Mutations in VPS13 proteins are associated with neurodegenerative conditions like Parkinson’s disease. New findings could point to therapeutic avenues.

A picture is worth 1,000 words, and this holds true for the plethora of information researchers can obtain from pictures of our cells. The constant processes

Increased activity of leucine-rich repeat kinase 2 (LRRK2) is an important risk factor for Parkinson’s disease. LRRK2 localizes to lysosomal membranes, and changes in lysosome physiology are emerging ...

Professor Taekjip Ha is a world-renowned biophysicist whose pioneering work in single-molecule fluorescence and force spectroscopy has transformed how

We are excited to share that Dr. Phyllis Hanson, a former postdoctoral fellow in Yale’s Cell Biology Department, was recently awarded the 2026 Sir Bernard Katz

VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...

FocalPlane features... membrane trafficking - News

In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...

imageimageLysosomes can be damaged by diverse cellular stresses, triggering cellular responses that repair or remove them. This manuscript shows that BLTP3A, a Rab7 effector, is first shed from lysoso...

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U.S. Immigration and Customs Enforcement (ICE) and the Department of Homeland Security (DHS) have published a notice in the Federal Register proposing changes to regulations that would significantly s...

Dai et al. report the localization of BLTP2 in different human cell types and reveal binding partners that mediate its tethering to the PM and to PM-connec

Naughton et al. establish that the ER experiences forces in the piconewton range across the ER lumen and identify NOMO as a force-bearing transmembrane pro