Elicited by the 2025–2026 Influenza VaccineA new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025–2026 influenza season. We sought to determine whether the 2025–2026... 03912
Reposted by Hensley LabHelen Branswell 🇨🇦 @helenbranswell.bsky.social · 02/03/2026Stanley Plotkin had a major hand in the development of a number of vaccines in use today; he designed the rubella vaccine. He remembers the world before widespread use of vaccines & knows what's coming as vaccine policy is rewritten & vaccine confidence is eroded. www.statnews.com/2026/03/02/s...statnews.comA titan of vaccine development sees his field’s achievements slip awayStanley Plotkin, the 93-year-old "godfather of vaccines," is watching his field’s achievements slip away. 5277116
Hensley Lab @scottehensley.bsky.social · 22/02/2026Our preprint examining the specificity of human antibodies that cross-react with subclade K H3N2 viruses was posted this morning on medRxiv. These studies have implications on what vaccine strains should be selected for next year’s influenza season. 1/ www.medrxiv.org/content/10.6...medrxiv.orgMapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccineAn H3N2 variant, named subclade K, continues to circulate widely during the 2025-2026 influenza season. This virus possesses a hemagglutinin (HA) protein that has eleven substitutions relative to the ... 23422
Reposted by Hensley LabBloom lab @jbloomlab.bsky.social · 20/02/2026We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza. Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine. 17637
Reposted by Hensley LabBrenda Goodman @reportergoodman.bsky.social · 16/01/2026A very few times in my career, I've done an interview that stunned me so much that I've gotten off the phone and walked into furniture. This was one of them. I'm grateful to this mom for her courage and vulnerability in doing this interview. www.cnn.com/2026/01/16/h...cnn.comA 4-year-old died of flu complications. Her mother has a message for other parents | CNNFour-year-old Ellie Rudd – who loved mud and getting dressed up and having dance parties with her brother and sisters – died January 6, after the flu and a co-infection with an adenovirus turned into ... 0113
Hensley Lab @scottehensley.bsky.social · 08/01/2026“This isn’t perfect, but if you can decrease your chance of getting flu this year by fourfold, man, that’s a vaccine that I want.” www.cnn.com/2026/01/07/h...cnn.comWondering if you should get a flu shot? Here’s what science says | CNNFlu is making people miserable from coast to coast, thanks in large part to a new strain called subclade K. 0163
Hensley Lab @scottehensley.bsky.social · 07/01/2026“Although it’s not a complete match with what’s circulating, this vaccine appears to have the capacity to produce antibodies that will likely provide protection.” www.nbcnews.com/health/healt...nbcnews.comHow effective is the flu shot this year? New report shows promising resultsWhile the new findings are encouraging, "vaccines won’t do any good if people don’t get them," one expert said. 0134
Hensley Lab @scottehensley.bsky.social · 07/01/2026We find that subclade K viruses are antigenically advanced; however, this year's flu vaccine surprisingly elicited antibodies in many individuals that efficiently recognized these viruses. The implications are clear: go get this year’s vaccine if you haven’t already! www.medrxiv.org/content/10.6...medrxiv.orgAntibodies elicited by the 2025-2026 influenza vaccine in humansA new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025-2026 influenza season. In this report, we completed experiments to det... 16842
Hensley Lab @scottehensley.bsky.social · 24/12/2025Nice in-depth story on immune memory by @amandabkeener.bsky.social in @nature.com. “If we can develop multivalent vaccines that have many different flu antigens in them, we can replace original antigenic sin with a blessing of induced immunity.” www.nature.com/articles/d41...nature.comImmunological sin: how a person’s earliest flu infections dictate life-long immunityResearchers are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus. 0166
Hensley Lab @scottehensley.bsky.social · 18/12/2025“There may be less of a vaccine mismatch than many people initially believed.” More on this very soon from our group...Go get your vaccine if you haven't already! www.nytimes.com/2025/12/17/w...nytimes.comNew Variant Raises Concerns of Another Bad Flu Season 0188
Reposted by Hensley LabMichela Locci @michelalocci.bsky.social · 16/12/2025I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...cell.comDistinct components of mRNA vaccines cooperate to instruct efficient germinal center responsesThis study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de... 54919
Reposted by Hensley LabBK. Titanji @boghuma.bsky.social · 04/12/2025A picture is worth a 1000 words. The birth dose of hepatitis B vaccines in the USA eliminated perinatally acquired hepatitis B infection from over 20,000 cases a year before the vaccine was introduced to <20 cases a year. The gaslighting by the current members ACIP is obscene, unethical and cruel. 8284161
Reposted by Hensley LabBNO News (Health) @health.bnonews.com · 22/11/2025BREAKING: Man from Washington state dies after being infected with H5N5 bird flu 417677
Hensley Lab @scottehensley.bsky.social · 20/11/2025“If there’s ever a year to get a flu vaccine, this is the year.” Even in years with vaccine mismatches, the flu vaccine consistently prevents severe disease and hospitalizations. Now is the time to get a flu shot if you haven't already, because we will likely have a lot of flu activity this year. 0137
Hensley Lab @scottehensley.bsky.social · 14/11/2025CDC FluView is back, and our fears look like reality. 50.8% of circulating H3N2 viruses belong to the 2a.3a.1-K subclade, which have 2 mutations in a very important antigenic site. Our own 2025-2026 vaccine immunogenicity data will be posted in the next couple of weeks. www.cdc.gov/fluview/surv...cdc.govWeekly US Influenza Surveillance Report: Key Updates for Week 45, ending November 8, 2025Seasonal influenza activity is low. 22911
Reposted by Hensley LabLouise H. Moncla @lhmoncla.bsky.social · 12/11/2025Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...nature.comEcology and spread of the North American H5N1 epizootic - NatureThe panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril... 614065
Hensley Lab @scottehensley.bsky.social · 30/10/2025CDC FluView hasn't been updated in a month, so I will start posting Philadelphia flu activity updates weekly. It is especially important to track flu in the US this year, since there are reports of a severe early flu season in parts of Asia. The PA department of health also has a nice website. 1/2 11910
Reposted by Hensley LabApoorva Mandavilli @apoorvanyt.bsky.social · 22/10/2025After a quiet summer, the bird flu virus H5N1 is hitting poultry flocks hard in the run-up to the holidays — and in the midst of a federal government shutdown. w/ @emilyanthes.bsky.social (Gift article) www.nytimes.com/2025/10/22/h...nytimes.comBird Flu Is Back 1714873
Hensley Lab @scottehensley.bsky.social · 21/10/2025Reports of severe flu cases in Hong Kong. If I was a politician, I would strengthen international collaborations to study infectious diseases in other countries. Now is a good time to get a seasonal flu vaccine in the US…there are signs we could have an early season. www.info.gov.hk/gia/general/...info.gov.hkCHP urges schoolchildren to promptly receive seasonal influenza vaccination as another severe paediatric influenza infection case reportedThe Centre for Health Protection (CHP) of the Department of Health (DH) today (October 20) announced a case of severe paediatric influenza A infection. The CHP urged schools and parents... 02210
Hensley Lab @scottehensley.bsky.social · 16/10/2025www.thedp.com/article/2025...thedp.comPenn rejects White House proposal for special funding treatmentWith the decision, Penn becomes the third university to decline the offer. 0132
Reposted by Hensley LabLouise H. Moncla @lhmoncla.bsky.social · 15/10/2025Our lab's first paper is out! Led by Jordan Ort, we developed NextClade datasets that enable rapid H5 clade assignment via NextClade. We deployed these during the start of the H5 cattle outbreak, and we finally published the paper in Virus Evolution academic.oup.com/ve/article/1...academic.oup.comDevelopment of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignmentAbstract. The 2022 panzootic of highly pathogenic avian influenza (HPAI) A(H5) viruses has led to unprecedented transmission to multiple mammalian species. 33912
Hensley Lab @scottehensley.bsky.social · 26/09/2025I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/ www.medrxiv.org/content/10.1...medrxiv.orgChildhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza virusesInfluenza virus cross-subtype antibodies targeting the hemagglutinin (HA) head are rare. Here, we found that a large proportion of monoclonal antibodies (mAbs) isolated from individuals immunized with... 23515
Reposted by Hensley LabLieutenant Governor Austin Davis @lgaustindavis.bsky.social · 19/09/2025Pennsylvania has now joined with our other northeastern states to create the Northeast Public Health Collaborative to protect public health, provide vaccine recommendations and share expertise. Protecting public health only works when we’re united. 2185
Reposted by Hensley LabDemetre Daskalakis @drdemetre.bsky.social · 19/09/2025In June, an ACIP member said that 250 pediatric flu deaths were no big deal. Maybe today we will find out that a handful of hepatitis B related cancers, transplants, and deaths are also not a big deal to them either. Welcome to the new public health. We are aligned to a manifesto, not science. 623180
Reposted by Hensley LabBloom lab @jbloomlab.bsky.social · 08/09/2025In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains Data can inform vaccine selection & evolutionary/epidemiological modeling www.biorxiv.org/content/10.1...biorxiv.orgNear real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again... 16035
Hensley Lab @scottehensley.bsky.social · 08/09/2025A few months ago, when asked if his Nobel prize changed his science, David Baltimore said "I got into science because I love data. And the only thing I really care about in my life is data. And for that reason I didn't stop doing science because I won an award." www.youtube.com/watch?v=XqUK...youtube.comCSHL Keynote, Dr. David Baltimore, CaltechYouTube video by CSHL Leading Strand 0163
Hensley Lab @scottehensley.bsky.social · 04/09/2025A new study led by @cambupenn.bsky.social Jordan Ort in my lab was posted on medRxiv. We found that humans infected with H1N1 viruses in childhood have high levels of Abs that cross-react to the NA of H5N1 viruses...decades after their childhood H1N1 infections. 1/ www.medrxiv.org/content/10.1...medrxiv.orgCross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune historyH5N1 highly pathogenic avian influenza viruses have spread globally and pose a risk for a human pandemic. Prior studies suggest that early life exposures to group 1 influenza viruses (H1N1 and H2N2) p... 1215
Hensley Lab @scottehensley.bsky.social · 13/08/2025Looks like one of our ‘imprinting’ papers was cited in the HHS data package, despite our conclusion that people receiving an ancestral mRNA vaccine were better at producing antibodies against variants compared to unvaccinated people. 15132
Hensley Lab @scottehensley.bsky.social · 11/08/2025“Dr. Bhattacharya might not realize that many human vaccines are based on live attenuated viruses, where we similarly cannot definitively quantify antigen amounts produced in recipients. The mRNA and live attenuated vaccine platforms have both proven to be safe and effective in clinical studies.” 0358
Hensley Lab @scottehensley.bsky.social · 06/08/2025Science and health shouldn’t be wrapped up into politics. This leaves the US woefully unprepared for the next pandemic. 0265
Reposted by Hensley LabGregg Gonsalves @gregggonsalves.bsky.social · 26/07/2025The former NIH director on the catastrophe unfolding for American research. youtu.be/lW9c6t4potUyoutu.beA Scientific Brain Drain Has Followed Trump’s Gutting Of The NIH - Dr. Francis CollinsYouTube video by The Late Show with Stephen Colbert 011552
Reposted by Hensley LabDr. Tom Frieden @drtomfrieden.bsky.social · 10/06/2025Dissolving ACIP is an absolute mistake. We need accurate information—not fringe theories—guiding government recommendations on which vaccines to give which people. 8279123
Reposted by Hensley LabEd Belongia MD @belongia.bsky.social · 09/06/2025Canada's National Advisory Committee on Immunization (NACI) is now the definitive source for evidence-based vaccine recommendations in North America. www.canada.ca/en/public-he...canada.caNational Advisory Committee on Immunization (NACI): Statements and publications - Canada.caThe National Advisory Committee on Immunization (NACI) makes recommendations for the use of vaccines currently or newly approved for use in humans in Canada, including the identification of groups at ... 05132