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Agrobacterium -mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, ...

Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, u...

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice

تعلن مؤسسة الكويت للتقدم العلمي (KFAS) أسماء الفائزين بجائزة الكويت في دورتها الرابعة والأربعين لعام 2025، والتي تمنحها المؤسسة سنويًا للعلماء الكويتيين والعرب ممن حققوا إنجازات بارزة ومساهمات علمية و...

Adding 850 square-feet to the back of the ranch home brings in sunlight and views of greenery.

Startups are providing tantalizing glimpses of AI-assisted antibody discovery and claiming game-changing potential, even as new models remain hidden and industry awaits full disclosure and benchmarkin...

How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), ...

Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...

Abstract. Heterochromatin formation in Schizosaccharomyces pombe requires the spreading of histone 3 (H3) Lysine 9 (K9) methylation (me) from nucleation ce

Use AIMBE's letter template below to send an email to your Members of Congress on issues that matter. We encourage you to edit and personalize the note, sharing your individual experience. Please note...

The construction and high-precision fitness profiling of a C. neoformans knockout library reveals a high-resolution functional map of its genome and allowed for the identification of fungal analogs of...

Defining the minimal genetic requirements for cellular life remains a fundamental question in biology. Genomic exploration continually reveals novel microbial lineages, often exhibiting extreme genome...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

How the administration is breaking the government, and what that means for all of us.

Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA synthetases for GCE, increasing...

Read an exclusive interview with Prof. Ngo covering his research, his history with the journal, and advice to early career researchers.

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...

Cell and gene therapies often rely on the expression of exogenous proteins derived from nonhuman organisms. An emerging consensus is to reduce the potential immunogenicity of such therapies by instead...

The Pulitzer Prize-winning science writer talks about burnout from covering the pandemic and how bird-watching gave him a new sense of hope.

Nature Chemical Biology - Engineering of a human-derived protease controlled exogenously by its FDA-approved inhibitor enables control over cytokine activity in cell-based therapies with reduced...

Nature Reviews Genetics - Recent genomic approaches are providing unprecedented opportunity to disentangle how genotype and environment affect organismal traits. The authors review the role of...

Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, w...

Artificial neural networks provide a powerful paradigm for nonbiological information processing. To understand whether similar principles could enable computation within living cells, we combined de n...

For Science!

Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.