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Eric Chevet

@ericchevet.bsky.social
2.8K followers 1.1K following 450 posts

ER_literature, endoplasmic reticulum, proteostasis, secretory pathway, cancer research and more PI @inserm oss-clcc.univ-rennes.fr

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Reposted by Eric Chevet
The Interactive Fly @interactivefly.bsky.social · 17h
Milano, S. N., Bayer, L. V., Ko, J. J., Casella, C. E., Bratu, D. P. (2025). The role of ER exit sites in maintaining P-body organization and integrity during Drosophila melanogaster oogenesis. EMBO Rep, 26(2):494-520 link.springer.com/article/10.1...
link.springer.com
The role of ER exit sites in maintaining P-body organization and integrity during Drosophila melanogaster oogenesis - EMBO Reports
Processing bodies (P-bodies) are cytoplasmic membrane-less organelles which host multiple mRNA processing events. While the fundamental principles of P-body organization are beginning to be elucidated...
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asofiahcosta.bsky.social @asofiahcosta.bsky.social · 27/09/2026
This week's issue of bims-metlip is here biomed.news/bims-metlip/.... It covers a wide array of computational and analytical methods for small molecule and lipid analysis. A collaboration with @biomednews.bsky.social. Enjoy!
static.klipy.com
Study Freak in the Library
ALT: Study Freak in the Library
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Korolchuk Lab @korolchuklab.bsky.social · 27/09/2026
#Autophagy and #mTOR papers from last week, enjoy! biomed.news/bims-auttor/...
static.klipy.com
Batman Thinking: Interesting...
ALT: Batman Thinking: Interesting...
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Eric Chevet @ericchevet.bsky.social · 27/09/2026
Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Protein entanglement misfolding in proteasomal degradation or near-native misfolded states persistence www.nature.com/articles/s41...
biomed.news
bims-proteo 2026-09-27 papers
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 25/09/2026
This thread keeps getting longer and more damning of the "winner" and its creator @healthcare.nikon.com is damaging heir brand by not intervening 🧪 @statnews.com Want to cover this?
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 24/09/2026
Phosphorylation-dependent interaction between VAP proteins and INF2 influences ER morphology: Current Biology www.cell.com/current-biol...
cell.com
Phosphorylation-dependent interaction between VAP proteins and INF2 influences ER morphology
Kage et al. report a novel phosphorylation-dependent interaction between INF2 and VAP proteins. Increased cytoplasmic calcium stimulates INF2 phosphorylation, which, in turn, allows VAP binding. The I...
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Reposted by Eric Chevet
Yuan He @yuanhejhu.bsky.social · 22/09/2026
A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.
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Olivier Bastien @bass42.bsky.social · 22/09/2026
☝️ Point Larousse Chantage nom masculin (de chanter) 1. Délit consistant à extorquer, à l'aide de menaces, des fonds, des valeurs, une signature d'un acte. 2. Action de brandir une menace pour obtenir de quelqu'un quelque chose qu'il refuse : Un chantage sentimental. 🤷 #Macron #Lecornu #ESR
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Guillaume Mas @masgu.bsky.social · 21/09/2026
New in @CommsBio: We discovered a tyrosine motif that creates a switch for J-domain proteins. Phosphorylation of this motif disrupts the fold, causing degradation or loss of Hsp70 activation. Congrats Raju, @annaleder.bsky.social , @chercheurjuteux.com & all coauthors www.nature.com/articles/s42...
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Reposted by Eric Chevet
Korolchuk Lab @korolchuklab.bsky.social · 20/09/2026
#Autophagy and #mTOR papers from the past two weeks, have a look, there’s some really cool stuff! biomed.news/bims-auttor/... biomed.news/bims-auttor/...
static.klipy.com
Kid Cool
ALT: Kid Cool
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Eric Chevet @ericchevet.bsky.social · 20/09/2026
Good morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Encoded and non-genetic protein variants expand human functional proteome www.nature.com/articles/s41...
biomed.news
bims-proteo 2026-09-20 papers
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Stella Hurtley @smhsci.bsky.social · 18/09/2026
Out now in @science.org Multi-organelle signatures map cell-state diversity and metabolic adaptation in tissues | Science www.science.org/doi/10.1126/...
science.org
Multi-organelle signatures map cell-state diversity and metabolic adaptation in tissues
Cell-state diversity drives tissue adaptability, repair, and disease resilience, but capturing this complexity is a challenge. Current approaches rely on transcriptional profiling and overlook organel...
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Reposted by Eric Chevet
Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 17/09/2026
“I worked in a lab with… limited financial resources. As a result, I learned to do science with little room for trial and error or designing endless experiments. Every experiment had to be carefully thought through so that it addressed the scientific question while remaining financially feasible.”
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Eric Chevet @ericchevet.bsky.social · 16/09/2026
www.biorxiv.org/content/10.6...
biorxiv.org
Atlas of Proteomic Technologies: an evidence-based framework for selecting and combining commercial proteomics platforms
High-throughput proteomics now spans several technologies that differ in biological breadth, precision, specificity, sensitivity, cost, and method(s) of quantification; however, investigators currentl...
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Eric Chevet @ericchevet.bsky.social · 16/09/2026
www.nature.com/articles/s41...
nature.com
Evolution and heterogeneity of lethal metastatic bladder cancer subtypes - Nature
A rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance in metastat...
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Reposted by Eric Chevet
Maja Radulovic @majarad.bsky.social · 15/09/2026
Our study on DFCP1 and lysosome membrane repair is live! We uncover a previously unrecognized role for omegasomes in the cellular response to lysosomal membrane damage, revealing another layer of regulation in how damaged lysosomes are repaired. www.nature.com/articles/s41...
nature.com
DFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell Biology
Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...
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Eric Chevet @ericchevet.bsky.social · 15/09/2026
www.medecinesciences.org/fr/articles/...
medecinesciences.org
Un cancer au cœur de la recherche contre le cancer : la menace grandissante des fabriques à articles scientifiques | médecine/sciences
médecine/sciences (M/S), revue internationale dans le domaine de la recherche biologique, médicale et en santé
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Reposted by Eric Chevet
Gavin McStay @gavinmcstay.bsky.social · 13/09/2026
You can subscribe to this report to receive weekly updates on this topic by going to biomed.news/bims-proteo
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Eric Chevet @ericchevet.bsky.social · 13/09/2026
Good morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Ribosome stalling position, spacing, and A-site occupancy impact translation and cotranslational mRNA decay in plants www.pnas.org/doi/10.1073/...
biomed.news
bims-proteo 2026-09-13 papers
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Sonya Neal @neal-lab.bsky.social · 11/09/2026
The Neal lab is hiring a postdoctoral fellow to lead exciting structural and biophysical studies of membrane protein quality control! Competitive HHMI-scale salary + cutting-edge science + a genuinely wonderful and supportive lab culture. Please share widely with anyone who might be interested!
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Eric Chevet @ericchevet.bsky.social · 08/09/2026
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion www.nature.com/articles/s41... a new role for CLIMP63!!!
nature.com
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion - Nature Communications
Whether annulate lamellae (AL) occur in normal somatic cells was an open question. Here, the authors demonstrate that AL drive nuclear pore complex assembly and nuclear expansion during G1, defining a...
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Reposted by Eric Chevet
Association Française de Science Politique @asso-afsp.bsky.social · 07/09/2026
#ESR Dans le cadre des Assises pour l’Université et pour la Recherche, une #enquête en ligne à destination des doctorant·es est lancée. Les résultats viendront directement nourrir le Livre blanc des Assises. Pour y répondre : framaforms.org/doctorantes-...
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Eric Chevet @ericchevet.bsky.social · 06/09/2026
Good morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: ArticleOnline nowSeptember 01, 2026 Ratiometric transcriptional activation by protein degradation www.cell.com/cell/abstrac...
biomed.news
bims-proteo 2026-09-06 papers
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Journal of Cell Biology @jcb.org · 05/09/2026
#Ceramide mediates cell-to-cell ER stress transmission by modulating #membrane fluidity. From Yazhen Huo, Likun Wang and colleagues (Institute of Biophysics, Beijing): rupress.org/jcb/article/... 📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti... #EMBOLipidCode
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Sonya Neal @neal-lab.bsky.social · 02/09/2026
Come be my colleague!! 🎉 We’re hiring an Assistant Professor in Developmental Biology at UCSD! If you’re doing exciting work in development or regeneration, come join us!! Please spread the word and apply! apol-recruit.ucsd.edu/JPF04591
apol-recruit.ucsd.edu
Assistant Professor of Developmental Biology
University of California, San Diego is hiring. Apply now!
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 01/09/2026
Ne nous leurrons pas, la disparition annoncée de l'IRD #ESR #veilleESR est un ballon d'essai afin de tester la résistance et la mobilisation de la communauté. Si ça passe crème, l'absorption/fusion des autres EPST, cette fois pas l'Université, va suivre.
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Eric Chevet @ericchevet.bsky.social · 31/08/2026
@inserm.fr @insermgrandouest.bsky.social @rennesuniv.bsky.social
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Mrs. Betty Bowers @mrsbettybowers.bsky.social · 30/08/2026
Ron and Cassie DeSantis: These two crooks stole $10 million from a settlement with a charity, wired it to Cassie’s fake “charity,” laundered it through two puppet organizations, and then used it for political ads in an election year. They should be in jail.
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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 30/08/2026
Can dual-targeting #UFMylation inhibitors defeat #Glioblastoma? Targeting the DDRGK1–UFL1 pathway with osimertinib or CP-24 suppresses UFMylation and ER-phagy, induces #ERstress and promotes antitumor M1 macrophage polarization. @tsinghuauniversity.bsky.social #OpenAccess: doi.org/10.1038/s413...
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Reposted by Eric Chevet
asofiahcosta.bsky.social @asofiahcosta.bsky.social · 30/08/2026
Just issued: Latest edition of bims-metlip, a weekly roundup of novel computational and analytical methods for metabolomics and lipidomics. In collaboration with @biomednews.bsky.social biomed.news/bims-metlip/...
static.klipy.com
Breaking News Geo News
ALT: Breaking News Geo News
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 30/08/2026
Here is our fresh selection of papers on #Mitochondria in #Health & #Disease from last week! biomed.news/bims-mitdis/... ➡️ LRRK2 impairs the release sites of Parkinsons disease vulnerable dopa axons @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
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Reposted by Eric Chevet
Korolchuk Lab @korolchuklab.bsky.social · 30/08/2026
#Autophagy and #mTOR papers from last week, selected with the help of @biomednews.bsky.social search engine, enjoy! biomed.news/bims-auttor/...
biomed.news
bims-auttor 2026-08-30 papers
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Gavin McStay @gavinmcstay.bsky.social · 30/08/2026
you can sign up to receive weekly updates on this report by going to biomed.news/bims-proteo
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Cell Reports @cp-cellreports.bsky.social · 30/08/2026
Phosphatidylserine synthesis tunes IP3R-mediated ER Ca2+ release via phospholipid homeostasis
dlvr.it
Phosphatidylserine synthesis tunes IP3R-mediated ER Ca2+ release via phospholipid homeostasis
Zhou et al. found that phosphatidylserine (PS) regulates ER Ca2+ homeostasis by modulating IP3R-mediated Ca2+ release. Manipulating phospholipid composition through the phospholipid-SREBP axis normalizes IP3R-mediated Ca2+ release during PS deficiency.
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Eric Chevet @ericchevet.bsky.social · 30/08/2026
Good morning! This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage state link.springer.com/article/10.1...
biomed.news
bims-proteo 2026-08-30 papers
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Denis Chrétien @dchretien.bsky.social · 28/08/2026
Dear #CryoEM and #Microtubule enthusiasts, I’m thrilled to have been part of this exciting journey: www.biorxiv.org/content/10.6... We discovered and characterized a manchette-like microtubule machinery in Xenopus spermatids, likely involved in sperm reshaping and membrane reorganization. (1/3)
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Eric Chevet @ericchevet.bsky.social · 28/08/2026
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease | Science www.science.org/doi/10.1126/...
science.org
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to cor...
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Reposted by Eric Chevet
Valérie Masson-Delmotte @valmasdel.bsky.social · 27/08/2026
L'article complet est disponible ici, www.sciencedirect.com/science/arti... 5/...
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Valérie Masson-Delmotte @valmasdel.bsky.social · 27/08/2026
La catastrophe au Népal a été induite par un effondrement de glacier du Langtang Lirung, à une altitude d'environ 5200 mètres. Que sait-on du lien avec le réchauffement climatique dû aux activités humaines pour les glaciers de ce secteur ? 1/...
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Julien Gossa @juliengossa.cpesr.fr · 27/08/2026
[ #VeilleESR #LPPR ] La France dans la compétition scientifique mondiale : radioscopie d'un décrochage ? - Rapport OST / @hceres.bsky.social « la régression de la position française s’observe dès les années 2013/2014, et est de l’ordre de 50% à 60% selon les indicateurs en une dizaine d’années »
hceres.fr
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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 27/08/2026
Valérie Masson-Delmotte: Comment agir enfin pour le climat? Toujours aussi pertinente @valmasdel.bsky.social www.rts.ch/info/environ...
rts.ch
Climat : comment agir enfin, selon Valérie Masson-Delmotte
Incendies dévastateurs, canicules à répétitions, sécheresse… l’été 2026 est la démonstration claire d’un climat qui se dérègle, et de ses ravages. Comment se mettre vraiment en action pour changer la ...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 26/08/2026
Pro tip: Most of these @dshb-antibodies.bsky.social Abs are documented in dozens of publications and are also substantially cheaper.
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Maxim Greenberg @maxvcg.bsky.social · 26/08/2026
We always knew you couldn't trust these antibody data sheets, but the extent to which it is essentially industry practice to manipulate data is truly shocking
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Flo Débarre @flodebarre.eurosky.social · 25/08/2026
In a new blog post, I revisit a claim made by Steven Quay, rumored to be the next NIAID director: that "Genome sequence archives" for SARS-CoV-2 sequences from patients at an Army hospital "were created on December 10, 2019". This was not the case ▫️1/🧵 #covidorigin pandemonium.hypotheses.org/1938
pandemonium.hypotheses.org
Did the European Nucleotide Archive receive SARS-CoV-2 sequences from Wuhan as early as 10 December 2019?
(TL;DR: No.) Some lab leakers claimed that SARS-CoV-2 sequences had been submitted to the ENA online repository on 10 Dec 2019, several days before the first known submitted sequence, and also even be...
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Eric Chevet @ericchevet.bsky.social · 25/08/2026
www.lecanardenchaine.fr/politique/54...
lecanardenchaine.fr
Fonds publics : Un député RN joue à cash-cash avec ses assistants parlementaires | Le Canard enchaîné
Fausse facturation, arrangements familiaux, rémunérations occultes et en liquide… Elu de l'Aisne, José Beaurain collectionne les collaborateurs parlementaires.……
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Reposted by Eric Chevet
Inserm @inserm.fr · 25/08/2026
Une nouvelle étude Inserm suggère une association entre une exposition élevée et persistante à des niveaux élevés de bruit routier au début de l’enfance (jusqu’à 5 ans et demi) et des niveaux plus élevés de difficultés émotionnelles et relationnelles à l’âge de 10 ans. Lire le communiqué :
presse.inserm.fr
Une exposition élevée et persistante au bruit routier au début de l’enfance est associée à un risque accru de difficultés émotionnelles et relationnelles à 10 ans - Salle de presse de l'Inserm
En Europe, plus d’une personne sur cinq est exposée de manière chronique à des niveaux de bruit liés au transport considérés comme nocifs pour la santé; le trafic routier en constitue la principale so...
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Paul Gardner @ppgardne.bsky.social · 25/08/2026
It's increasingly apparent that lncRNAs have been over-called. It'll take a lot of hard graft to clear these annotations out: doi.org/10.1038/s414...
doi.org
LncRNA-LncDACH1 mediated phenotypic switching of smooth muscle cells during neointimal hyperplasia in male arteriovenous fistulas - Nature Communications
Arteriovenous fistulas are the most common vascular access points for hemodialysis, but they have a high incidence of postoperative dysfunction, mainly due to excessive neointimal hyperplasia. Here, t...
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Reposted by Eric Chevet
Julien Gossa @juliengossa.cpesr.fr · 25/08/2026
[ #VeilleESR #VeilleEN ] Les enseignants accueillent chaque réforme comme un nouveau dispositif périssable, et peinent de plus en plus à s’investir dans son déploiement. par @eleapommiers.bsky.social et @valentinregnault.bsky.social pour @lemonde.fr
lemonde.fr
A l’éducation nationale, la valse des réformes vue à travers vingt-cinq ans d’évolution permanente du code de l’éducation
« Le Monde » a analysé les modifications de ce corpus qui charpente le système scolaire français depuis sa création, en 2000. Le nombre et le rythme des remaniements confirment l’empilement des réform...
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Guillaume Limousin @sonicurticant.bsky.social · 25/08/2026
Comment un tel torchon a-t-il pu passer la barrière du reviewing ? C'est juste dingue. Il y a des méthododologies standardisées pour faire des méta-analyses propres. Et elles ont justement été conçues pour contrer les lobbys industriels.🔽
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Moonnz @moonzray.bsky.social · 23/08/2026
La désinformation tue.
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