Iron is an essential element required for critical processes such as oxygen transport, energy generation, and DNA synthesis. To be incorporated as a cofactor, iron that is stored in the cytosol within...

Advertising Summary: Virginia Commonwealth University (VCU) School of Medicine is a premier academic medical center located in the heart of Richmond. Accounting for almost half of VCU’s sponsored rese...

Love them or hate them, site visits have been a part of the culture of NCI-designated cancer centers for decades, shaping the process for admitting members to the elite club and influencing internal politics within institutions. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with […]

The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

Anthony G. Letai, a physician-scientist at Harvard Medical School and Dana-Farber Cancer Institute whose research is focused on apoptosis and functional diagnostics, has been tapped by the Trump administration to become the 18th director of the National Cancer Institute. To access this subscriber-only content please log in or subscribe.If your institution has a site license, […]

Dr. Letai will serve as NCI’s 18th director.

Anthony G. Letai, a physician-scientist at Harvard Medical School and Dana-Farber Cancer Institute whose research is focused on apoptosis and functional diagnostics, has been tapped by the Trump administration to become the 18th director of the National Cancer Institute. To access this subscriber-only content please log in or subscribe.If your institution has a site license, […]

An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This study identifies C26 ceramide and CERS3 as critical factors in colorectal cancer progression, which is modulated by microbial metabolite riboflavin. C26 ceramide directly activates EGFR, and the ...

City of Hope is using generative artificial intelligence to create operational efficiency, enable AI-driven patient personalization, improve access to clinical trials, and empower breakthrough research. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are […]

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and t...

With advances in treatment and screening for earlier detection, oncologists have improved cancer survival rates dramatically. That is excellent news, but the surging number of survivors means it is increasingly important for providers to focus more diligently on what patients need to thrive after treatment. To access this subscriber-only content please log in or subscribe.If […]

Many years ago I started blogging about the NIH system of extramural grant award because of my own frustrations with the system, as it appeared to be to me. Over time, I realized that there were a …

The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target...

The cancer center program of the NCI is a success that is admired not only within the NIH but worldwide. This is due, in large part, to the cancer center review process that has evolved and strengthen...

Gurung et al. show that young subcutaneous adipocytes provide lipids and phosphatidylcholine to melanoma cells, which activates PI3K-AKT, OXPHOS, and oxidative stress. High OXPHOS reduces metastatic b...

One of my favourite uses of social media is sharing (and discovering) new preprints that seem relevant for my field. Rewardingly, posting preprints is

Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes

W. Kimryn Rathmell, former director of the NCI, has accepted the role as CEO of The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James). To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in […]

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

In an email sent to directors and deputy directors of NCI-designated cancer centers, Krzysztof Ptak, director of the NCI Office of Cancer Centers, provided a comparison between the newly issued Cancer Center Support Grant Notice of Funding Opportunity with the previous version of the document. To access this subscriber-only content please log in or subscribe.If […]