The industry’s approach to safety will guarantee more failures unless something changes.

Shirdhankar et al. establish a method to record from single neurons in the brain of African mole-rats while they are head-fixed or freely moving, performing natural behaviors. The method allows the study of sensory perception and neural adaptations of these strictly subterranean rodents, well known for their longevity, cancer resistance, and magnetic sense.

Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...

Researchers in the field are right to focus on biosafety, ethics and the involvement of patient groups and the public.

The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy

His State of the Force address was a partisan disgrace—with a few good ideas buried in it.

Integrating genome-wide maps of chromatin accessibility and sequence conservation provides an accessible low-cost approach for identifying cis-regulatory elements in large genomes, validated in the em...

Sequencing of species that can be cultured in the laboratory results in a bias in taxon sampling. This study uses cost-effective, amplification-free, low-input sequencing methods to assemble genomes…

Their whirring wings and bright patterns help keep them safe from birds, British study finds

A diet–microbiome–host axis strengthens mucosal immune defences and reinforces host–microbiota mutualism.

Many decisions require maintaining beliefs across multiple levels of representation, from sampling and integrating information to forming action plans. To elucidate these processes and reveal the neur...

Abstract. Body size is an iconic trait in quantitative genetics. For species with indeterminate growth however, growth curve, a function-valued trait, is t

Opinion | AI can replace each part of the scientific process, leaving the enterprise recognizable but devoid of human judgment.

There's nothing like doing science with your back against the wall. A rising star in her field, Nora Dunnahaldey is trying to get back on her feet after the death of her husband and the violent backla...

Single stranded RNA (ssRNA) and single stranded DNA (ssDNA) bacteriophages represent a key component of the global virome, yet the host genetic networks supporting their infection cycles remain poorly...

The superficial similarities between the U.S. and its closest friend are likely driving much of the president’s vitriol.

An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

Brain imaging across more than 1,200 people identifies two reproducible reward profiles, one tuned to cues and one to outcomes. The two profiles respond in opposite ways to dopamine-blocking drugs, an...

This study identifies oligodendrocytes as active contributors to cognitive decline in aging, by leveraging a unique human brain bank with more than 70 years of associated cognitive data combined with ...

Despite seemingly low levels of molybdenum (Mo)/tungsten (W) in the Earth’s ancient oceans, these metals play central roles in driving modern biogeochemical cycles. Klos et al. used phylogenomic appro...

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...