The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...

A Harvard Chan School study offers new ways to understand cancer and its vulnerabilities, and suggests that certain protein inhibitors could potentially be effective treatments for the disease.

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

New Article! Spontaneous and experimental models of lymph node metastasis https://bit.ly/4fzWoAj

Nature Protocols, Published online: 13 August 2025; doi:10.1038/s41596-025-01200-5We provide two procedures to cover distinct approaches for the initiation of lymph node metastases in mice: one for studying the metastatic cascade in tumorigenic cells and the other for studying the effect of metastatic formations in the host.

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

A burgeoning approach to treat cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting anti-ferroptotic pathways in the broader tumor microe...

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Abstract. The balance between reactive oxygen species (ROS) and antioxidant defenses plays a critical role in tumor development, progression, and response to therapy. However, the detection of ROS in ...

Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

Stanford University is seeking a Life Science Research Professional 1 to perform basic functions and activities involved in defined research projects....

Harvard Chan faculty conduct groundbreaking research that has led directly to lifesaving vaccines, treatments, policies, and programs.

The Department of Molecular Metabolism researches the complex interplay between genetics, environment, and metabolic processes at the molecular level to understand how deviations can lead to widesprea...

Nature Protocols - An approach to collect lymph drained from the primary tumor in mice enables the downstream characterization of the samples using metabolomics, lipidomics and flow cytometry.