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Roshni Patel

@roshnipatel.bsky.social
594 followers 639 following 73 posts

assistant prof at University of Oregon. interested in pop gen, stat gen, human complex traits. also ELSI, metascience, ethics education, etc. she/they. 🌈 roshnipatel.github.io

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Reposted by Roshni Patel
Maitreya Dunham @maitreya.bsky.social · 24/09/2026
Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.
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Stand Up for Science! @standupforscience.net · 18/09/2026
We scraped through the data and found that 50% of all clinical trials are at risk of being cancelled. 1,026 cancer trials 273 pediatric trials 115 heart disease trials 184 diabetes trials This is unacceptable and inhumane.
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Dmitri Petrov @petrovadmitri.bsky.social · 17/09/2026
We are searching for an Assistant Professor in Evolutionary Biology! Looking for colleagues asking fundamental questions relating to evolutionary processes and drivers of evolutionary patterns. If you think it is you, please do apply! And please repost. facultypositions.stanford.edu/jobs/assista...
facultypositions.stanford.edu
Assistant Professor in Evolutionary Biology - Stanford University, California, United States
The Department of Biology at Stanford University seeks applicants for a tenure-track Assistant Professor in Evolutionary Biology. A successful candidate will conduct research that asks fundamental que...
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Kevin Bird @stairwaytokevin.bsky.social · 15/09/2026
Very cool paper and, although still not as cool as plants, a very exciting time to study human genetics and evolution!
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Ana Ignatieva @anaignatieva.bsky.social · 14/09/2026
We are advertising a 3 year postdoc position for a project on ARGs and structural variation! Based at Oxford stats. Closing date noon 12 October, full details here: my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
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Yun Deng @yundeng.bsky.social · 14/09/2026
I am excited to share that I will be joining the Baker Institute for Animal Health and College of Veterinary Medicine at Cornell University as an Assistant Professor next spring! I am grateful to my mentors and colleagues who have supported me throughout this journey.
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Roshni Patel @roshnipatel.bsky.social · 14/09/2026
These are of course very old questions with tremendous recent progress; we focus mostly on the recent progress and what it offers for the next era of studying human genetics in biobanks. Excited this preprint is out and we'd of course love to hear any thoughts!
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Jeff Spence @jeffspence.github.io · 14/09/2026
@roshnipatel.bsky.social and I wrote about using biobanks to learn about evolution, and how those findings shape interpretations of association studies. We focused on estimating evolutionary constraint and relating relating selection on variants to selection on traits and include open questions.
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Peter Ellis @pjie2.bsky.social · 12/07/2026
Let biological sex be multifaceted, as all biology is. And when you need to be precise in scientific research, be precise. Say ‘gametic sex’ or ‘chromosomal sex’ or ‘anatomical sex’, or whatever is appropriate to your own work.
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Christa Caggiano @christacaggiano.bsky.social · 09/07/2026
Working on this project was so fun! ❤️ It's really awesome to work with so many passionate scientists who are all committed to improving our field (despite a climate that might not always be so friendly to that) We'd love any feedback, especially from other trainees and early career researchers!
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Roshni Patel @roshnipatel.bsky.social · 07/07/2026
I think this work really underscores that we are at a turning point in human genetics. There is a growing consensus that doing good research in human genetics requires an expanded skillset (including, e.g., one that can navigate the relationship between genetics, ancestry, and pop descriptors) (1/)
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Roshni Patel @roshnipatel.bsky.social · 07/07/2026
So excited to see this out! It was an absolute joy and honor to work so closely w @jayatirsharma.bsky.social and @christacaggiano.bsky.social on this - both are terrific examples of the kind of interdisciplinary human genetics researchers that we need more of (and will be on the job market soon 👀)
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Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026
In what has been a labor of love & joyful collaboration, we are super excited to share our preprint on recommendations towards the ethical and accurate use of population descriptors generated from a survey by trainees, for trainees. www.biorxiv.org/content/10.6...
biorxiv.org
Recommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchers
Despite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ...
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Candy Corn of defiance @drlatigo.bsky.social · 30/06/2026
I commented yesterday, there’s still time
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Tami Gjorgjieva @tamigj.bsky.social · 18/05/2026
Hi Genetics/Comp-Bio community 👋 Interested in mentoring a comp-bio research student in East Africa over the summer? Do you have any experience in bioinformatics, biostats, genome/RNA-seq analyses, ML, or metagenomics? We'd love to have you as a mentor in our new program! 🧵 (1/n)
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Kevin Bird @stairwaytokevin.bsky.social · 10/05/2026
People have got to wake up to how bad the situation in US science is right now
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Max Kozlov @maxkozlov.bsky.social · 06/05/2026
When the NIH abruptly terminated thousands of research grants last year, the fallout wasn’t distributed equitably. A new analysis suggests the cuts disproportionately hit women, BIPOC, and LGBTQ+ investigators. My latest for @nature.com
nature.com
NIH grant cuts disproportionately hit minority and female scientists
A survey reveals sharp divides in who bore the brunt of last year’s spree of grant cancellations by the Trump administration.
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Krystal Tsosie @kstsosie.bsky.social · 17/04/2026
DNA is not the same as kinship. Our perspective paper argues that treating genetics as the ultimate proof of identity or family can: • erase community-defined relationships • reinforce Western biases • and even cause real harm in policy + research Special Issue: www.cambridge.org/core/journal...
Screenshot of a PDF of the published article. Title: "The tie that binds us? Challenging the primacy of DNA in kinship studies and re-centring community in defining human connections across time"
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Shoumita Dasgupta, PhD @profdasgupta.bsky.social · 18/03/2026
🧪 Pathways for future scientists are becoming scarce, threatening a strong and innovative workforce: “We are not simply shrinking budgets. We are shrinking who gets to imagine themselves in science at all.” @jpflores.rbind.io hechingerreport.org/opinion-path...
hechingerreport.org
OPINION: We need to expand research experience for college students to HBCUs, regional public universities and community colleges
If we want a scientific workforce capable of addressing the challenges we face, we must invest in scientists long before they become scientists. That means expanding research opportunities, supporting...
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Jenna Norton @jenna-m-norton.bsky.social · 06/03/2026
Current NIH leadership want you to think they are using rigorous, consistent & scientific processes to screen studies to align them with agency priorities. But the process that they have put down on paper is a sham. It’s important to know NIH is not following its own guidance. Here’s why: 🧵1/
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Jenna Norton @jenna-m-norton.bsky.social · 06/03/2026
7/ In reality, my colleagues still inside NIH tell me that their assessments are largely ignored. Once a grant or application is picked up by the tool, they are almost never able to move the grant forward as is - regardless of the scientific justification.
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Shai Carmi @shaicarmi.bsky.social · 01/03/2026
Great perspective by @philipcball.bsky.social. Elementary genetics teaching (HS/college) focuses on Mendelian traits (single gene => single trait). However, it is now clear that polygenicity and pleiotropy are the norm. Curriculum must change accordingly. www.sciencedirect.com/science/arti...
sciencedirect.com
Should biology put complexity first?
The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing dama…
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Jazlyn Mooney @jazlynmooney.bsky.social · 26/02/2026
Excited that our work was featured on the local (Bay Area) news for their Black History month series. Interview with Noah and clips from my interview with @dornsife.usc.edu and CGSI talk in the article below www.nbcbayarea.com/discover-bla...
nbcbayarea.com
Stanford researchers help trace ancestry for African Americans
A group of Stanford researchers is offering a mathematical model to help link family connections up to 410 years ago.
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Princeton University Press @princetonupress.bsky.social · 26/02/2026
Sam Trejo and @daphmarts.bsky.social, authors of What We Inherit: How New Technologies and Old Myths Are Shaping Our Genomic Future, write for @livescience.com about new reproductive technologies and the importance of regulation:
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Rebecca Sear @rebeccasear.bsky.social · 17/02/2026
Publications which use "national IQ" data still appearing in Springer Nature journals in 2026. Cool cool doi.org/10.1057/s415...
doi.org
Beyond GDP: national intelligence quotient as a catalyst for sustainable socioeconomic welfare - Humanities and Social Sciences Communications
Humanities and Social Sciences Communications - Beyond GDP: national intelligence quotient as a catalyst for sustainable socioeconomic welfare
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Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 09/02/2026
Fun news! @gcbias.bsky.social and I are teaching a 2-week online population genetics workshop this summer to raise money for the Center for Population Biology at UC Davis. We're trying to gauge interest -- please fill this out if you might be interested! And please share broadly!
docs.google.com
Davis Summer Population Genomics Program
Want to learn population genetics? Please fill out this form to indicate your potential interest in a 2-week intensive online summer population genetics course taught by Jeffrey Ross-Ibarra and Graham...
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Colette Delawalla, PhD @cdelawalla.bsky.social · 30/01/2026
Someone on LinkedIn just asked me "why scientists should care and mobilize" right now. But the answer is simple: BECAUSE IT IS THE MORALLY RIGHT THING TO DO. People are being killed in the street, our democracy is being eroded, & we are watching the onset of authoritarianism before our eyes. 1/
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Jenna Norton @jenna-m-norton.bsky.social · 29/01/2026
To the extent that the fate of NIH and ICE funding may continue to be linked, we as scientists may feel forced to choose between protecting our own funding and the safety and wellbeing of our neighbors. This is a false choice. open.substack.com/pub/sciencea...
open.substack.com
Demanding a Homeland Security bill that reins in lawlessness is the best path for science–even if it stalls NIH funding
The Senate voted today on a final funding package that included both the National Institutes of Health (NIH) and Immigration and Customs Enforcement (ICE), among many other agencies and institutions.
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Joyce Wang @joyce-yiyi-wang.bsky.social · 26/01/2026
Relatedly, some cool recent work from @roshnipatel.bsky.social, Jeffrey Spence, @jkpritch.bsky.social et al. dives deep into expectations, based on models of natural selection, for allele frequency in a group B conditional on allele frequency in group A. academic.oup.com/genetics/art... (16/27)
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Joyce Wang @joyce-yiyi-wang.bsky.social · 26/01/2026
Our work on the generalizability of polygenic scores (PGS) from the @arbelharpak.bsky.social Lab is now officially out! We examine the accuracy of PGS predictions at the individual level. We make 3 observations that expose gaps in our understanding of PGS “portability.” rdcu.be/e0LAr (1/27)
rdcu.be
Three open questions in polygenic score portability
Nature Communications - Genetic predictors of health outcomes often drop in accuracy when applied to people dissimilar to participants of large genetic studies. Here, the authors investigate the...
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Max Kozlov @maxkozlov.bsky.social · 22/01/2026
🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year. That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027. A wonky bureaucratic problem with big implications. A short 🧵
nature.com
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
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Nikhil Milind @nikhilmilind.dev · 06/01/2026
How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS. In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time! doi.org/10.64898/202... 1/n
doi.org
High false sign rates in transcriptome-wide association studies
Transcriptome-wide association studies (TWAS) are widely used to identify genes involved in complex traits and to infer the direction of gene effects on traits. However, despite their popularity, it r...
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Sasha Gusev @sashagusevposts.bsky.social · 13/12/2025
I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.
open.substack.com
Embryo selection company Herasight goes all in on eugenics
...
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Mineto Ota @minetoota.bsky.social · 11/12/2025
Thank you Alex! Excited to see our paper published in @nature.com ! Huge thanks to @jeffspence.github.io , @tkyzeng.bsky.social , @emmamarydann.bsky.social, @nikhilmilind.dev, @marsonlab.bsky.social, @jkpritch.bsky.social, and all the members of the Pritchard and Marson labs for your enormous help!
rdcu.be
Causal modelling of gene effects from regulators to programs to traits
Nature - Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
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Mineto Ota @minetoota.bsky.social · 11/12/2025
After time in the Bay Area, I’ve started a new role as Lecturer in the Department of Allergy and Rheumatology at the University of Tokyo. We’re the group of clinicians who see patients with autoimmune diseases, while researching new treatments and patient stratification. (continued)
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Rebecca Sear @rebeccasear.bsky.social · 09/12/2025
“What I do think is that it has become normalized in modern behavioral genomics to do what you have to do in order to make every result, no matter how small, look like a win for team genetics” ericturkheimer.substack.com/p/within-fam...
ericturkheimer.substack.com
Within family prediction of psychopathology
Honey it's fine. The ratio with my shoe size is actually pretty good.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 08/12/2025
I taught Genetics again this year. We need to include discussion of the problematic history of our field, especially as the claims of eugenics are once again centered in our political discourse. Last year I wrote this piece, explaining my reasoning and approach 🧪 1/n www.cell.com/trends/genet...
Trends in
Genetics
Science & Society
We must not ignore
eugenics in our genetics
curriculum
Mark Peifer1,2,*
Eugenics, that promoted planned
breeding to ensure 'racial improve-
ment', was central to the develop-
ment of genetics and led to
horrifying policies. However, eugen-
ics is not dead and continues to
influence science and policy today.
Thus, we should include eugenics
in our undergraduate classes to
remind students that scientists
must speak out when others lie
about science and use it to further
their political views.
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Alexander Robertson @alexrob.bsky.social · 08/12/2025
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
nature.com
Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution
A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...
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Siobhán Cully 🇺🇸 🐱🥼🤓🩼 @siobhancully.bsky.social · 04/12/2025
And this. My experience also supports that being *more* open about racist, sexist, and ableist histories of our fields is more engaging, not less, for students (and faculty) from minoritized backgrounds. Transparency can only enhance rigor.
Text from article advocating for transparent recognition of racist past in our disciplines to encourage, not discourage, more diverse engagement.
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Scott Gottlieb, MD @scottgottliebmd.bsky.social · 03/12/2025
12 former commissioners of the FDA came together to write a Perspectives piece for the New England Journal of Medicine; raising our concerns about recent changes to vaccine approval policy at the FDA and its implications for patients and public health.
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Doc Edge @docedge.bsky.social · 02/12/2025
It was a total pleasure to work with @roshnipatel.bsky.social on this, who really led the charge in all respects. Anyone interested in learning about the intersection of population genetics and statistical genetics should check out her new lab in Oregon!
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Roshni Patel @roshnipatel.bsky.social · 01/12/2025
As promised, a longer thread on what I consider to be some of the most interesting and important contributions of this paper (1/10)
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Joshua G. Schraiber @jgschraiber.bsky.social · 01/12/2025
This was a super fun project to do my small part on. @roshnipatel.bsky.social really helped me understand what we're doing when we're trying to "control for genetics" when assessing associations between interventions and outcomes, and how a lot of the standard ways to do so are simply inadequate.
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Roshni Patel @roshnipatel.bsky.social · 01/12/2025
Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)
biorxiv.org
Observational epidemiological studies can mitigate genetic confounding with the genetic relatedness matrix
Observational studies are commonly used in psychology and epidemiology to identify risk factors correlated with health outcomes. However, these studies are vulnerable to confounding when shared geneti...
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Hanbin Lee @epigenci.bsky.social · 30/11/2025
www.biorxiv.org/content/10.1... We finally submitted the earlier preprint to a journal after massive restructuring. We've expanded the REML section for those interested in the method. We clarify that ARG-LMM estimates mutational variance and not additive variance.
biorxiv.org
Genetic prediction with ARG-powered linear algebra
Ancestral recombination graphs (ARGs) are an attractive means for quantitative genetic analysis of complex traits because they encode the realized genetic relatedness between a sample of individuals i...
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Alan Rogers @alanrogers.bsky.social · 27/11/2025
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
github.com
GitHub - alanrogers/popgen: A course on population genetics
A course on population genetics. Contribute to alanrogers/popgen development by creating an account on GitHub.
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Sarah Nelson @blueyedgenes.bsky.social · 25/11/2025
Out now in @natgenet.nature.com, our Comment analyzing uses of the Human Genome Diversity Project (HGDP), a controversial dataset in human genomics research. A 🧵 rdcu.be/eRu65 1/
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Lino Ferreira @linoafferreira.bsky.social · 24/11/2025
Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank! A thread... 🧵 www.medrxiv.org/content/10.1...
medrxiv.org
Interactions with polygenic background impact quantitative traits in the UK Biobank
Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...
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Genetics Society of America @genetics-gsa.bsky.social · 19/11/2025
In #GENETICS, @alan-aw.bsky.social et al. introduce models for how individual variant effects in admixed individuals may be influenced by ancestry, contributing to work on the genetic architecture of complex traits and their implications for polygenic prediction. buff.ly/34ZvEil
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Jeremy Yoder says no war @jbyoder.org · 19/11/2025
this is cool, and more departments should do it!
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