bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 14hDesigning enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 02/10/2026Heterologous engineering of receptors using OrthoRep (HERO) for directed evolution of GPCRs in yeast www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 02/10/2026An AI-powered cloud biofoundry for autonomous biological research www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 01/10/2026A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 01/10/2026Rational mRNA Structure -guided Attenuation Enables Embryo-safe in-ovo NDV Vaccination and Protection www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 30/09/2026Optimization of DNA Transformation in Mesoplasma florum and Identification of a Candidate Recipient Strain for Genome Transplantation www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 30/09/2026From Flocks to Swarms: Rewriting the Rules of Collective Cell Migration www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 29/09/2026Coupled enzyme discovery, evolution and synthetic yeast chassis adaptation for microbial biopolymer valorisation www.biorxiv.org/content/10.64898/20… 001
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 29/09/2026Multichromatic Dynamic Control of Multi-Membered Microbial Consortia Compositions for Chemical Production www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 28/09/2026PRIME: A modular plasmid-based platform for continuous in vivo evolution across bacteria www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 28/09/2026Reassessing the contribution of the histone H3 tail to KRAB-DNMT3L-mediated epigenetic silencing www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 28/09/2026Thermodynamic, Electrochemical and Practical Constraints on Electromicrobial Formate Assimilation www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 28/09/2026Coupling a developmental promoter to CRISPR interference for Wnt pathway regulation in human pluripotent stem cells www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 25/09/2026Gene expression noise is reduced in communicating synthetic cell populations www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 25/09/2026Boolean Logic-responsive FRET Biosensors via Genetically Encoded Autonomous Compilation www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 25/09/2026AI-Guided Multi-Objective Engineering of Glucoamylase Enables Acidification-Free Starch Saccharification www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 23/09/2026Constructing Virtual Viruses in A Spatial Minimal Cell www.biorxiv.org/content/10.64898/20… 001
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026Genetically inducible coordinators of cytokine signaling pathways for interrogating T cell motility www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026A Dynamically Regulated Designed IL-2 for Tumor-localized Signaling www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026Engineering Persistent and Rewritable Genetic Memory in Bacteria through Multiscale Plasmid Competition www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026Nanobody-Functionalized AAV achieves Promoter-independent Neuronal Targeting in the CNS www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026A step toward synthetic endosymbiosis: introducing Escherichia coli and the trypanosomatid endosymbiont Candidatus Kinetoplastibacterium crithidii into mammalian cells using a polyethylene glycol-based fusion protocol www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026Generative Neuromorphic Programming of Mammalian Cells www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026A Yeast Logic Toolkit for Fast and Efficient Assembly of Genetic Circuits www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid Tumors www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 22/09/2026BRIDGE: A broad-host platform for interkingdom DNA delivery enabling the genetic domestication of phylogenetically diverse yeasts www.biorxiv.org/content/10.64898/20… 021
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 19/09/2026The proteome as a whole: from a passive reflection of the transcriptome to an active cellular organizer www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 18/09/2026Firewalled synthetic commensal blocks horizontal gene transfer in the gut www.biorxiv.org/content/10.64898/20… 001
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 18/09/2026Characterization of a fungal mixed-linkage glucan synthase www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 18/09/2026Data-driven predictive design of engineered living hydrogels www.biorxiv.org/content/10.64898/20… 001
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 17/09/2026Programmable DNA Assemblies Reconstitute Supramolecular Protein Function www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 17/09/2026A methylome-guided toolkit for genetic engineering of the fast-growing cyanobacterium UTEX 3222 www.biorxiv.org/content/10.64898/20… 010
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 17/09/2026Dynamic expression range expansion of ECF sigma factor-dependent synthetic regulons by promoter context engineering www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 17/09/2026Universal donor plasmids for biallelic degron-tagging in mammalian cells and organoids www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 17/09/2026Attachment site, not linker length, bounds tethered base editor windows www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 17/09/2026Coupling cell growth to protein secretion enables pooled screening at single-cell resolution in bioreactors www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 16/09/2026Engineering phenotypic heterogeneity for functional organization in microbial populations www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 16/09/2026Carboxysome-Inspired Protein Coacervates for Light-Driven CO2 Reduction and H2 Evolution www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 11/09/2026Biocatalytic Production of Galantamine in Yeast through Cytochrome P450 Optimization www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 11/09/2026Full-length transcriptomics and proteomics reveal how genome minimization reshapes gene expression in synthetic bacteria www.biorxiv.org/content/10.64898/20… 011
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 10/09/2026Adaptive laboratory evolution of a yeast co-culture chassis for modular bioproduction www.biorxiv.org/content/10.64898/20… 031
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 10/09/2026Generative Language Modeling for Antibody CDR Grafting and Alignment-driven De Novo Design www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 10/09/2026Human ORFeome expression in S. cerevisiae to better understand extracellular vesicle biology www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 04/09/2026Programmable Self-Assembly of RNA Nanostructures with >100 Unique Components www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 03/09/2026Unbiased and scalable reduction of diverse bacterial genomes www.biorxiv.org/content/10.64898/20… 011
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 03/09/2026Living electronic transistors with tunable conductivity www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 03/09/2026Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 02/09/2026Uncertainty Quantification in Stochastic Dynamical Gene Regulatory Networks www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 01/09/2026Harnessing Escherichia coli motility to engineer bacterial Voronoi patterns www.biorxiv.org/content/10.64898/20… 000
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 01/09/2026Ratiometric growth-rate control enables robust coexistence in competing microbial consortia www.biorxiv.org/content/10.64898/20… 000
