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C. Brandon Ogbunu

@cbo.bsky.social
3.8K followers 324 following 364 posts

Scientist + Humanist + Pugilist. "Tip your hat; pop the chain; short Joe Louis; then wipe his nose with the hook. It's that simple." (c) Brother Naazim Richardson linktr.ee/chike98

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Reposted by C. Brandon Ogbunu
Carl Zimmer @carlzimmer.com · 28/09/2026
The human genome is part virus. And here's a virus that's part human, having picked up a human gene about 100,000 years ago. My story here: nyti.ms/4hRKNPC
nyti.ms
This Virus Stole a Human Gene and Won’t Let Go of It (Gift Article)
Scientists have found a human gene lurking in a virus that causes skin infections. It may be using our own DNA to infect us.
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C. Brandon Ogbunu @cbo.bsky.social · 27/09/2026
In my latest for @undark.org, I compare AI adoption in science to the Ship of Theseus: "If you swap out every wooden plank on a ship over time, is it still the same vessel?" I argue that science derives authority from something more than data generation + publication. undark.org/2026/09/25/o...
undark.org
AI Presents Science with a ‘Ship of Theseus’ Problem
Opinion | AI can replace each part of the scientific process, leaving the enterprise recognizable but devoid of human judgment.
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Paul Smaldino @psmaldino.bsky.social · 27/09/2026
I just gave a talk on interdisciplinary yesterday that features a call for interdisciplinary people and not just diverse teams of disciplinary types. Today I read this essay with delight. Viva antedisciplinarity. journals.plos.org/ploscompbiol...
journals.plos.org
“Antedisciplinary” Science
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C. Brandon Ogbunu @cbo.bsky.social · 24/09/2026
Incredibly honored to be in conversation with someone I have long admired from afar.
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Brian J. Enquist @bjenquist.bsky.social · 23/09/2026
A good reminder "Data science" isn't Science..."Without models, mathematical or conceptual, data are just noise...science advances only if it can provide explanations...there is an area where petabytes of information can be used...But don't call it science" link.springer.com/article/10.1... 🧪🌐
link.springer.com
The end of theory in science? - EMBO Reports
EMBO Reports -
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C. Brandon Ogbunu @cbo.bsky.social · 23/09/2026
Oh snap The body temperature of Tyrannosaurus rex | Science Advances www.science.org/doi/10.1126/...
science.org
The body temperature of Tyrannosaurus rex
Despite an extensive history of study, quantitative constraints on the thermophysiology of Tyrannosaurus rex remain limited. Here, we derive a thermodynamically based determination of T. rex body temp...
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Philip Ball @philipcball.bsky.social · 21/09/2026
This Friday I will be in Copenhagen for a discussion with @cbo.bsky.social about how to broaden the scope of science communication. I'm so looking forward to it. globalhumanities.ku.dk/events/2026/...
globalhumanities.ku.dk
Science Communication: The Manhattan Project of the 21st Century
Talks with Professor Brandon Ogbunu from Yale University and UK Science Writer Philip Ball.
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Botanical Society of America @botsocamerica.bsky.social · 14/09/2026
🌿 Congratulations to Dr. Jenn Coughlan (Yale University), recipient of the 2026 BSA Emerging Leader Award! We're honored to recognize them as a rising star in our community. 👏 Learn more at www.botany.org (click Awards). #BSA2026AwardsBlitz #IamaBotanist #PlantPeopleFTW
A portrait of Jennifer Coughlan wearing dark-framed glasses and a navy shirt patterned with cranes, pineapples, and blue flowers, smiling in front of a sunlit brick wall. The text reads: "Botanical Society of America 2026 Emerging Leader Award, Jennifer Coughlan, Yale University." A QR code and the text "Learn more about the Emerging Leader Award here!" appear at the bottom, along with the Botanical Society of America logo. The graphic has a border of pale green agave leaves.
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C. Brandon Ogbunu @cbo.bsky.social · 14/09/2026
"How would you describe your career in science?"
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Reposted by C. Brandon Ogbunu
Philip Ball @philipcball.bsky.social · 12/09/2026
I don't really do that unboxing thing, but I'm delighted that this package arrived today. Here it is in the flesh, and I think it looks very handsome. And in time to take to Copenhagen in a couple of weeks!
The Man Who Broke Reality - new book by Philip BallA box of copies of The Man Who Broke Reality.
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Philip Ball @philipcball.bsky.social · 11/09/2026
I wonder if this might be a turning point. I'd like to think so. Because this declaration speaks to so much about the problem with AI in such contexts. If it can be of help in, say, drug discovery, that's fine. But it's precisely because maths doesn't have those stakes that the message is powerful..
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Genetics Society of America @genetics-gsa.bsky.social · 11/09/2026
In this perspective article, @cbo.bsky.social considers the numerous ways in which the study of empirical fitness landscapes impacts diverse fields: theoretical biology, biomedicine, engineering, and others. Read more in #GENETICS about the historical roots of this important idea 🔗 buff.ly/nGsK5Cz
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Genetics Society of America @genetics-gsa.bsky.social · 10/09/2026
To what extent does the fitness seascape alter our picture of evolutionary genetics?  In #G3journal, Swathi Nachiar Manivannan and @cbo.bsky.social address this question using a set of empirical fitness seascapes on how features vary across environments of various kinds. 🔗 buff.ly/4rVh3cP
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estebanmoro @estebanmoro.bsky.social · 04/09/2026
New paper! Are universal models of human behavior really universal? Universal mobility models can work remarkably well on average while systematically failing for some socioeconomic groups. Accurate for whom? academic.oup.com/pnasnexus/ar... Led by Ludovico Napoli with @martonkarsai.bsky.social
The figure is taken from the paper. It shows the maps of different cities in the US with areas (census tracts) colored proportionally to how bad/good the universal model describes the behavior of people in that area. The patterns show that model precision localizes around specific (low-income) areas
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C. Brandon Ogbunu @cbo.bsky.social · 04/09/2026
I'm, like, totally shocked "Mutating every DNA letter of a genome shows surprising effects — and the limits of AI" www.nature.com/articles/d41...
nature.com
Mutating every DNA letter of a genome shows surprising effects — and the limits of AI
Top artificial-intelligence models failed to predict the biological consequences of rewriting a virus's entire DNA code.
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C. Brandon Ogbunu @cbo.bsky.social · 03/09/2026
Now a Featured article in the September issue of #G3 (@genetics-gsa.bsky.social) academic.oup.com/g3journal/ar...
academic.oup.com
Deconstructing empirical fitness seascapes across scales of granularity
This study examines fitness seascapes, maps of how genetic mutations affect an organism's success while accounting for environmental context. Manivannan an
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Quanta Books @quantabooks.org · 01/09/2026
🚨New book announcement! 🚨Evolutionary biologist William C. Ratcliff’s (@wcratcliff.bsky.social) LIFE UNBOUNDED (forthcoming 2029) delivers a sweeping narrative of the emergence of complex life, and how a sterile planet transformed into the rich mosaic of beings on Earth today.
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Santa Fe Institute @sfiscience.bsky.social · 19/08/2026
Influenza spreads faster in a crowded barracks or prison. Ebola proliferates when hospital beds run short. A new paper in Biology Letters, led by SFI's Brandon Ogbunu, introduces "structural causal influence," quantifying how social inequality shapes disease spread and whether interventions work.
santafe.edu
Modeling social inequality in epidemics
For decades, researchers have rigorously documented the way social inequality shapes the spread of disease. In parallel, mathematical models have emerged for forecasting epidemics and weighing differe...
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Santa Fe Institute @sfiscience.bsky.social · 02/04/2025
“Discoveries,” Ogbunu says, “are made when you borrow ideas from certain disciplines and carefully and responsibly combine them.” www.santafe.edu/news-center/...
santafe.edu
SFI welcomes C. Brandon Ogbunu to Resident Faculty
Over the past three years, C. Brandon Ogbunu has become a familiar face at SFI as an External Professor. In February, he joined SFI as a part-time Resident Professor.
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Sean Carroll @seanmcarroll.bsky.social · 29/08/2026
Ever wonder what "information" really means? Here's our new paper, led by @frosas.bsky.social, that lays out the multiple ways the term is used in natural science. rdcu.be/fCDGv
A chart describing four faces of information: Engineering, Statistical, Thermodynamic, and Ontological.
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Tom Near @tjnear.bsky.social · 29/08/2026
1/7 🐟🧬 New preprint! "The largest radiations of freshwater fishes initiated at the K-Pg boundary" Phylogeny of Otocephala: Clupeiformes, Alepeocephaliformes, & Ostariophysi 144 species, UCEs + whole genomes, Bayesian dating. 11,700+ species covered. Here is what we found 🧵👇
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Natalie Bennett @nataliegreenpeer.bsky.social · 27/08/2026
Urgently need to #Unlearn hubris We know so little: Genomes are not 'machine blueprints'; biology is far richer & more complex than acknowledged. "Genetic diversity is shaped not only by inherited factors but also biological processes that vary from person to person" phys.org/news/2026-08...
phys.org
Unexpected source of genetic diversity found in human sperm
Scientists have identified an unexpected source of genetic variation in human sperm that occurs earlier in sperm development than previously thought. Published in Nature, researchers at the Wellcome S...
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C. Brandon Ogbunu @cbo.bsky.social · 26/08/2026
Science is under direct political attack. But we cannot defend it with a naive fantasy of the science that we've inherited. In @bostonreview.bsky.social's “How to Save Science” forum, I argue that “trust us, we’re scientists” is not a proper social contract. www.bostonreview.net/forum/how-to...
bostonreview.net
“Trust Us, We’re Scientists” and Other Clichés
C. Brandon Ogbunu responds to Zeynep Pamuk in our forum, “How to Save Science.”
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Nature @nature.com · 21/08/2026
More than 50 studies on cell aging have apparently used the wrong antibody to identify a key protein in experiments go.nature.com/45FrimI
go.nature.com
Sleuth identifies dozens of studies that used the wrong antibody
The case is the latest example of this scientific workhorse being misused in experiments.
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Reposted by C. Brandon Ogbunu
Nature @nature.com · 20/08/2026
The use of AI to write scientific papers could be much more prevalent than was previously thought go.nature.com/4xeEyea
go.nature.com
Staggering 90% of biomedical papers now show signs of AI help
The figure, which is much higher than previous estimates of Large Language Model use, is for papers published in December and archived in PubMed
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C. Brandon Ogbunu @cbo.bsky.social · 20/08/2026
1/8: 🚨New Paper🚨 "Structural causal influence captures the forces of social inequality in models of infectious disease." Published in 'Biology Letters' (@royalsocietypublishing.org) Coverage here: www.santafe.edu/news-center/... Paper link here: royalsocietypublishing.org/rsbl/article...
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Gen Wojcik @genandgenes.bsky.social · 17/08/2026
I have all the usual points to make about this (eugenicists committing fraud by preying on reproductive anxiety, while also promoting the intended societal consequences as if it were scientifically valid), but at this point all you can hear when I open my mouth is a swarm of angry bees.
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Anna Allen @akallen10.bsky.social · 17/08/2026
New NSF BIO solicitation is live.... this replaces the previous IOS, MCB, DEB solicitation www.nsf.gov/funding/oppo...
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Dan Garisto @dangaristo.bsky.social · 17/08/2026
NSF releases some NOFOs for some directorates. Staff say they've been held up at OSTP for a while.
nsf.gov
August 2026 Notices of Funding Opportunity for Foundational Research
Learn about new NSF funding opportunities prioritizing foundational research across the sciences and engineering.
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Carl Zimmer @carlzimmer.com · 15/08/2026
Grateful for review of Air-Borne by @cbo.bsky.social: "Zimmer combines narrative precision, journalistic range, and scientific synthesis to produce a book that is both informative and intellectually ambitious." www.journals.uchicago.edu/doi/full/10.... & www.penguinrandomhouse.com/books/724793...
penguinrandomhouse.com
Air-Borne by Carl Zimmer: 9780593473597 | PenguinRandomHouse.com: Books
One of Smithsonian Magazine's Ten Best Science Books of 2025 The fascinating, untold story of the air we breathe, the hidden life it contains, and invisible dangers that can turn the world upside dow...
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Philip Ball @philipcball.bsky.social · 10/08/2026
"The central challenge is no longer building models that reproduce biological behavior, but building models from which causal structure can be inferred." Very sensible paper about not just throwing everything into your simulation or model. arxiv.org/abs/2608.06998
arxiv.org
Simulating is not always understanding: When model complexity obscures biology
In cell biology, computational models of biological systems range from minimal representations with a handful of parameters to whole-cell simulations tracking thousands of molecular species across a c...
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Sara Lipton @medievalsara.bsky.social · 08/08/2026
www.geneseo.edu/enrollment-m... “When we keep the conversation focused only on Yale, Harvard, etc., we ignore the millions of students…for whom an excellent, affordable education is already a reality, at [public] institutions.”
geneseo.edu
The College Affordability Crisis is Real, but the Media is Looking at the Wrong Schools
Sturges Hall (Photo by Keith Walters ’11) Opinion By Costas Solomou, Vice President, Enrollment Management Published by the Office of Enrollment Management When Yale University released its Committee ...
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Alex Diaz-Papkovich @alexandr.bsky.social · 05/08/2026
How does human genetics research live in the information ecosystem? Is it misused? Misrepresented? In my paper with @sramach.bsky.social, we tackle this question with 25 years of Wikipedia data, AI chatbot responses, and pages from Grokipedia www.biorxiv.org/content/10.6...
biorxiv.org
From Wikipedia to AI: Measuring 25 years of synthesis of human genetics research in the public-facing information ecosystem
Genetics research frequently intersects with ethnicity, nationality, and race, making it uniquely vulnerable to misrepresentation. Yet, 25 years after the initial sequencing of the human genome, there...
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C. Brandon Ogbunu @cbo.bsky.social · 04/08/2026
🚨NEW PAPER 🚨 "Deconstructing empirical fitness seascapes across scales of granularity" published in #G3 (@genetics-gsa.bsky.social) 1/2 The fitness landscape has been among the most influential instruments in evolutionary theory for nearly a century. But we often treat them as fixed and static.
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Joanna Masel @joannamasel.bsky.social · 04/08/2026
We derive a working hypothesis for how the genetic code evolved, by assuming LUCA-depleted amino acids came early, using codons we infer via the 2-1-3 rule. We validate with independent data and a control ordering ecoevorxiv.org/repository/v... @seekingluca.bsky.social @hanonmcshea.bsky.social 1/13
ecoevorxiv.org
The series of genetic codes that preceded our own
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Matthew Hahn @3rdreviewer.bsky.social · 31/07/2026
Very cool pair of papers demonstrating little link between amount of additive genetic variation and amount of nucleotide variation within species: journals.plos.org/plosbiology/... www.pnas.org/doi/10.1073/...
journals.plos.org
Levels of additive genetic variation vary substantially between species
Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...
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Bryan Gitschlag @bryangitschlag.bsky.social · 08/09/2025
NEW PAPER! Some kinds of genetic mutations are more likely to arise than others. Such "biases" in mutation vary between species. Analyzing data from 14 species, we show that this variation explains species differences in the genetics of adaptation! (1/3) www.biorxiv.org/content/10.1...
Graph showing a positive correlation between "bias in adaptive outcome" on the vertical axis and "mutation bias" on the horizontal axis, with 14 data points representing 14 respective species, with a line of best fit equal to a slope of 0.82 on the log-scale axes. Each data point contains horizontal and vertical error bars to illustrate the uncertainty in both the mutational and adaptive data. The 95% confidence interval of the slope is shown in parentheses (0.44 to 1.24), based on 10,000 simulated data sets, where the simulated data sets are based on statistical resampling of the empirical data (i.e. "bootstrap" data sets). Regression lines based on these bootstrap data sets are shown as light gray lines.

The type of bias reported here refers to the ratio of transitions versus transversions, where transitions are a DNA mutation that preserves the basic structure of the DNA base (i.e. a purine-to-purine or pyrimidine-to-pyrimidine mutation), and transversions are mutations that alter the structure of the DNA base at a particular site (i.e. replacing a purine with a pyrimidine or vice versa). In other words, this graph shows that transitions contribute more toward adaptive evolution in species where transitions arise at a higher rate.
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Joe Brennan @biologyjoe87.bsky.social · 20/07/2026
Out now in PLOS Computational Biology!
journals.plos.org
Eight quick tips for data-model integration in ecology
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Wayne Maddison @waynemaddison.bsky.social · 18/07/2026
An important and beautiful paper on the central role of natural history in ecology and evolutionary biology.
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the beggars out of here getter @milesklee.bsky.social · 13/07/2026
My privilege to share some lovely stories from the science community about what Sam Neill's timeless performance as Dr. Alan Grant in Jurassic Park meant to them—and why it will continue to inspire kids to chase their own discoveries for years to come.
wired.com
Sam Neill Inspired a Generation of Scientists
The actor, who died at age 78 on Monday, embodied a passionate approach to research and positive masculinity in his role as paleontologist Alan Grant in the 1993 blockbuster Jurassic Park.
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Adam Rutherford @adamrutherford.bsky.social · 11/07/2026
My review of Evolution. The BBC series, not the concept. But to be fair, I'm a big fan of both. @chrisgpackham.bsky.social www.ft.com/content/c6c0...
ft.com
Why new BBC series Evolution is a giant leap forward for science on TV
Adam Rutherford salutes a show that finally links the spectacle of natural history with the science that explains it
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Ken Appleby @kenappleby.bsky.social · 10/07/2026
I recently discovered this by @philipcball.bsky.social on my bookshelves and re-read it. It's 20 years old now, but a fascinating, deep, comprehensive account of the connections between physical and social sciences. The 3-page epilogue is a gem. #goodreads
Paperback book cover: "Critical Mass" by Phillip Ball. 2006
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Evolution Letters @evolletters.bsky.social · 10/07/2026
Can species always evolve fast enough to keep up with environmental change? A resurrection experiment in morning glory shows genetic constraints can limit adaptation—even under strong selection. doi.org/10.1093/evle... @gbaucom.bsky.social @johnstinchcombe.bsky.social Image credit:Cbaile19 Wikimedia
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Kevin Mitchell @wiringthebrain.bsky.social · 10/07/2026
Excellent overview by @philipcball.bsky.social on why the concept of "agency" is both central to biology and hotly contested www.quantamagazine.org/is-life-just...
quantamagazine.org
Is Life Just Different? | Quanta Magazine
The idea of ‘biological agency’ — that life devises its own goals and behaves accordingly — complicates our understanding of what it means to be alive. But does it serve a scientific purpose?
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Julien Lie-Panis @jliep.bsky.social · 09/07/2026
Why do societies rely on rigid moral rules? Don't lie. Keep your promises. Don't steal. We all recognize there are good reasons to make exceptions. So why are moral rules so often categorical? Our new paper proposes an answer. 🧵
Screenshot of article title page, "Why human societies adopt rigid moral rules"
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Harmit Singh Malik @harmitmalik.bsky.social · 09/07/2026
Coming late to this story: Suspecting AI cheating, Ivy League prof ordered an in-person final; scores fell 50% arstechnica.com/ai/2026/07/w...
arstechnica.com
Suspecting AI cheating, Ivy League prof ordered an in-person final; scores fell 50%
AI cheating leads to "a failed society," professor says.
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Yuki Haba @yukihaba.bsky.social · 06/07/2026
Rapid urban evolution of the dengue mosquito in West African cities Shift in genome and behavior of the mosquitoes towards greater specialization on humans, over just five years. Such cool work, congrats Noah Rose et al! www.biorxiv.org/content/10.6...
biorxiv.org
Rapid urban evolution of the dengue mosquito in West African cities
Aedes aegypti is an exceptionally effective global vector of human disease because of its strong specialization on human hosts and habitats. However, in its native range in Africa, many populations ne...
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Ricard Solé @ricardsole.bsky.social · 04/07/2026
How can an extremely simple equation open the door to virtually infinite complexity? Fifty years ago, Bob May’s classic paper in @nature.com on chaos showed how deterministic rules can generate unpredictability, with deep implications for ecology, physics & beyond. mym.iimas.unam.mx/ramon/docs/M...
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Ricard Solé @ricardsole.bsky.social · 03/07/2026
The first copy of my new @princetonupress.bsky.social book has just arrived at the office. It explores death in all its forms, from cells to minds, machines, languages and information. A complexity/evolutionary perspective, from Frankenstein to neuroscience. Soon out: www.amazon.com/Endless-Endi...
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C. Brandon Ogbunu @cbo.bsky.social · 02/07/2026
New for @undark.org: Mathematicians have signed the Leiden Declaration for AI. I argue that the life sciences needs one: built for noisy, context-dependent systems, w/ disclosure, human accountability, wet-lab validation, & rules that evolve as fast as the tools do. undark.org/2026/07/02/o...
undark.org
Biologists Should Articulate Their Position on AI
Opinion | In the Leiden Declaration, mathematicians issued a treatise on how AI challenges their field. Others must do the same.
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