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Juan S. Bonifacino

@juanbonifacino.bsky.social
1.6K followers 840 following 66 posts

Cell biologist at NIH researching mechanisms of protein and organelle transport, and related diseases. Special interest in neurons and neurodevelopmental disorders. Science, nature, travel, and music enthusiast. Views are my own.

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Reposted by Juan S. Bonifacino
Nobel Prize @nobelprize.org · 25/08/2026
The only laureate to have been awarded two Nobel Prizes in two different scientific categories. The first Nobel Prize laureate to receive two prizes. The first woman to be awarded a Nobel Prize. Her name was Marie Skłodowska Curie and she made history.
Portrait of Marie Skłodowska Curie. She sits in a chair, posing for a formal portrait. She is wearing a dark dress with a detailed, patterned collar. The backdrop is a softly blurred interior setting with draped curtains.
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Mary Munson @marymunson4.bsky.social · 26/08/2026
Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).
umassmed.edu
Munson Lab | Home | BMB | UMass Chan Medical School
The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...
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Juan S. Bonifacino @juanbonifacino.bsky.social · 11/08/2026
I was recently in Colombia, and today’s earthquake feels especially close to home. My thoughts are with all the wonderful people I met during my trip, and with everyone affected. I hope they and their loved ones are safe. ❤️🇨🇴
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Juan S. Bonifacino @juanbonifacino.bsky.social · 03/08/2026
Back from beautiful and friendly Colombia ♥️ 🇨🇴
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Juan S. Bonifacino @juanbonifacino.bsky.social · 23/07/2026
New study from our lab at NICHD, NIH! We identify TBC1D9 and TBC1D9B as novel ARL8 effectors that suppress exosome secretion by inactivating RAB11A and thus blocking exocyst-dependent fusion of multivesicular endosomes with the plasma membrane. www.pnas.org/doi/10.1073/...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 24/05/2026
By the way, @dshb-antibodies.bsky.social is a non-profit that sells quality antibodies to many proteins at exceptionally reasonable prices, without AI generated faux-validation images. Check them out. dshb.biology.uiowa.edu
dshb.biology.uiowa.edu
Developmental Studies Hybridoma Bank - DSHB
High quality, low cost antibodies.
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fravery.bsky.social @fravery.bsky.social · 27/04/2026
In Gentle Light Kaoru Yamada
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Juan S. Bonifacino @juanbonifacino.bsky.social · 26/04/2026
Awesome achievement! Sabastian Sawe of Kenya becomes first person to run a sub-2-hour marathon to win in London apnews.com/article/mara...
apnews.com
Sabastian Sawe of Kenya becomes first person to run a sub-2-hour marathon to win in London
Sabastian Sawe of Kenya has become the first person to break the fabled 2-hour barrier in the marathon in a huge moment in sports history.
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Juan S. Bonifacino @juanbonifacino.bsky.social · 25/04/2026
Many thanks, @depaceraffa.bsky.social! I am deeply honored by this recognition and grateful to all who made it possible. 🙏
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Juan S. Bonifacino @juanbonifacino.bsky.social · 24/04/2026
New work from Niccolo Mencacci @feinberg.northwestern.edu et al., with contribution from @depaceraffa.bsky.social in our lab at the NIH, identifies pathogenic variants in BORCS5, encoding a subunit of the BORC complex, as a cause of a severe neurodevelopmental disorder. www.jci.org/articles/vie...
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BioImaging North America @bioimagingna.bsky.social · 13/04/2026
#HappyMicroscopyMonday #microscopycommunity- Wayne S. Rasband Open Source Imaging Award recognizes individuals advancing open source imaging software or hardware by making tools freely accessible, modifiable, and impactful. Nominate or apply by May 1, 2026! buff.ly/5DYr7UO
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Juan S. Bonifacino @juanbonifacino.bsky.social · 06/04/2026
One of the highlights of my recent trip to Argentine Patagonia: hiking to Emerald Lake in Tierra del Fuego. 🥾🏔️
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Art & Nature @capecodfairytales.bsky.social · 02/04/2026
#CapeCod #Poetry #Painting #Spring It is morning, and again I am the lucky person to be in it Mary Oliver 🎨 Kaoru Yamada
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Juan S. Bonifacino @juanbonifacino.bsky.social · 31/03/2026
Sharing the announcement of this great conference @HHMIJanelia Cell Biology of Neurons and Circuits III www.janelia.org/you-janelia/...
janelia.org
Cell Biology of Neurons and Circuits III
Organizers Jennifer Lippincott-Schwartz, HHMI/Janelia Research Campus Timothy Ryan, Weill Cornell University Gerry Rubin, HHMI/Janelia Research Campus Kang Shen, HHMI/Stanford University Jiefu Li,
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Raffaella De Pace @depaceraffa.bsky.social · 26/03/2026
Take a look at our Research Highlight: Adriana Golding et al. www.nature.com/articles/s41... We highlight the work by Ghoochani et al., who generated an atlas of brain lysosomal proteins and identified SLC45A1-associated disease as a lysosomal disorder: www.cell.com/cell/fulltex...
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Juan S. Bonifacino @juanbonifacino.bsky.social · 25/03/2026
New from @depaceraffa.bsky.social from our lab #NICHD #NIH with Carlos Dominguez-Gonzalez, Adeline Vanderver @childrensphila.bsky.social et al.: pathogenic BLOC1S1 variants disrupt BLOC-1/BORC complexes in children with severe neurodevelopmental disorder authors.elsevier.com/c/1mqGAgeXHm-E
AlphaFold prediction of BORC showing the pathogenic mutations in the BLOC1S1 subunit in children with a neurodevelopmental disorder
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Reposted by Juan S. Bonifacino
Colin's Viewfinder @colinrichardsphoto.bsky.social · 24/02/2026
My picture for today's theme for #birdoftheday #powerpose is this female Kingfisher at Forest Farm NR. 24/02/26. 🪶 #birdingwales #ukbirding
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Reposted by Juan S. Bonifacino
mattrasband.bsky.social @mattrasband.bsky.social · 20/02/2026
Fluorescence Friday - DNA-PAINT imaging of axon initial segment TRIM46 ('cyan') and bIV spectrin ('red') by the incomparable Allison Melton in my laboratory. Just spectacular!
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Reposted by Juan S. Bonifacino
Michael Way @drmichaelway.bsky.social · 05/02/2026
Two postdoc positions in way lab go live tomorrow......please pass the message along.......more details to follow.
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Juan S. Bonifacino @juanbonifacino.bsky.social · 29/01/2026
Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is required—together with cargo—for membrane recruitment. rdcu.be/e1ozM
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Juan S. Bonifacino @juanbonifacino.bsky.social · 29/01/2026
Highly recommend! Great mentor and environment.
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Juan S. Bonifacino @juanbonifacino.bsky.social · 29/12/2025
Our wonderful technician Xiaolin (Lin) Zhu is retiring after 27 years of dedicated service in our lab. We will miss her greatly, but we are happy for her as she begins this well-deserved new chapter in her life.
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Oded Rechavi @odedrechavi.bsky.social · 28/12/2025
"It's my turn to use the microscope"
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Juan S. Bonifacino @juanbonifacino.bsky.social · 26/12/2025
This year I had the chance to see Edvard Munch’s The Sick Child painting in Oslo. It’s a powerful reminder of what our Institute, NICHD, NIH, works to prevent and cure.
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Justin Taraska @taraska.bsky.social · 22/12/2025
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
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Juan S. Bonifacino @juanbonifacino.bsky.social · 23/12/2025
Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...
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Juan S. Bonifacino @juanbonifacino.bsky.social · 01/12/2025
Interesting findings linking RAB14 to the EARP complex and the lipid transfer proteins SHIP164 and UHRF1BP1 on endosomes!
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Nicole Simmons @nicolesimmonsart.bsky.social · 17/11/2025
Painted tonight, but it’s nowhere near done, so instead here’s a piece I did in 2024 called Frosty Twilight (16”x20” mixed media). I went through a whole birches phase and this was part of that series. Anyhoooo….who’s ready for Monday?! I’m not! Lol #art #painting #mixedmedia #sundayscaries
Birch painting from 2024 that I thought turned out super cool
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Yousuf A. Khan @yousufakhan.bsky.social · 24/10/2025
This paper was a tour de force and would not be possible without he help of so many collaborators like @juanbonifacino.bsky.social and many more. Thank you!!!
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Yousuf A. Khan @yousufakhan.bsky.social · 24/10/2025
Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago
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Juan S. Bonifacino @juanbonifacino.bsky.social · 08/10/2025
Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...
academic.oup.com
EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects
Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling
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Juan S. Bonifacino @juanbonifacino.bsky.social · 21/09/2025
Big thanks to Amelia Glazier and @jcellsci.bsky.social for including me in ‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science journals.biologists.com/jcs/article/... Happy to be in such great company!
journals.biologists.com
‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science
Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.
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Juan S. Bonifacino @juanbonifacino.bsky.social · 21/09/2025
Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social‬ for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn
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Cell Chemical Biology @cp-cellchembiol.bsky.social · 19/09/2025
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics dlvr.it/TN9mpn
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Pedro Rocha @pedroprocha.bsky.social · 08/09/2025
🚨🚨🚨 Please repost We are looking for postdocs to join our lab at NIH. Apply: www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply Learn more about training at NIH : www.training.nih.gov/research-tra...
Job add showing the lab logo and the following text: 
WHAT WE OFFER
Fully-funded fellowships up to five years  Opportunity to start your own research program or lead ongoing projects.
Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. 

Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC
Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville.
 
WHO YOU ARE
You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.
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Juan S. Bonifacino @juanbonifacino.bsky.social · 26/08/2025
Excited to share our new review with @depaceraffa.bsky.social‬, @saikat2025.bsky.social‬, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...
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Juan S. Bonifacino @juanbonifacino.bsky.social · 25/08/2025
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
rdcu.be
CHIP protects lysosomes from CLN4 mutant-induced membrane damage
Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...
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Juan S. Bonifacino @juanbonifacino.bsky.social · 24/08/2025
New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social ‬and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...
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Juan S. Bonifacino @juanbonifacino.bsky.social · 21/08/2025
👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
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Dr. Tara L. Conley @taralconley.com · 21/07/2025
me, every work week battling with the cloud.
photo of hank hill during the episode when he was at the dmv talking to a representative with a completely unrelated capture that reads:

I do not want to save to one drive. I want to save to the documents folder… On my computer… That I own… In my house.
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Razvan Borza @rborza.bsky.social · 23/11/2024
🚨 If you haven’t seen it yet… 📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition. Check it out at bioart.niaid.nih.gov
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Juan S. Bonifacino @juanbonifacino.bsky.social · 29/06/2025
Nice to meet @manorlaboratory.bsky.social in Canada and learn of his work on label-free imaging!
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Juan S. Bonifacino @juanbonifacino.bsky.social · 29/04/2025
Happy to have made a minor contribution to this exciting study by Tasha Morrison, John O’Shea, and colleagues highlighting the key role of glycosphingolipid metabolism in natural killer and CD8⁺ T cell biology. authors.elsevier.com/c/1l0F9_278y...
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Anirban Banerjee @banirbn.bsky.social · 08/04/2025
Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks ! Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters. bit.ly/42jWXYD. /n
tinyurl.com
Anirban Banerjee Lab: Section on Structural and Chemical Biology
The cell membrane is a uniquely complex and dynamic chemical environment. Even a simplistic binary description of an individual lipid molecule as hydrophobic tail and hydrophilic headgroup segments ma...
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Carlos Guardia @charlyguardia.bsky.social · 16/04/2025
Job ad is here! Check it out :)
training.nih.gov
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Juan S. Bonifacino @juanbonifacino.bsky.social · 13/04/2025
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to juan.bonifacino@nih.gov. Please share and repost!
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Traffic @traffic-journal.bsky.social · 19/03/2025
just published onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O‐Glycosylation
Cartoon illustrating defects caused by GARP dysfunction. (Left) Control cells exhibit normal Golgi morphology with a stratified distribution of enzymes and trafficking machinery. (Right) Following ac...
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Reposted by Juan S. Bonifacino
The Freeman Lab @spencerfreeman.bsky.social · 27/02/2025
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 12/12/2024
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos. Read more about the role here: www.nature.com/naturecareer... Apply by 30 DEC #ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
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Juan S. Bonifacino @juanbonifacino.bsky.social · 28/12/2024
RIP my fellow "porteña" Olivia Hussey. "Born on April 17, 1951, in Buenos Aires, Olivia lived a life full of passion, love, and dedication to the arts, spirituality, and kindness towards animals." www.cnn.com/2024/12/27/e...
cnn.com
‘Romeo And Juliet’ star Olivia Hussey Eisley dies at 73 | CNN
Olivia Hussey Eisley, star of the 1968 film “Romeo and Juliet” and the slasher classic “Black Christmas,” has died, according to a post on her Instagram page. She was 73.
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