Lung anthelmintic responses during hookworm infection are regulated by skin-derived γδ T cells.

Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor dependence that underpins their conserved roles in ...

Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor dependence that underpins their conserved roles in ...

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, which is likely caused by the epigene…

A machine-learning algorithm, PreGame, is developed to identify tumour-reactive γδ T cells from single-cell CITE sequencing data, and expansion of this cell population can be used as a biomarker of th...

Signal Transduction and Targeted Therapy - Interleukin-1 receptor-associated kinase 1 controls chemoresistance and immuno-killing in non-small cell lung cancer

Fulford et al. show an interaction between butyrophilin (BTN) 3A1 and the δ chain of the Vγ9Vδ2+ T cell receptor. These data suggest that BTN3A1, along with BTN2A1, is sufficient to mediate Vγ9Vδ2+ T ...

Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduce

Researchers identify interleukin-17A+ γδ T cells as key immune defenders against non-tuberculous mycobacteria infections, demonstrating their ability to protect hosts when IFNγ immunity is impaired.

Kishikawa et al. demonstrate that periodontitis induces anxiety-like behavior and cognitive dysfunction through IL-17A-producing γδ T cells that migrate from the cervical lymph nodes to the brain via ...

Immunology; Omics

γδ T cells are an important component of local immune surveillance. This Review discusses their role in colorectal cancer and hepatocellular carcinoma development and provides a detailed overview of t...

Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized ‘squares of discovery’ in which deep...

Key Points. Higher proportions of CD4+ T, Vδ2T and MAIT cells expressing CD69 can identify HSCT recipients at risk of HCMV reactivation.EM CD8+T, TIM-3+CD8

The intestinal barrier harbors numerous intraepithelial lymphocytes (IELs) that promote tissue integrity and whose dysfunction contributes to disease. Earley et al. studied the G-protein coupled recep...

Abstract. Background: We aimed to identify circulating and tumor immune features predictive of oncological outcomes under Atezolizumab-Bevacizumab (AtezoBev) therapy for hepatocellular carcinoma (HCC)...

The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophag...

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...

In this Review, the authors describe γδ T cells, mucosal-associated invariant T cells, natural killer T cells and CD4 and CD8 double-positive or double-negative T cells in bladder, renal cell and...

Intestinal γδ T cells undergo temporal immunological maturation during neonatal, postnatal, and adult life.

BTNL3 and BTNL8 are butyrophilin-like receptors that selectively regulate intestinal Vγ4+ T cells, yet the underlying activation mechanism has remained elusive. Dong et al. reveal that BTNL3-BTNL8 for...

The first Japanese scientist to win the Nobel Prize in Physiology or Medicine, he went on to discover how memories are stored, advancing understanding of how the brain works.

ALT: The One: There Can Be Only One

ALT: The One: There Can Be Only One

Abstract. Gamma delta (γδ) T cells emerge early during human gestation and are uniquely equipped to protect the fetus and infant following infection, due t

Of the three classes of lymphocytes that constitute the adaptive immune system, γδT cells are the only class for which the principles of antigen recognition remain enigmatic. Although endogenous γδT c...

The importance of γδ T cells in cancer, as defenders against tumorigenesis, was established more than 2 decades ago. Since that time, research using mouse models of cancer has brought to light a nonun...

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...

PURPOSEWe developed a novel approach to treat newly diagnosed glioblastoma (GBM) using genetically modified gamma-delta (γδ) T cells following the forced upregulation of stress-associated targets on t...

Patients with primary sclerosing cholangitis often manifest colon inflammation similar to ulcerative colitis (PSC-UC), but it is nevertheless pathologically distinct from conventional UC. Here the aut...

Human cutaneous γδ T cells infiltrate human cutaneous squamous cell carcinoma xenografts and exert potent antitumor effects.

ALT: Cakejumper Pointing Down

IL-17A–producing γδ T cells infiltrate the brain via CXCL16 and drive ASD-like behaviors in a genetic mouse model.