Iron abundance alone does not determine ferroptosis sensitivity. In this issue of Cell, Sharma and colleagues identify polyamines as endogenous metabolic buffers that reduce the chemical accessibility...

A California bill would give voters the chance to vote on whether the state should create a $23 billion bond that would be used to award grants to university researchers.

After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

Nature Structural & Molecular Biology, Published online: 13 March 2026; doi:10.1038/s41594-026-01760-4The oxidoreductase FSP1 recycles radical-trapping antioxidants that suppress oxidative lipid damage and ferroptosis. A series of genetic screens reveal a key role for the vitamin B2 metabolite flavin adenine dinucleotide in stabilizing FSP1, preventing its proteasomal degradation and promoting ferroptosis suppression.

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice.

Imbalances in lipid storage and secretion lead to the accumulation of hepatocyte lipid droplets (LDs) (i.e., hepatic steatosis). Our understanding of the mechanisms that govern the channeling of hepat...

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...

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FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...

Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipi...

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Check out their lectures at the annual meeting in March in the Washington, D.C., metro area.

Check out their lectures at the annual meeting in March in the Washington, D.C., metro area.

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to cell...

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...

The award recognizes the biochemist for discoveries on ribozyme function and CRISPR gene editing, and international science leadership