Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.

The source data underlying results and figures in our manuscripts can be critical for assessing the rigour of our studies and for reproducibility. Ensuring the quality and provenance of these data dur...

Simulations integrating micro-C and imaging data provide a coherent view of chromatin organization from nucleosomes to clutches to domains, revealing that most regions form compact domains but short r...

A photolabile oligonucleotide system enables spatially resolved single-cell measurements to show how the epigenome regulates gene expression.

The Energy Technologies and Systems Division at Lawrence Berkeley National Laboratory is seeking a Postdoctoral Scholar to join the Jain...

A Nature investigation reveals a network of organizations that have been building their ranks through deceptive practices.

Physiological homeostasis is traditionally viewed as an individual process optimized through evolution to minimize the energetic costs of regulation. However, it remains unknown whether social proximi...

Tissue morphogenesis integrates developmental programs with cell mechanics, yet the mechanisms coupling these processes remain poorly understood. We investigated this link during neuroepithelial morph...

Recent changes in Genentech’s scientific organization, occurring as the company makes artificial intelligence (AI) increasingly central to its research strategy, highlight a broader question facing bi...

In a deterministic, non-chaotic system, the initial state fixes the future completely, yet that future may be impossible to forecast from it. Using a cellular automaton of communicating cells, this st...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

The citric acid cycle (TCA cycle) is the common terminal pathway for the oxidation of all nutrients. Citrate oxidation to oxaloacetate produces CO2, and citrate synthase (CS) uses nutrient-derived ace...

There is growing concern that AI can blunt memory and reasoning. But science shows ways to keep the brain sharp.

The fitness of an organism determines its likelihood of succeeding in short-term competition, but many other factors can influence its long-term success. In this study, we investigate the relative con...

Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.

We invite applications for a 2-year Postdoctoral Research Associate position in Nucleic Acid Computing and Molecular Programming in the laboratory of Dr Gamze Gursoy at the University of Cambridge. Th...

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudi...

We have developed a system that translates amino acid sequences into musical notes, reflecting the specific characteristics of those sequences. Unlike most other methods of converting amino acid sequences into musical compositions, our approach enables the same algorithm to be used for converting musical passages back into proteins without relying on their nucleotide sequence encoding. This is accomplished through the use of a doublet degenerate code to encode musical notes, chords, and pauses. As a result, one can select from several dozen options to create an amino acid sequence with specified properties.

The Institute of Biomedicine is involved in both research and education. In both of these

Abstract. Experimental evolution provides a powerful framework for dissecting how ecological interactions shape adaptive trajectories. Here, we evolved Kle

Prado, Malkani, et al. develop TRACKS, a biofabrication platform combining 3D-printed sacrificial templates with vascular self-assembly to pattern vessel networks in mouse organ-scale tissues. By arch...

ALT: Kid Cool

Only germ cells can give rise to a totipotent embryo, yet a conserved transcriptional program for germ cell identity remains elusive. Profiling Drosophila primordial germ cells (PGCs) across embryogen...