A research team from the University of Cologne has identified a new approach for treating particularly aggressive pancreatic cancer. It makes use of a genetic mutation that allows the immune system to...

Nature Communications - The regulatory roles of oncogenic KRAS in cell death pathways remain poorly understood. Here the authors report that KRAS induces a type I interferon response that primes...

Wissenschaftler*innen aus Köln haben ein Autonomes agentenbasiertes KI-System namens SPARK entwickelt, welches als „digitales Gehirn“ fungiert

BackgroundFerroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation and membrane rupture. While cellular populations r...

Wissenschaftler der Universität zu Köln haben einen neuen Mechanismus entdeckt, der es ermöglicht, dass eine der aggressivsten Formen von Lungenkrebs der Behandlung entgeht, und eröffnet damit neue Mö...

Caspase 8 protein expression is largely absent in small cell lung cancer (SCLC) patients. Here, the authors generate a caspase 8 deletion SCLC mouse model and show that it promotes a neuronal progenit...

Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)

Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

CECAD congratulates Professor Aleksandra Trifunovic on receiving the University of Cologne’s Max Delbrück Prize for her pioneering contributions to mitochondrial biology.

Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes

Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation

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