Reposted by Drummond LabVaughn Cooper @vscooper.micropopbio.org · 25/09/2026FYI to everyone submitting this October NIH cycle You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted. Great timing! 78592
Reposted by Drummond LabRasmus Jensen @rasmusjensen.bsky.social · 25/09/2026🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET 1023194
Reposted by Drummond LabMaitreya Dunham @maitreya.bsky.social · 24/09/2026Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly. 110498
Reposted by Drummond LabRan Blekhman @blekhman.bsky.social · 23/09/2026We have to stop using "paper count" as a useful scientific metric. More writing output no longer means more knowledge gained www.washingtonpost.com/education/20...washingtonpost.comOne professor’s AI-assisted output: 200 papers and 14 books this yearAn online platform removed 257 papers written or co-written by the University of Chicago’s Nicholas Polson after other academics raised questions. 1011147
Reposted by Drummond LabDmitri Petrov @petrovadmitri.bsky.social · 17/09/2026We are searching for an Assistant Professor in Evolutionary Biology! Looking for colleagues asking fundamental questions relating to evolutionary processes and drivers of evolutionary patterns. If you think it is you, please do apply! And please repost. facultypositions.stanford.edu/jobs/assista...facultypositions.stanford.eduAssistant Professor in Evolutionary Biology - Stanford University, California, United StatesThe Department of Biology at Stanford University seeks applicants for a tenure-track Assistant Professor in Evolutionary Biology. A successful candidate will conduct research that asks fundamental que... 5151189
Reposted by Drummond LabMatt Barber @biobarber.bsky.social · 17/09/2026My lab is 10 years old today! I have so many thoughts and feels... 1431
Reposted by Drummond LabGraham Coop @gcbias.bsky.social · 10/09/2026I’m looking to hire an NIH funded postdoc to join our lab here at Davis (please RT). Ongoing areas of interest include: 1) polygenic signals of selection from time series, ARGs, GWAS, etc 2) The interpretation of GWAS, polygenic scores, & sources of confounding 2119183
Reposted by Drummond LabHarmit Singh Malik @harmitmalik.bsky.social · 10/09/2026Reposting this ongoing search (any discipline of biology) for an Assistant to Associate level colleague in the Division of Basic Sciences at Fred Hutch. Great city, great colleagues, great core facilities, great trainees. 16468
Reposted by Drummond LabJanet Iwasa @jiwasa.bsky.social · 09/09/2026Interested in molecular animation? Give ProteinBlender a try! It's free and open source. animation-lab.github.io/ProteinBlend... The latest tools include a DNA builder (shown in the tutorial video below). We'd love to hear what you think! We have short tutorials that cover all the features! 19542
Drummond Lab @drummondlab.bsky.social · 08/09/2026We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Join us! apply.interfolio.com/191981 bcmb.uchicago.edu 190106
Reposted by Drummond LabPhilip Ball @philipcball.bsky.social · 26/08/2026Apologies in advance to all Danish speakers for my pronunciation in the audiobook of this. www.hachette.co.uk/titles/phili...hachette.co.ukThe Man Who Broke Reality'A true tour de force. A fresh, authoritative, meticulously researched and utterly engaging examination of arguably the deepest thinker of the twentieth cent... 1122
Reposted by Drummond LabJeff Lewis @lewislab.bsky.social · 30/07/2026So many emotions right now. I had almost given up hope that this one would get funded. Feeling relief, excitement to do the science, gratitude to everyone on the inside trying to hold NIH together, survivor's guilt. All the things. 171289
Reposted by Drummond LabShahar Sukenik @shaharsu.bsky.social · 29/07/2026Finally out - our work on high throughput design and characterization of disordered protein sequences 🪱🪱🪱. A long time collaboration with BFFs @alexholehouse.bsky.social and @remenecker.bsky.social, with experimental work led by @trevorbrandt.bsky.social and @karaehunt.bsky.social.nature.comRational design of disordered proteins for sequence–function investigation - NatureGOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships. 2178
Reposted by Drummond LabD. Allan Drummond @dadrummond.art · 29/07/2026Got the news today that I've been promoted to Full Professor of Biochemistry & Molecular Biology at The University of Chicago. A tremendous honor, one made possible by an incredible group of trainees who I've had the pleasure of working with over the past twenty years. Best is yet to come! 🤓🔬 4642523
Reposted by Drummond LabRedPen/BlackPen @redpenblackpen.bsky.social · 13/04/2026thinking a lot about this cartoon this week... WHY DID I AGREE TO THOSE REVIEWS?? 0205
Reposted by Drummond LabClaus Wilke @clauswilke.com · 11/03/2026New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/ www.biorxiv.org/content/10.6...biorxiv.org 617972
Reposted by Drummond LabAlex Holehouse @alexholehouse.bsky.social · 12/02/2026Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.nature.comSequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell BiologyLangstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc... 713958
Reposted by Drummond LabAlex Holehouse @alexholehouse.bsky.social · 19/02/2026Papers are like buses... You wait for ages, then two come along at once. Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published! www.nature.com/articles/s41...nature.comAccurate predictions of disordered protein ensembles with STARLING - NatureThe deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input. 69036
Reposted by Drummond LabJerelle Joseph @jerelleaj.bsky.social · 13/02/2026Pablo’s work on “condensate Deborah numbers” is now out in #JCP!! Selected as Editor’s Pick and featured as a #Scilight pubs.aip.org/aip/jcp/arti...pubs.aip.orgMolecular origins of viscoelasticity in biomolecular condensatesBiomolecular condensates are membraneless organelles that compartmentalize functions in living cells. Formed by the phase separation of biomolecules, condensate 0116
Reposted by Drummond LabEduardo Tassoni Tsuchida @eduardotassoni.bsky.social · 12/02/2026I am excited to share the main piece of work from my PhD! In this paper, we investigated the propensities of distinct transcripts in associating with biomolecular condensates, mainly focusing on how heat-induced mRNAs escape condensation and are properly translated. www.biorxiv.org/content/10.6...biorxiv.org 1163
Reposted by Drummond LabFlorent Waltz @florentwaltz.bsky.social · 10/02/2026Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵 416356
Reposted by Drummond LabSoragni:Lab @alice.soragnilab.com · 10/02/2026Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n news.cuanschutz.edu/dbmi/cu-ansc...news.cuanschutz.eduCU Anschutz Recruits National Leader to Launch Functional Personalized Medicine InitiativeCU Anschutz welcomes Alice Soragni to launch a Functional Personalized Medicine Initiative using rapid tumor organoid testing to guide treatment decisions. 4119330
Reposted by Drummond LabJerelle Joseph @jerelleaj.bsky.social · 11/01/2026Out on the #bioRxiv in collaboration with @luciastrader.bsky.social, we probe the molecular basis for thermoresponsive condensation in plants! Work led by Sunita Pathak and @ananyac2000.bsky.social 🥳🥳 www.biorxiv.org/content/10.6...biorxiv.org 0113
Reposted by Drummond LabJerelle Joseph @jerelleaj.bsky.social · 14/01/2026How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social 03614
Reposted by Drummond LabTitus Brown @titus.idyll.org · 28/01/2026How titus organizes computational projects: a (very) short presentation. Comments welcome ;)hackmd.ioHow titus organizes things - HackMDtags: bcb298 071
Reposted by Drummond LabRobert McNees @mcnees.bsky.social · 04/01/2025Physicist and mathematician Isaac Newton was born #OTD in 1643. Newton revolutionized our understanding of mathematics, mechanics, gravity, and optics. Later in life he served as warden of the Royal Mint, reforming currency and foiling counterfeiters. 🧪 🔭 ⚛️ 🪙 Portrait: B. Bramley, after G. Kneller 921140
Reposted by Drummond LabPeter Stockwell @stockwell.bsky.social · 19/12/2025Physicist Leo Szilard, in a short science fiction story from 1948, describing how to retard science by making the funding application longer and harder than the proposed research - now called the ‘Szilard point’ 26830
Reposted by Drummond LabOli Clarke @olibclarke.bsky.social · 18/12/2025very unusual - a tRNA regulated anion channel 25723
Reposted by Drummond LabPrakash Lab at Stanford @prakashlab.bsky.social · 19/12/2025(1/n) What if you never had to make your bed? What if your laundry could fold itself? Folding is everywhere around us - but did you know that folding flat sheets are at the ❤️ of diversity of shapes in the animal world - since 500 million years ago. Our latest work: www.youtube.com/watch?v=nudC...youtube.comSelf-folding laundryYouTube video by PrakashLab 35616
Reposted by Drummond LabYoav Gilad @ygilad.bsky.social · 19/12/2025Faculty position at the department of medicine, University of Chicago. Please share. 0811
Reposted by Drummond LabLukasz Bugaj @bugajlab.bsky.social · 17/12/2025🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇 12010
Reposted by Drummond LabLukasz Bugaj @bugajlab.bsky.social · 16/12/2025🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇 21918
Reposted by Drummond LabYamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n 29546230
Reposted by Drummond LabMatthew Hahn @3rdreviewer.bsky.social · 17/12/2025Have you ever wondered: just how strong *is* the evidence for Muller's ratchet on mtDNA? Well, wonder no more! (Project led by Yu Mo, with @smishra677.bsky.social and @yadirapga.bsky.social) "No molecular evidence for Muller's ratchet in mitochondrial genomes" www.biorxiv.org/content/10.6...biorxiv.orgNo molecular evidence for Muller's ratchet in mitochondrial genomesMuller's ratchet predicts that non-recombining genomes can accumulate deleterious mutations, though molecular evidence for it is rare. Previous studies have tried to detect ratchet-like behavior in mi... 39236
Reposted by Drummond LabClaus Wilke @clauswilke.com · 11/12/2025Become a colleague in my department! Applications close in four days, December 15. 043
Reposted by Drummond LabRobert McNees @mcnees.bsky.social · 04/12/2024"I, at any rate, am convinced that He is not playing at dice." Einstein sent a letter to Max Born #OTD in 1926, in which he gave his oft-quoted objection to the probabilistic interpretation of the wavefunction in quantum mechanics. 🧪 ⚛️ You may be surprised by where this is headed. (1/n)pubs.aip.org 513049
Reposted by Drummond LabMaitreya Dunham @maitreya.bsky.social · 25/11/2025New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...biorxiv.orgThe discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populationsMost mutations are neutral or deleterious, and mutator alleles that increase the mutation rate of an organism are considered rare and short-lived. Here, we report a genomic signature consistent with t... 11710
Reposted by Drummond LabZwicker Group @zwickergroup.bsky.social · 21/11/2025Our review on the physics of phase separation in cells has been published by Rep. Prog. Phys. 🎉 doi.org/10.1088/1361... We hope that the text and citations are helpful for anyone interested in physical descriptions of condensates in cells!doi.orgPhysics of droplet regulation in biological cells - IOPsciencePhysics of droplet regulation in biological cells, Zwicker, David, Paulin, Oliver W, ter Burg, Cathelijne 0184
Reposted by Drummond LabMichael Baym @baym.lol · 20/11/2025Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...science.orgIntracellular competition shapes plasmid population dynamicsFrom populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g... 11437199
Reposted by Drummond LabJosh Riback @superscijew.bsky.social · 04/11/2025(2/10) We found that disparate drivers of acute myeloid leukemia (AML) – including NPM1c, KMT2A-r, and nucleoporin oncofusions – form nuclear condensates with a shared set of proteins including XPO1 and MENIN to drive leukemic gene expression (e.g. HOXA). www.cell.com/cell/fulltex...cell.comDisparate leukemia mutations converge on nuclear phase-separated condensatesMutant NPM1 and various leukemia oncofusions form biophysically indistingishable nuclear condensates, termed C-bodies, which orchestrate leukemogenic gene expression. These findings consolidate divers... 171
Reposted by Drummond LabJosh Riback @superscijew.bsky.social · 04/11/2025(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies. 75323
Reposted by Drummond LabClaus Wilke @clauswilke.com · 13/11/2025My department at UT Austin is looking to hire an Assistant Professor in Evolutionary Biology, broadly defined. Feel free to reach out to me with any questions you may have. apply.interfolio.com/177547apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 14771
Drummond Lab @drummondlab.bsky.social · 11/11/2025Happy that our paper just got accepted. Also happy that it's been available as a preprint for more than 1.5 years on @biorxivpreprint.bsky.social, updated 3x with new experiments, with >7,500 full-text downloads and 20 citations. Before publication. www.biorxiv.org/content/10.1... 141
Reposted by Drummond LabBrett Baker @archaeal.bsky.social · 10/11/2025A wonderful collaboration between my lab and Andy Ellington and Edward Marcotte here at UT. We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)academic.oup.comPlastic degradation by enzymes from uncultured deep sea microorganismsAbstract. Polyethylene terephthalate (PET)-hydrolyzing enzymes (PETases) are a recently discovered enzyme class capable of plastic degradation. PETases are 04120
Reposted by Drummond LabOded Rechavi @odedrechavi.bsky.social · 06/11/2025Please read the thoughtful Blog that @richardsever.bsky.social and the @openrxiv.bsky.social team wrote on integrating pre-prints with AI review openrxiv.org/enabling-rev...openrxiv.orgEnabling options for review: from training and transparency to author-centered AI tools - openRxivPeer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists... 12512
Reposted by Drummond LabRichard Sever @richardsever.bsky.social · 06/11/2025Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...openrxiv.orgEnabling options for review: from training and transparency to author-centered AI tools - openRxivPeer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists... 911664
Reposted by Drummond LabDrug Monkey @drugmonkey.bsky.social · 03/11/2025Slightly less snarkily, manuscript review culture varies a lot. If a person trained in GlamHoundery reviews for a real journal they often are slightly out of step in their demands. So an important editorial function is to enforce the culture of their journal. By saying “nah don’t do all that”. 121
Drummond Lab @drummondlab.bsky.social · 28/10/2025As an author, I frequently encounter reviewers who should be overruled -- gatekeepers. My main complaint is has been that many editors do not have the confidence/expertise to do so (but some do). a) Thank goodness for preprints, b) I review with the expectation that the paper will be published. 4244
Reposted by Drummond LabThe Economist @economist.com · 25/10/2025“It’s too easy to be swamped by a short-term political and social environment.” Neil Shubin tells “Babbage” why he remains optimistic about science in Americaecon.stNeil Shubin: defender of American scienceOur podcast on science and technology. We speak to the polar palaeontologist poised to lead America’s National Academy of Sciences 1167