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The Cancer Letter

@cancerletter.com
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The leading independent source for information on the issues that shape oncology since 1973. cancerletter.com

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The Cancer Letter @cancerletter.com · 2h
NCI launches AI tool to help match patients to clinical trials cancerletter.com/cancer-policy/2026…
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The Cancer Letter @cancerletter.com · 4h
Erin Geddis Cummings, Bradley Zebrack receive Cancer Nation’s 2026 Ellen L. Stovall Award cancerletter.com/in-brief/20260925_…
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Erin Geddis Cummings, Bradley Zebrack receive Cancer Nation’s 2026 Ellen L. Stovall Award - The Cancer Letter
Cancer Nation has awarded the following honorees with the 2026 Ellen L. Stovall Award To access this subscriber-only con
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The Cancer Letter @cancerletter.com · 5h
Though the plan has been set aside, its emergence is noteworthy, because it points to fissures between OMB and NIH. cancerletter.com/news-analysis/2026…
cancerletter.com
Trump weighs—and abandons—an executive order that would give OMB veto power over NIH grants - The Cancer Letter
The White House last week considered, but ultimately abandoned, a plan to create a panel that would review NIH grants in
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The Cancer Letter @cancerletter.com · 7h
FDA grants Priority Review to perioperative IMFINZI + enfortumab vedotin for muscle-invasive bladder cancer cancerletter.com/drugs-and-targets/…
cancerletter.com
FDA grants Priority Review to perioperative IMFINZI + enfortumab vedotin for muscle-invasive bladder cancer - The Cancer Letter
FDA has granted Priority Review for IMFINZI (durvalumab) in combination with enfortumab vedotin for the treatment of pat
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The Cancer Letter @cancerletter.com · 21h
"We must not lower the bar for approvals and introduction into the population regardless of how desperate we are for solutions,” NCI's Philip Castle said at the meeting. cancerletter.com/news-analysis/2026…
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The Cancer Letter @cancerletter.com · 23h
HHS issues direct final rule to reduce reliance on animal testing cancerletter.com/cancer-policy/2026…
cancerletter.com
HHS issues direct final rule to reduce reliance on animal testing - The Cancer Letter
FDA has issued a direct final rule that changes the language in its regulations so that “animal testing” is no longer de
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The Cancer Letter @cancerletter.com · 29/09/2026
PDS0101 + pembrolizumab in HPV16+ R/M head and neck cancer show anti-tumor activity, VERSATILE-002 phase II study finds cancerletter.com/clinical-roundup/2…
cancerletter.com
PDS0101 + pembrolizumab in HPV16+ R/M head and neck cancer show anti-tumor activity, VERSATILE-002 phase II study finds - The Cancer Letter
PDS0101 plus pembrolizumab showed antitumor activity in ICI-naive HPV16-positive R/M HNSCC, according to the results of
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The Cancer Letter @cancerletter.com · 29/09/2026
"One of the most important advances has been our growing ability to understand the biology of each patient’s cancer and use those insights to guide treatment decisions more precisely," writes @cityofhope.bsky.social's Hope Rugo. cancerletter.com/sponsored-article/…
cancerletter.com
How biology is reshaping breast cancer care - The Cancer Letter
Breast cancer treatment has changed dramatically over the past decade. One of the most important advances has been our g
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The Cancer Letter @cancerletter.com · 29/09/2026
Rutika Mehta named director of upper GI medical oncology at NYU cancerletter.com/in-brief/20260925_…
cancerletter.com
Rutika Mehta named director of upper GI medical oncology at NYU - The Cancer Letter
Rutika Mehta has joined NYU Langone Health’s Perlmutter Cancer Center as director of upper GI medical oncology. To acces
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The Cancer Letter @cancerletter.com · 29/09/2026
Raja Flores: "When did cancer that had already spread to lymph nodes become early-stage cancer?" cancerletter.com/perspective/202609…
cancerletter.com
When did stage 3B lung cancer become “early stage”? - The Cancer Letter
My recent column about Merck’s television commercial for perioperative Keytruda left me with a question I could not shak
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The Cancer Letter @cancerletter.com · 28/09/2026
Cancer Grand Challenges, through the Torrey Coast Foundation and Cancer Research UK, commits up to $34M to gastroesophageal cancer research cancerletter.com/funding-opportunit…
cancerletter.com
Tagrisso increased OS in early-stage EGFR-mutated lung cancer at eight year follow-up, ADAURA phase III trial finds - The Cancer Letter
Tagrisso (osimertinib) demonstrated a sustained, clinically meaningful overall survival benefit at eight years compared
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The Cancer Letter @cancerletter.com · 28/09/2026
Raghu Kalluri (@utmbhealth.bsky.social): "People have seen how teams that play well together succeed in the end, winning a game—versus having one or two superstars. And I think that’s what comprehensive cancer care is." cancerletter.com/podcastc/20260925_1
cancerletter.com
The Directors: Two Gulf Coast cancer center directors on why NCI designation matters—and why they want it Lucio Miele and Raghu Kalluri: Science and technology have changed what an aspiring cancer center must accomplish - The Cancer Letter
What should a cancer center look like in an era of AI, genomics, complex patient populations, rising costs, and declinin
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The Cancer Letter @cancerletter.com · 28/09/2026
UNM Comprehensive Cancer Center (@unm.edu) earns NCI redesignation cancerletter.com/in-brief/20260925_…
cancerletter.com
UNM Comprehensive Cancer Center earns NCI redesignation - The Cancer Letter
The University of New Mexico Comprehensive Cancer Center has received redesignation as an NCI Comprehensive Cancer Cente
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The Cancer Letter @cancerletter.com · 28/09/2026
The White House considered, but ultimately abandoned, a plan to create a panel that would review NIH grants in an effort to weed out projects the administration regards as “woke.” cancerletter.com/news-analysis/2026…
cancerletter.com
Trump weighs—and abandons—an executive order that would give OMB veto power over NIH grants - The Cancer Letter
The White House last week considered, but ultimately abandoned, a plan to create a panel that would review NIH grants in
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The Cancer Letter @cancerletter.com · 28/09/2026
Tagrisso increased OS in early-stage EGFR-mutated lung cancer at eight year follow-up, ADAURA phase III trial finds cancerletter.com/clinical-roundup/2…
cancerletter.com
FDA approves Lyrfigtu for previously treated, unresectable, locally advanced or metastatic cholangiocarcinoma - The Cancer Letter
FDA granted approval for Lyrfigtu (lirafugratinib) as a treatment option for patients with cholangiocarcinoma with FGFR2
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The Cancer Letter @cancerletter.com · 27/09/2026
FDA approves belzutifan in combination with lenvatinib for advanced RCC with a clear cell component cancerletter.com/drugs-and-targets/…
cancerletter.com
FDA approves belzutifan in combination with lenvatinib for advanced RCC with a clear cell component - The Cancer Letter
FDA has approved belzutifan (Welireg) in combination with lenvatinib (Lenvima) for adults with advanced renal cell carci
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The Cancer Letter @cancerletter.com · 27/09/2026
Trump administration pulls 750,000 people from ACA coverage, claiming fraud cancerletter.com/cancer-policy/2026…
cancerletter.com
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The Cancer Letter @cancerletter.com · 27/09/2026
FDA approves Lyrfigtu for previously treated, unresectable, locally advanced or metastatic cholangiocarcinoma cancerletter.com/drugs-and-targets/…
cancerletter.com
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The Cancer Letter @cancerletter.com · 26/09/2026
In a long-anticipated decision, the FDA Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee voted in favor of Galleri to become the first multi-cancer detection test to receive regulatory approval. cancerletter.com/news-analysis/2026…
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The Cancer Letter @cancerletter.com · 26/09/2026
How biology is reshaping breast cancer care. @cityofhope.bsky.social's Hope S. Rugo on how our growing understanding is helping make personalized cancer care a reality cancerletter.com/sponsored-article/…
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The Cancer Letter @cancerletter.com · 26/09/2026
When did stage 3B lung cancer become “early stage”? A new Perspective from Raja M. Flores, MD, MPH cancerletter.com/perspective/202609…
cancerletter.com
When did stage 3B lung cancer become “early stage”? - The Cancer Letter
My recent column about Merck’s television commercial for perioperative Keytruda left me with a question I could not shak
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The Cancer Letter @cancerletter.com · 26/09/2026
At confirmation hearing, Heidi Overton sidesteps questions about FDA regulation of fruit-flavored vapes cancerletter.com/cancer-policy/2026…
cancerletter.com
At confirmation hearing, Heidi Overton sidesteps questions about FDA regulation of fruit-flavored vapes - The Cancer Letter
Heidi Overton, President Trump’s nominee for FDA Commissioner, defended the agency’s recent policy decisions reversing i
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The Cancer Letter @cancerletter.com · 26/09/2026
Trump weighs—and abandons—an executive order that would give OMB veto power over NIH grants cancerletter.com/news-analysis/2026…
cancerletter.com
Trump weighs—and abandons—an executive order that would give OMB veto power over NIH grants - The Cancer Letter
The White House last week considered, but ultimately abandoned, a plan to create a panel that would review NIH grants in
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The Cancer Letter @cancerletter.com · 26/09/2026
Rather than treating the current revolution in science and medicine as a threat, Kalluri (@utmbhealth.bsky.social) and Miele (LSU-LCMC Health) see it as an opportunity to do more than just replicate existing models. cancerletter.com/podcastc/20260925_1
cancerletter.com
The Directors: Two Gulf Coast cancer center directors on why NCI designation matters—and why they want it Lucio Miele and Raghu Kalluri: Science and technology have changed what an aspiring cancer center must accomplish - The Cancer Letter
What should a cancer center look like in an era of AI, genomics, complex patient populations, rising costs, and declinin
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The Cancer Letter @cancerletter.com · 25/09/2026
FDA advisory committee votes in favor of Galleri approval, but calls for removal of “early” detection claims. Clinical benefit will not be considered for approval, FDA says. cancerletter.com/news-analysis/2026…
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The Cancer Letter @cancerletter.com · 25/09/2026
The Directors: Two Gulf Coast cancer center directors on why NCI designation matters—and why they want it. Lucio Miele and Raghu Kalluri: Science and technology have changed what an aspiring cancer center must accomplish. cancerletter.com/podcastc/20260925_1
cancerletter.com
The Directors: Two Gulf Coast cancer center directors on why NCI designation matters—and why they want it Lucio Miele and Raghu Kalluri: Science and technology have changed what an aspiring cancer center must accomplish - The Cancer Letter
What should a cancer center look like in an era of AI, genomics, complex patient populations, rising costs, and declinin
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The Cancer Letter @cancerletter.com · 24/09/2026
Kalil Abdullah to lead @northwellhealth.bsky.social's brain tumor program cancerletter.com/in-brief/20260918_…
cancerletter.com
Kalil Abdullah to lead Northwell’s brain tumor program - The Cancer Letter
Northwell Health and the Northwell Cancer Institute have appointed Kalil Abdullah as system director of Central Nervous
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The Cancer Letter @cancerletter.com · 24/09/2026
"When a leader like Dr. Freeman passes, we feel that loss deeply. Yet his legacy endures, challenging us to carry that work forward," Robert Winn said to The Cancer Letter. cancerletter.com/obituary/20260918_5
cancerletter.com
Harold Freeman, a surgeon who championed health equity, dies at 93 Freeman, the father of patient navigation, served as president of ACS and chair of the President’s Cancer Panel - The Cancer Letter
Harold P. Freeman, a surgeon who started his career in Harlem, where, in addition to performing surgeries, he pioneered
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The Cancer Letter @cancerletter.com · 23/09/2026
Cancer biosimilars associated with lower costs for insurers and patients, UCLA study finds cancerletter.com/clinical-roundup/2…
cancerletter.com
Cancer biosimilars associated with lower costs for insurers and patients, UCLA study finds - The Cancer Letter
Biologic drugs play an important role in treating cancers such as breast cancer and lymphoma, but their high costs can a
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The Cancer Letter @cancerletter.com · 23/09/2026
Letai shares weekly musings in NCI’s new “Tuesdays with Tony” series cancerletter.com/cancer-policy/2026…
cancerletter.com
Letai shares weekly musings in NCI’s new “Tuesdays with Tony” series - The Cancer Letter
This summer, NCI launched a weekly social media series hosted by Director Anthony Letai. To access this subscriber-only
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The Cancer Letter @cancerletter.com · 23/09/2026
Edward Kaftan named associate director for administration and scientific affairs at Dartmouth cancerletter.com/in-brief/20260918_…
cancerletter.com
Edward Kaftan named associate director for administration and scientific affairs at Dartmouth - The Cancer Letter
Edward Kaftan will join Dartmouth Cancer Center  as the associate director for administration and scientific affairs. To
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The Cancer Letter @cancerletter.com · 23/09/2026
"This is not a scientific problem. It is a policy problem. And it is one we can change," write NBCC's Frances M. Visco, JD and Michelle Tregear cancerletter.com/perspective/202609…
cancerletter.com
Scientific progress can’t help people if they can’t access care This is a policy problem. And it is one we can change. - The Cancer Letter
Scientific advances have produced therapies that allow some people with metastatic breast cancer to live longer and bett
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The Cancer Letter @cancerletter.com · 22/09/2026
"Adding people feels good at first, until we realize it’s shuffling tasks and dividing workloads rather than delivering real gains in scalability and efficiency for the program," writes Yunu's Jeff Sorenson. cancerletter.com/sponsored-article/…
cancerletter.com
The end of “more money, more people, more trials” Cancer centers are being asked to grow their portfolios on flat budgets. Headcount is the wrong answer. - The Cancer Letter
Congress settled the FY26 question in February, with NCI receiving $7.352 billion, an increase of $128 million over the
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The Cancer Letter @cancerletter.com · 22/09/2026
Cancer centers continue to face recurring drug shortages, NCCN survey finds cancerletter.com/cancer-policy/2026…
cancerletter.com
Cancer centers continue to face recurring drug shortages, NCCN survey finds - The Cancer Letter
Every cancer center surveyed by by the National Comprehensive Cancer Network was experiencing a shortage of at least one
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The Cancer Letter @cancerletter.com · 22/09/2026
EGFR mutation linked to dramatically increased lung cancer risk cancerletter.com/clinical-roundup/2…
cancerletter.com
EGFR mutation linked to dramatically increased lung cancer risk - The Cancer Letter
A rare inherited mutation in the Epidermal Growth Factor Receptor gene is associated with a 25-fold increased risk of lu
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The Cancer Letter @cancerletter.com · 22/09/2026
D. Neil Hayes to lead OSUCCC’s Institute for Precision Cancer Medicine cancerletter.com/in-brief/20260918_…
cancerletter.com
D. Neil Hayes to lead OSUCCC’s Institute for Precision Cancer Medicine - The Cancer Letter
D. Neil Hayes, has been appointed director of the Institute for Precision Cancer Medicine, effective Sept. 14. Hayes wil
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The Cancer Letter @cancerletter.com · 22/09/2026
States are not required to adopt the new procedures, which means the manner in which medical frailty—and with it, the waiving of the work requirement—is assessed will likely differ from state to state. cancerletter.com/health-equity/2026…
cancerletter.com
As Medicaid work requirements loom, CMS guidance offers automatic exemptions for some cancer patients Caveat: The guidance is optional. Will states opt in? - The Cancer Letter
The Centers for Medicare & Medicaid Services has published a guidance that spells out a process for states to use to exe
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The Cancer Letter @cancerletter.com · 21/09/2026
As of the end of August, NCI has selected 1,891 competing awards for funding this fiscal year, all of which will be funded by the year’s end, NCI Director Anthony G. Letai said to the National Cancer Advisory Board. cancerletter.com/nci/20260918_1
cancerletter.com
Letai takes a swipe at “ill-informed commentators,” as he lays out his scientific vision for NCI “To my knowledge, 100% of grants that clear my desk get funded” - The Cancer Letter
As of the end of August, NCI has selected 1,891 competing awards for funding this fiscal year, all of which will be fund
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The Cancer Letter @cancerletter.com · 21/09/2026
Senthil K. Muthuswamy named director of NCI’s Center for Cancer Research cancerletter.com/in-brief/20260918_…
cancerletter.com
Senthil K. Muthuswamy named director of NCI’s Center for Cancer Research - The Cancer Letter
Following a national search, NCI has selected Senthil K. Muthuswamy as the next director of the Center for Cancer Resear
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The Cancer Letter @cancerletter.com · 21/09/2026
@nbccstopbc.bsky.social: "Even after SSDI and Medicare eligibility has been established, individuals must wait a total of 29 months—meaning patients with a median survival of three years post-diagnosis must wait nearly 2.5 years for health coverage." cancerletter.com/perspective/202609…
cancerletter.com
Scientific progress can’t help people if they can’t access care This is a policy problem. And it is one we can change. - The Cancer Letter
Scientific advances have produced therapies that allow some people with metastatic breast cancer to live longer and bett
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The Cancer Letter @cancerletter.com · 21/09/2026
@ascocancer.bsky.social expresses support for functional precision medicine, rescinding past objections cancerletter.com/clinical-roundup/2…
cancerletter.com
ASCO expresses support for functional precision medicine, rescinding past objections - The Cancer Letter
The American Society of Clinical Oncology has expressed support for the advancement of functional precision medicine.  T
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The Cancer Letter @cancerletter.com · 20/09/2026
FDA approves imlunestrant + abemaciclib for ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer cancerletter.com/drugs-and-targets/…
cancerletter.com
FDA approves imlunestrant + abemaciclib for ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer - The Cancer Letter
FDA approved imlunestrant (Inluriyo) in combination with abemaciclib (Verzenio), for adults with estrogen receptor (ER)-
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The Cancer Letter @cancerletter.com · 20/09/2026
U.S. cancer death rate declined 35% since 1991, @theaacr.bsky.social Cancer Progress Report finds cancerletter.com/cancer-policy/2026…
cancerletter.com
U.S. cancer death rate declined 35% since 1991, AACR Cancer Progress Report finds - The Cancer Letter
The American Association for Cancer Research has released the AACR Cancer Progress Report 2026.  To access this subscrib
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The Cancer Letter @cancerletter.com · 20/09/2026
"As a young NCI staffer to the President’s Cancer Panel, I distinctly remember Freeman telling a well-known and influential Black congressman to 'shut up,' as his rhetoric was supportive of arguments for racial genetic inferiority," Otis Brawley said. cancerletter.com/obituary/20260918_5
cancerletter.com
Harold Freeman, a surgeon who championed health equity, dies at 93 Freeman, the father of patient navigation, served as president of ACS and chair of the President’s Cancer Panel - The Cancer Letter
Harold P. Freeman, a surgeon who started his career in Harlem, where, in addition to performing surgeries, he pioneered
011
The Cancer Letter @cancerletter.com · 20/09/2026
FDA grants accelerated approval to sevabertinib for locally advanced or metastatic non-squamous NSCLC cancerletter.com/drugs-and-targets/…
cancerletter.com
FDA grants accelerated approval to sevabertinib for locally advanced or metastatic non-squamous NSCLC - The Cancer Letter
FDA has granted accelerated approval to sevabertinib (Hyrnuo), a kinase inhibitor, for adult patients with locally advan
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The Cancer Letter @cancerletter.com · 19/09/2026
“Cancer patients and survivors, and other enrollees, are scared they are going to lose their Medicaid coverage regardless of whether they’re able to meet all requirements and deadlines," ASCO board chair Robin Zon said to The Cancer Letter. cancerletter.com/health-equity/2026…
cancerletter.com
As Medicaid work requirements loom, CMS guidance offers automatic exemptions for some cancer patients Caveat: The guidance is optional. Will states opt in? - The Cancer Letter
The Centers for Medicare & Medicaid Services has published a guidance that spells out a process for states to use to exe
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The Cancer Letter @cancerletter.com · 19/09/2026
"The end of 'more money, more people, more trials'. Cancer centers are being asked to grow their portfolios on flat budgets. Headcount is the wrong answer," writes Jeff Sorenson, CEO and co-founder of Yunu cancerletter.com/sponsored-article/…
cancerletter.com
The end of “more money, more people, more trials” Cancer centers are being asked to grow their portfolios on flat budgets. Headcount is the wrong answer. - The Cancer Letter
Congress settled the FY26 question in February, with NCI receiving $7.352 billion, an increase of $128 million over the
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The Cancer Letter @cancerletter.com · 19/09/2026
Kennedy overhauls “too woke” USPSTF with the appointment of eight members. Critics say new members will politicize, commercialize the panel. cancerletter.com/cancer-policy/2026…
cancerletter.com
Kennedy overhauls “too woke” USPSTF with the appointment of eight members Critics say new members will politicize, commercialize the panel - The Cancer Letter
HHS Secretary Robert F. Kennedy, Jr., through the Agency for Healthcare Research and Quality, has announced the addition
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The Cancer Letter @cancerletter.com · 19/09/2026
Scientific progress can’t help people if they can’t access care This is a policy problem. And it is one we can change. By nbccstopbc.bsky.social's Fran Visco and Michelle Treger cancerletter.com/perspective/202609…
cancerletter.com
Scientific progress can’t help people if they can’t access care This is a policy problem. And it is one we can change. - The Cancer Letter
Scientific advances have produced therapies that allow some people with metastatic breast cancer to live longer and bett
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The Cancer Letter @cancerletter.com · 19/09/2026
Letai: “We're in a very healthy state right now. I have no doubt that we're closing the gap between the awards being given and the selections being made. I have no doubt that we will spend our entire extramural budget by the end of this year." cancerletter.com/nci/20260918_1
cancerletter.com
Letai takes a swipe at “ill-informed commentators,” as he lays out his scientific vision for NCI “To my knowledge, 100% of grants that clear my desk get funded” - The Cancer Letter
As of the end of August, NCI has selected 1,891 competing awards for funding this fiscal year, all of which will be fund
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