Reposted by Roberto Zoncu Lab
The ESCRT machinery mediates repair of damaged lysosomal membranes. But how does it recognise damage? Authors @nature report LASER, a fast-forming protein assembly that detects Ca2+-leakage from sites of lysosomal injury and recruits ESCRTs there.
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LASER couples damage sensing to ESCRT assembly for lysosome repair - Nature
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
