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Drummond Lab

@drummondlab.bsky.social
228 followers 106 following 44 posts

The Drummond Lab at UChicago (drummondlab.org). Cell stress, biomolecular condensation of proteins and RNA, chaperones, translation, evolution.

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Vaughn Cooper @vscooper.micropopbio.org · 25/09/2026
FYI to everyone submitting this October NIH cycle You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted. Great timing!
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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Maitreya Dunham @maitreya.bsky.social · 24/09/2026
Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.
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Ran Blekhman @blekhman.bsky.social · 23/09/2026
We have to stop using "paper count" as a useful scientific metric. More writing output no longer means more knowledge gained www.washingtonpost.com/education/20...
washingtonpost.com
One professor’s AI-assisted output: 200 papers and 14 books this year
An online platform removed 257 papers written or co-written by the University of Chicago’s Nicholas Polson after other academics raised questions.
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Dmitri Petrov @petrovadmitri.bsky.social · 17/09/2026
We are searching for an Assistant Professor in Evolutionary Biology! Looking for colleagues asking fundamental questions relating to evolutionary processes and drivers of evolutionary patterns. If you think it is you, please do apply! And please repost. facultypositions.stanford.edu/jobs/assista...
facultypositions.stanford.edu
Assistant Professor in Evolutionary Biology - Stanford University, California, United States
The Department of Biology at Stanford University seeks applicants for a tenure-track Assistant Professor in Evolutionary Biology. A successful candidate will conduct research that asks fundamental que...
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Matt Barber @biobarber.bsky.social · 17/09/2026
My lab is 10 years old today! I have so many thoughts and feels...
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Graham Coop @gcbias.bsky.social · 10/09/2026
I’m looking to hire an NIH funded postdoc to join our lab here at Davis (please RT). Ongoing areas of interest include: 1) polygenic signals of selection from time series, ARGs, GWAS, etc 2) The interpretation of GWAS, polygenic scores, & sources of confounding
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Harmit Singh Malik @harmitmalik.bsky.social · 10/09/2026
Reposting this ongoing search (any discipline of biology) for an Assistant to Associate level colleague in the Division of Basic Sciences at Fred Hutch. Great city, great colleagues, great core facilities, great trainees.
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Janet Iwasa @jiwasa.bsky.social · 09/09/2026
Interested in molecular animation? Give ProteinBlender a try! It's free and open source. animation-lab.github.io/ProteinBlend... The latest tools include a DNA builder (shown in the tutorial video below). We'd love to hear what you think! We have short tutorials that cover all the features!
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Drummond Lab @drummondlab.bsky.social · 08/09/2026
We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Join us! apply.interfolio.com/191981 bcmb.uchicago.edu
A picture of the University of Chicago campus, with downtown Chicago in the distance and Lake Michigan on the horizon. The campus's central quad is pictured, a classical collegiate quad with paths and old trees and stone architecture. It's really pretty and I love it.
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Philip Ball @philipcball.bsky.social · 26/08/2026
Apologies in advance to all Danish speakers for my pronunciation in the audiobook of this. www.hachette.co.uk/titles/phili...
hachette.co.uk
The Man Who Broke Reality
'A true tour de force. A fresh, authoritative, meticulously researched and utterly engaging examination of arguably the deepest thinker of the twentieth cent...
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Jeff Lewis @lewislab.bsky.social · 30/07/2026
So many emotions right now. I had almost given up hope that this one would get funded. Feeling relief, excitement to do the science, gratitude to everyone on the inside trying to hold NIH together, survivor's guilt. All the things.
NOA for R35 MIRA: The Genetic Basis of Variation in Post-Transcriptional Regulation of Stress Defense
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Shahar Sukenik @shaharsu.bsky.social · 29/07/2026
Finally out - our work on high throughput design and characterization of disordered protein sequences 🪱🪱🪱. A long time collaboration with BFFs @alexholehouse.bsky.social and @remenecker.bsky.social, with experimental work led by @trevorbrandt.bsky.social and @karaehunt.bsky.social.
nature.com
Rational design of disordered proteins for sequence–function investigation - Nature
GOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.
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D. Allan Drummond @dadrummond.art · 29/07/2026
Got the news today that I've been promoted to Full Professor of Biochemistry & Molecular Biology at The University of Chicago. A tremendous honor, one made possible by an incredible group of trainees who I've had the pleasure of working with over the past twenty years. Best is yet to come! 🤓🔬
My bronze sculpture of a budding yeast cell, cutaway to show all the organelles and internal structures, in my open hand against a white background. My research group studies budding yeast and human cells to understand the molecular basis for how cells sense and respond to sudden changes in their environment. Now back to our regularly scheduled bug and sculpture posting!
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RedPen/BlackPen @redpenblackpen.bsky.social · 13/04/2026
thinking a lot about this cartoon this week... WHY DID I AGREE TO THOSE REVIEWS??
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Claus Wilke @clauswilke.com · 11/03/2026
New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/ www.biorxiv.org/content/10.6...
biorxiv.org
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Alex Holehouse @alexholehouse.bsky.social · 12/02/2026
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.
nature.com
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology
Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...
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Alex Holehouse @alexholehouse.bsky.social · 19/02/2026
Papers are like buses... You wait for ages, then two come along at once. Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published! www.nature.com/articles/s41...
nature.com
Accurate predictions of disordered protein ensembles with STARLING - Nature
The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.
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Jerelle Joseph @jerelleaj.bsky.social · 13/02/2026
Pablo’s work on “condensate Deborah numbers” is now out in #JCP!! Selected as Editor’s Pick and featured as a #Scilight pubs.aip.org/aip/jcp/arti...
pubs.aip.org
Molecular origins of viscoelasticity in biomolecular condensates
Biomolecular condensates are membraneless organelles that compartmentalize functions in living cells. Formed by the phase separation of biomolecules, condensate
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Eduardo Tassoni Tsuchida @eduardotassoni.bsky.social · 12/02/2026
I am excited to share the main piece of work from my PhD! In this paper, we investigated the propensities of distinct transcripts in associating with biomolecular condensates, mainly focusing on how heat-induced mRNAs escape condensation and are properly translated. www.biorxiv.org/content/10.6...
biorxiv.org
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Florent Waltz @florentwaltz.bsky.social · 10/02/2026
Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵
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Soragni:Lab @alice.soragnilab.com · 10/02/2026
Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n news.cuanschutz.edu/dbmi/cu-ansc...
news.cuanschutz.edu
CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative
CU Anschutz welcomes Alice Soragni to launch a Functional Personalized Medicine Initiative using rapid tumor organoid testing to guide treatment decisions.
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Jerelle Joseph @jerelleaj.bsky.social · 11/01/2026
Out on the #bioRxiv in collaboration with @luciastrader.bsky.social, we probe the molecular basis for thermoresponsive condensation in plants! Work led by Sunita Pathak and @ananyac2000.bsky.social 🥳🥳 www.biorxiv.org/content/10.6...
biorxiv.org
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Jerelle Joseph @jerelleaj.bsky.social · 14/01/2026
How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social
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Titus Brown @titus.idyll.org · 28/01/2026
How titus organizes computational projects: a (very) short presentation. Comments welcome ;)
hackmd.io
How titus organizes things - HackMD
tags: bcb298
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Robert McNees @mcnees.bsky.social · 04/01/2025
Physicist and mathematician Isaac Newton was born #OTD in 1643. Newton revolutionized our understanding of mathematics, mechanics, gravity, and optics. Later in life he served as warden of the Royal Mint, reforming currency and foiling counterfeiters. 🧪 🔭 ⚛️ 🪙 Portrait: B. Bramley, after G. Kneller
Painted portrait of Isaac Newton, who is looking slightly to his left. He has a long, wolffish face with a pale complexion and red lips. Newton’s hair is shoulder length and graying - the painting was made when he was 46 years old. He wears a dark coat and white shirt with a frilly collar.
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Peter Stockwell @stockwell.bsky.social · 19/12/2025
Physicist Leo Szilard, in a short science fiction story from 1948, describing how to retard science by making the funding application longer and harder than the proposed research - now called the ‘Szilard point’
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Oli Clarke @olibclarke.bsky.social · 18/12/2025
very unusual - a tRNA regulated anion channel
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Prakash Lab at Stanford @prakashlab.bsky.social · 19/12/2025
(1/n) What if you never had to make your bed? What if your laundry could fold itself? Folding is everywhere around us - but did you know that folding flat sheets are at the ❤️ of diversity of shapes in the animal world - since 500 million years ago. Our latest work: www.youtube.com/watch?v=nudC...
youtube.com
Self-folding laundry
YouTube video by PrakashLab
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Yoav Gilad @ygilad.bsky.social · 19/12/2025
Faculty position at the department of medicine, University of Chicago. Please share.
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Lukasz Bugaj @bugajlab.bsky.social · 17/12/2025
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇
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Lukasz Bugaj @bugajlab.bsky.social · 16/12/2025
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
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Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
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Matthew Hahn @3rdreviewer.bsky.social · 17/12/2025
Have you ever wondered: just how strong *is* the evidence for Muller's ratchet on mtDNA? Well, wonder no more! (Project led by Yu Mo, with @smishra677.bsky.social and @yadirapga.bsky.social) "No molecular evidence for Muller's ratchet in mitochondrial genomes" www.biorxiv.org/content/10.6...
biorxiv.org
No molecular evidence for Muller's ratchet in mitochondrial genomes
Muller's ratchet predicts that non-recombining genomes can accumulate deleterious mutations, though molecular evidence for it is rare. Previous studies have tried to detect ratchet-like behavior in mi...
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Claus Wilke @clauswilke.com · 11/12/2025
Become a colleague in my department! Applications close in four days, December 15.
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Drummond Lab @drummondlab.bsky.social · 04/12/2025
Incredible thread
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Robert McNees @mcnees.bsky.social · 04/12/2024
"I, at any rate, am convinced that He is not playing at dice." Einstein sent a letter to Max Born #OTD in 1926, in which he gave his oft-quoted objection to the probabilistic interpretation of the wavefunction in quantum mechanics. 🧪 ⚛️ You may be surprised by where this is headed. (1/n)
pubs.aip.org
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Maitreya Dunham @maitreya.bsky.social · 25/11/2025
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
biorxiv.org
The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations
Most mutations are neutral or deleterious, and mutator alleles that increase the mutation rate of an organism are considered rare and short-lived. Here, we report a genomic signature consistent with t...
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Zwicker Group @zwickergroup.bsky.social · 21/11/2025
Our review on the physics of phase separation in cells has been published by Rep. Prog. Phys. 🎉 doi.org/10.1088/1361... We hope that the text and citations are helpful for anyone interested in physical descriptions of condensates in cells!
doi.org
Physics of droplet regulation in biological cells - IOPscience
Physics of droplet regulation in biological cells, Zwicker, David, Paulin, Oliver W, ter Burg, Cathelijne
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Michael Baym @baym.lol · 20/11/2025
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...
science.org
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
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Josh Riback @superscijew.bsky.social · 04/11/2025
(2/10) We found that disparate drivers of acute myeloid leukemia (AML) – including NPM1c, KMT2A-r, and nucleoporin oncofusions – form nuclear condensates with a shared set of proteins including XPO1 and MENIN to drive leukemic gene expression (e.g. HOXA). www.cell.com/cell/fulltex...
cell.com
Disparate leukemia mutations converge on nuclear phase-separated condensates
Mutant NPM1 and various leukemia oncofusions form biophysically indistingishable nuclear condensates, termed C-bodies, which orchestrate leukemogenic gene expression. These findings consolidate divers...
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Josh Riback @superscijew.bsky.social · 04/11/2025
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
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Claus Wilke @clauswilke.com · 13/11/2025
My department at UT Austin is looking to hire an Assistant Professor in Evolutionary Biology, broadly defined. Feel free to reach out to me with any questions you may have. apply.interfolio.com/177547
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Drummond Lab @drummondlab.bsky.social · 11/11/2025
Happy that our paper just got accepted. Also happy that it's been available as a preprint for more than 1.5 years on @biorxivpreprint.bsky.social, updated 3x with new experiments, with >7,500 full-text downloads and 20 citations. Before publication. www.biorxiv.org/content/10.1...
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Brett Baker @archaeal.bsky.social · 10/11/2025
A wonderful collaboration between my lab and Andy Ellington and Edward Marcotte here at UT. We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
academic.oup.com
Plastic degradation by enzymes from uncultured deep sea microorganisms
Abstract. Polyethylene terephthalate (PET)-hydrolyzing enzymes (PETases) are a recently discovered enzyme class capable of plastic degradation. PETases are
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Oded Rechavi @odedrechavi.bsky.social · 06/11/2025
Please read the thoughtful Blog that @richardsever.bsky.social and the @openrxiv.bsky.social team wrote on integrating pre-prints with AI review openrxiv.org/enabling-rev...
openrxiv.org
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
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Richard Sever @richardsever.bsky.social · 06/11/2025
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...
openrxiv.org
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
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Drug Monkey @drugmonkey.bsky.social · 03/11/2025
Slightly less snarkily, manuscript review culture varies a lot. If a person trained in GlamHoundery reviews for a real journal they often are slightly out of step in their demands. So an important editorial function is to enforce the culture of their journal. By saying “nah don’t do all that”.
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Drummond Lab @drummondlab.bsky.social · 28/10/2025
As an author, I frequently encounter reviewers who should be overruled -- gatekeepers. My main complaint is has been that many editors do not have the confidence/expertise to do so (but some do). a) Thank goodness for preprints, b) I review with the expectation that the paper will be published.
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The Economist @economist.com · 25/10/2025
“It’s too easy to be swamped by a short-term political and social environment.” Neil Shubin tells “Babbage” why he remains optimistic about science in America
econ.st
Neil Shubin: defender of American science
Our podcast on science and technology. We speak to the polar palaeontologist poised to lead America’s National Academy of Sciences
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