Reposted by Joel Rivera-CardonaMargaret Dedloff @mdedloff.bsky.social · 27/01/2026I'm so proud of this work and how it all came together! 184
Reposted by Joel Rivera-CardonaChris Brooke @christopherbrooke.bsky.social · 01/01/2026Happy to see @joelrc.bsky.social's paper identifying cellular heterogeneity in basal OASL expression as a major determinant of interferon induction during influenza virus infection out in its final form: www.pnas.org/doi/10.1073/... Happy new year, hope everyone's 2026 is better than 2025!pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 02111
Reposted by Joel Rivera-CardonaChris Brooke @christopherbrooke.bsky.social · 18/03/2025Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection: www.biorxiv.org/content/10.1...biorxiv.orgIntrinsic OASL expression licenses interferon induction during influenza A virus infectionEffective control of viral infection requires rapid induction of the innate immune response, especially the type I and type III interferon (IFN) systems. Despite the critical role of IFN induction in ... 35522
Reposted by Joel Rivera-CardonaChris Brooke @christopherbrooke.bsky.social · 12/12/2024@joelrc.bsky.social 's paper on differences between the seasonal H1N1 and H3N2 lineages in their relative capacity to antagonize IFN induction and signaling at the single cell level is out now in PLOS Pathogens: journals.plos.org/plospathogen...journals.plos.orgSeasonal influenza a virus lineages exhibit divergent abilities to antagonize interferon induction and signalingAuthor summary Successful replication and transmission of influenza A viruses (IAVs) requires effective subversion of the innate immune response. We developed a new single cell method to examine the i... 03111
