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Simon Bayly

@simonbayly.bsky.social
1.5K followers 864 following 2.1K posts

Reformed chemist 👨‍🔬 IP licensing and spinouts at the Francis Crick Institute. Also post about cycling 🚲 Opinion my own etc.

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Simon Bayly @simonbayly.bsky.social · 11h
ALT text: “a blue globular protein remains oblivious as a strand of beige spaghetti nonchalantly caresses its left extremities“
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The Francis Crick Institute @crick.ac.uk · 29/09/2026
We're looking for undergraduate students at UK universities who are interested in scientific research to join one of our labs or facilities for 12 months as part of our sandwich student programme. Apply by 6 October: www.crick.ac.uk/careers-and-study/s…
crick.ac.uk
Sandwich students
Sandwich students join one of the Crick’s research groups or science technology platforms for 12 months to work on a research project.
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Simon Bayly @simonbayly.bsky.social · 29/09/2026
In plasma there are median 11 proteoforms per protein! 🤯https://www.biorxiv.org/content/10.64898/2026.09.26.754256v1
biorxiv.org
A draft atlas of the human plasma proteome at isoform resolution
Key plasma protein, including albumin, complement system proteins, and coagulation factors circulate in biochemically and functionally distinct isoforms, or proteoforms. Despite the importance of thes...
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Simon Bayly @simonbayly.bsky.social · 29/09/2026
Hmm, I have no clue how this patchy narrative is going to be turned into policy
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Katie Martin @katie0martin.ft.com · 29/09/2026
Either this is true, in which case *what are we doing here*? Shut it down. Or it's bullshit, in which case these are truly silly people unworthy of our money
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Simon Bayly @simonbayly.bsky.social · 28/09/2026
This was another wild race. Did MVDP go too early? Was Del Toro working for McNulty? Would Pog just have blown them all away? #cycling
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Simon Bayly @simonbayly.bsky.social · 28/09/2026
This was another wild race. Did MVDP go too early? Was Del Toro working for McNulty? Would Pog just have blown them all away? #cycling
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Carl Zimmer @carlzimmer.com · 27/09/2026
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
nyti.ms
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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Simon Bayly @simonbayly.bsky.social · 26/09/2026
This was a phenomenal race
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Caroline Bartman @cbartman.bsky.social · 25/09/2026
Ok what is the most death metal biology term? Cytokine storm? Programmed death 1? Executioner caspase? Other?
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Simon Bayly @simonbayly.bsky.social · 24/09/2026
Biggest surprise I can remember was Tanaka and Fenn for electrospray MS. Most overlooked who still hasn’t won is Marvin Caruthers for phosphoamidite DNA synthesis
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Simon Bayly @simonbayly.bsky.social · 24/09/2026
New funds for UK life science venture firm www.british-business-bank.co.uk/news-and-eve... #biotech
british-business-bank.co.uk
Press release - 24 September, 2026 | British Business Bank
British Business Bank agrees to commit up to £135m to two new Advent Life Sciences funds
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The Francis Crick Institute @crick.ac.uk · 24/09/2026
Our next Medicine at the Crick event on 19 November explores 'not-so-acute' infections: viruses and bacteria that can persist in the body long after infection. Book online and in-person tickets ➡️ www.eventbrite.co.uk/e/medicine-a...
A person presents at a podium in front of an audience in an auditorium.
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Simon Bayly @simonbayly.bsky.social · 22/09/2026
174 km solo!
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Elodie Carmen Leroy @ecleroy.bsky.social · 21/09/2026
How can a single antibiotic halt translation across all domains of life? 🧬 Our new study in Nucleic Acids Research reveals how Sparsomycin traps active ribosomes through a conserved mechanism. academic.oup.com/nar/article/... #Ribosome #Translation #StructuralBiology #Antibiotics #RNA #iTPseq
Graphical representation of the T. thermophilus 70S ribosome showing the 30S and 50S subunits, mRNA, and P-site tRNA. Sparsomycin (yellow) binds in the peptidyl transferase center at the interface between the A and P sites. The enlarged view shows sparsomycin occupying the A-site cleft adjacent to the P-site fMet-tRNA, closely contacting its 3′ CCA end (C74, C75 and A76) and the attached fMet.
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Simon Bayly @simonbayly.bsky.social · 22/09/2026
"Share of revenue" = tax. And barely a squeak from the pharma companies. endpoints.news/pfizer-lilly...
endpoints.news
Pfizer, Lilly 'most favored nation' deals to give US share of revenue from raised foreign prices
Pfizer and Lilly's MFN contracts with HHS show the drugmakers agreed to share revenue from higher overseas prices with the government.
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
ALT text “pink protein slides towards and then aggressively hugs smaller teal protein”
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
RNA clumps together if you don't design it correctly www.pnas.org/doi/10.1073/...
pnas.org
Maintaining transcriptome solubility constrains mRNA sequence composition | PNAS
RNA is built from a four-nucleotide alphabet. Complementary sequences inevitably arise, creating pervasive opportunities for promiscuous RNA–RNA in...
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
The (Steric) Clash #chemsky #chemcaht
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
ALT text “pink protein slides towards and then aggressively hugs smaller teal protein”
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Simon Bayly @simonbayly.bsky.social · 19/09/2026
Very enjoyable (and very long) thread. Who knew there were so many restaurant related faux pas!
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Simon Bayly @simonbayly.bsky.social · 19/09/2026
I’m in two minds about this…
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Simon Bayly @simonbayly.bsky.social · 18/09/2026
Pardon me?
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Simon Bayly @simonbayly.bsky.social · 16/09/2026
MARSH GIBBON THREATENS ANNEXATION!
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Simon Bayly @simonbayly.bsky.social · 14/09/2026
Interested in the state of the art of AI in biology? @crick.ac.uk is hosting a seminar series www.eventbrite.co.uk/e/ai-in-biol...
eventbrite.co.uk
AI in Biology Seminar | Professor Caroline Uhler
A new AI for Biological Discovery Seminar Series, presented by the Francis Crick Institute.
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Philip Ball @philipcball.bsky.social · 11/09/2026
I am rather delighted by this paper. So here’s a thread to tell you why, and why it matters. /1 www.science.org/doi/10.1126/...
science.org
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely unknown. By using live imaging, we reveal that the ...
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Simon Bayly @simonbayly.bsky.social · 11/09/2026
These archea don't do binary fission, they spawn!
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Michael O’Neill @michaeloneill.org · 03/06/2026
Not being dramatic, but this probably signals the effective end of Chemistry in English Universities. An *efficient* Department loses something like £2k per Chemistry student per year; this change will roughly double that loss. Universities would be mad to keep teaching Chemistry.
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Kranzusch Lab @kranzuschlab.bsky.social · 10/09/2026
Stunning cryo-ET analysis from the Harrison Lab capturing every stage of how non-membrane viruses infect animal cells www.science.org/doi/10.1126/...
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Simon Bayly @simonbayly.bsky.social · 10/09/2026
He makes a phenomenal team with Wout Van Aert #cycling
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Simon Bayly @simonbayly.bsky.social · 08/09/2026
Big new release from DeepMind - this time it's in silico mutagenesis of the entire human genome! www.nature.com/articles/d41...
nature.com
DeepMind’s new genome ‘atlas’ charts effects of all 9 billion human gene mutations
AI model AlphaGenome forecasts the consequences of altering every single DNA letter in the human genome.
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Henry Mance @henrymance.ft.com · 08/09/2026
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
Nice list of 'conjectures' for bioengineers to solve www.linkedin.com/pulse/strang... #biotech
linkedin.com
Strange and Marvelous Challenges for Biological AI
The best conjectures are written in the margins. In 1637, Pierre de Fermat set the most iconic intellectual thirst trap in the history of mathematics when he scribbled a note in his copy Diophantus’s ...
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
Know a postdoc, first-time founder or academic thinking about starting a company? Fantastic (and free) life science entrepreneurship programme offering practical leadership training from CEOs and industry experts. Delivered by @crick.ac.uk and @bia-uk.bsky.social lnkd.in/exF-8Gyi #biotech
bioindustry.org
PULSE
Programme for up-and-coming life sciences entrepreneurs. Apply by 17 January 2027.
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
Is this a case of CRO businesses not being able to achieve venture scale exits and hence having to pivot to drug development? endpoints.news/thiel-backed... #biotech
endpoints.news
Thiel-backed Lindus pivots to hunting external drug assets after CRO-arm sale
Lindus Therapeutics sheds its CRO business, rebrands from Lindus Health and pivots to in-licensing external drug assets, CEO Meri Beckwith says.
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Research Professional News @resprofnews.bsky.social · 07/09/2026
Breaking: Aria chair to stand down following conflict of interest criticism. Matt Clifford will step aside so new Anthropic role “doesn’t become a distraction”. www.researchprofessionalnews.com/rr-news-uk-i...
researchprofessionalnews.com
Aria chair to stand down following conflict of interest criticism - Research Professional News
Matt Clifford will step aside so new Anthropic role “doesn’t become a distraction”
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
Know a postdoc, first-time founder or academic thinking about starting a company? Fantastic (and free) life science entrepreneurship programme offering practical leadership training from CEOs and industry experts. Delivered by @crick.ac.uk and @bia-uk.bsky.social lnkd.in/exF-8Gyi #biotech
bioindustry.org
PULSE
Programme for up-and-coming life sciences entrepreneurs. Apply by 17 January 2027.
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
New 'Northern Scale-up Fund' backed by £150M from BBB. thenextleap.is/news/north-e...
thenextleap.is
Spinouts in the north of England to benefit from £150m scale-up fund
The fund will make investments in university spinouts ranging from £5 million to £15 million.
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
Nice list of 'conjectures' for bioengineers to solve www.linkedin.com/pulse/strang... #biotech
linkedin.com
Strange and Marvelous Challenges for Biological AI
The best conjectures are written in the margins. In 1637, Pierre de Fermat set the most iconic intellectual thirst trap in the history of mathematics when he scribbled a note in his copy Diophantus’s ...
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
Is this a case of CRO businesses not being able to achieve venture scale exits and hence having to pivot to drug development? endpoints.news/thiel-backed... #biotech
endpoints.news
Thiel-backed Lindus pivots to hunting external drug assets after CRO-arm sale
Lindus Therapeutics sheds its CRO business, rebrands from Lindus Health and pivots to in-licensing external drug assets, CEO Meri Beckwith says.
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Simon Bayly @simonbayly.bsky.social · 07/09/2026
BBC Radio 4 Today programme is an embarassment. Caught a segment this morning where a chap from the German CDU was patiently having to explain multiparty democracy to one of the presenters.
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Simon Bayly @simonbayly.bsky.social · 06/09/2026
Huh, this is curious!
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Jason Gavenonis @gavenonis.bsky.social · 04/09/2026
Saw this on the old site and had to share: www.generalatoms.com/RotorRoulette/ #chemsky #chemchat
A 24-well centrifuge rotor with 15 tubes. Of course it's balanced.
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Simon Bayly @simonbayly.bsky.social · 03/09/2026
Wow!
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David Miller @biotechmiller.bsky.social · 02/09/2026
I know history always repeats itself, but (for the olds on here like me) aren't all the conversations about the AI bubble straight up reruns of the 2000 B2B bubble?
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Annika Barber @annikabarber.bsky.social · 02/09/2026
Drosophila people - I *really* need to know the story behind the naming of the Turandot genes. I have backtracked to the 2001 papers from the Hultmark lab and there's no explanation! @hansonmark.bsky.social do you know?? Any other fly stress response peeps? Opera fans? 🪰
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Simon Bayly @simonbayly.bsky.social · 02/09/2026
Curious policy proposal relating to UK university #spinout companies www.thetimes.com/article/cadf...
thetimes.com
Ministers plot exit tax for university spinouts moving abroad
The proposed levy is intended to discourage UK-based companies that have benefited from taxpayer money taking valuable intellectual property and jobs overseas
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Simon Bayly @simonbayly.bsky.social · 02/09/2026
Event 29th Sept at the @crick.ac.uk www.eventbrite.co.uk/e/computatio...
eventbrite.co.uk
Computational Biology Symposium @ The Crick
One day symposium connecting London’s computational, AI and biotech communities to spark collaboration and accelerate discovery
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LeGruppetto @legruppetto.fr · 02/09/2026
Lewis Askey (NSN Cycling Team) triomphe sur la 1re étape du #TourofBritain ! Le Britannique (25 ans) signe son 1er succès de la saison après s'être montré le plus fort dans la dernière difficulté. Askey devance Filippo Ganna (Netcompany Ineos) et Tim Wellens (UAE Emirates-XRG).
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Simon Bayly @simonbayly.bsky.social · 01/09/2026
Where am I?
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