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Niek van Hilten

@nvhilten.bsky.social
83 followers 82 following 53 posts

Postdoc in Michael Grabe's lab at University of California, San Francisco. 🌉 Trying to make sense of bouncing molecules. Biophysics / MD simulation / membrane proteins (I also love cycling and running!) 🚵🏼🏃🏼

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Reposted by Niek van Hilten
Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Niek van Hilten @nvhilten.bsky.social · 07/09/2026
New #lipidtime paper out in @biophysj.bsky.social! 🚨 We built "pseudoproteins" of different lengths to investigate protein-induced lipid sorting based on tail unsaturation. TLDR: - Unsaturated lipids ❤️ short proteins - Saturated lipids ❤️ long proteins (but not always) doi.org/10.1016/j.bp...
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Reposted by Niek van Hilten
Robert Arkowitz @robertarkowitz.bsky.social · 18/08/2026
www.pnas.org/post/journal...
pnas.org
Probes show lipids are far more selective for proteins than once thought
Lipids, according to recent findings, are not just diffusing randomly around the lipid bilayer (shown here), but actually have specific proteins they like to pair with. Image credit: Science Source/K...
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Reposted by Niek van Hilten
COINTREAUPRO @strings.bsky.social · 01/08/2026
So… they’re working
Atlanta says these bike barriers are protecting cyclists. Drivers keep crashing into them.
AJE
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Niek van Hilten @nvhilten.bsky.social · 31/07/2026
How exciting to get an email that starts with "We are pleased to inform you that..."!!! 🥳 I am grateful to receive two years of research funding from the American Heart Association to unravel the intricacies of phospholipid scrambling by TMEM16F that plays an important role in blood clotting.🩸
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Reposted by Niek van Hilten
André Nadler @nadlerlab.bsky.social · 29/07/2026
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
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Niek van Hilten @nvhilten.bsky.social · 08/07/2026
"I heard you like AI. So I applied an AI to rewrite my AI-generated manuscript about my new AI model to make it sounds less AI." 🤦
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Niek van Hilten @nvhilten.bsky.social · 04/07/2026
Had the privilege to attend the 75th Lindau Nobel Laureate Meetings this week. So grateful for UC sending me 🙏🏼 Met so many inspiring people, young scientist and Nobel laureates alike! Danke Danke Danke #LINO75
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Reposted by Niek van Hilten
Markus Deserno @markusdeserno.bsky.social · 23/06/2026
📣 Hear! Hear! 🦋 Behold this Bluetorial on a cool paper written with my PhD student Nathaniel Wesnak 🧪 If you want to dive into the rabbit hole of lipid flop-flop and its description as a stochastic process—here’s your TEASER TRAILER on some flippin’ awesome work: doi.org/10.1063/5.03... 1/26
doi.org
Stochastic process description of lipid flip-flop
Since lipid bilayers are self-assembled macroscopic aggregates, their constituent lipid molecules can spontaneously transition between the two leaflets. This so
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Niek van Hilten @nvhilten.bsky.social · 25/02/2026
Cool paper alert 🚨! Congrats @olzmannlab.bsky.social! Proud to have made a small contribution to this. One of the prettiest membrane-protein structures I have simulated ☺️
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Reposted by Niek van Hilten
tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026
Our paper on The Lipid Interactome is now published, and the database is open: lipidinteractome.org @ohsummi.bsky.social @ohsunews.bsky.social @nadlerlab.bsky.social @jeremybaskin.bsky.social Please RT to spread the word. doi.org/10.1093/bioi...
doi.org
The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions
AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon
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Niek van Hilten @nvhilten.bsky.social · 22/02/2026
Poster is up! Come chat at poster B198 if you wanna learn about MD simulations of TMEM16 lipid scramblases 🤓 #bps2026
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Niek van Hilten @nvhilten.bsky.social · 21/02/2026
Aptly decorated floor at the Membrane Structure and Function subgroup session ❤️ #bps2026
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Niek van Hilten @nvhilten.bsky.social · 21/02/2026
Let’s go!! #bps2026
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Niek van Hilten @nvhilten.bsky.social · 18/12/2025
As a martini simulator, lipid enthusiast, and map nerd, I absolutely love this one! 🌎
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Reposted by Niek van Hilten
Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
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Niek van Hilten @nvhilten.bsky.social · 30/10/2025
May lipid scramblases be selective after all?! New @pnas.org paper showing that TMEM16F prefers PS and PC over PE in the complex context of a real plasma membrane. www.pnas.org/doi/10.1073/...
pnas.org
A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane | PNAS
The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphati...
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Niek van Hilten @nvhilten.bsky.social · 20/10/2025
Evo-MD strikes again! Unraveling the physics of cholesterol attraction by transmembrane proteins. @natcomms.nature.com www.nature.com/articles/s41...
nature.com
Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction - Nature Communications
Cholesterol plays a key role in membrane biology. Here, authors employ evolutionary molecular dynamics simulations to explore interactions driven by linear protein sequences, challenging the predictiv...
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Niek van Hilten @nvhilten.bsky.social · 16/10/2025
🤯
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Reposted by Niek van Hilten
Vanni Lab at UNIFR, Switzerland @labvanni.bsky.social · 13/10/2025
Thanks to @snsf.ch, we are hiring two PhD students to investigate frontier topics in lipid biology using a combination of MD simulations and experiments. Preferred starting date: ASAP. Fribourg - and Switzerland - are quite nice, for both work and private life! Please spread the word!
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Niek van Hilten @nvhilten.bsky.social · 18/09/2025
Now published as a "version of record" at @elife.bsky.social elifesciences.org/articles/105...
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André Nadler @nadlerlab.bsky.social · 21/08/2025
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
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Niek van Hilten @nvhilten.bsky.social · 23/03/2025
Looking forward to this one!
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Reposted by Niek van Hilten
André Nadler @nadlerlab.bsky.social · 10/03/2025
Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow. www.biorxiv.org/content/10.1...
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Niek van Hilten @nvhilten.bsky.social · 20/02/2025
Wrapped up #BPS2025 with a scenic bike ride to Griffith observatory. This week was a blast! See you next year in SF 🌁 @biophysicalsoc.bsky.social
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Niek van Hilten @nvhilten.bsky.social · 17/02/2025
So much cool science at #bps2025! I’ll present my work on designing lipid scramblases tomorrow at 11 am.
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Niek van Hilten @nvhilten.bsky.social · 15/02/2025
✅ Arrived in #LA ✅ Funded 20 bicycles for World Bicycle Relief Now refocus on some awesome science at #bps2025 @biophysicalsoc.bsky.social I will keep the fundraiser open for another week, so donations are still welcome 🙏🏼
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Niek van Hilten @nvhilten.bsky.social · 13/02/2025
Day 4 ✅ Tough day of riding in the rain. Happy to take a rest day tomorrow. #santabarbara has awesome #bike infrastructure! Donations 🙏🏼 www.powerofbicycles.org/fundraisers/niekvanhilten
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Niek van Hilten @nvhilten.bsky.social · 12/02/2025
Day 3 ✅ Making the most of the sunny weather. Getting closer to LA and #bps2025! Donations 🙏🏼: www.powerofbicycles.org/fundraisers/...
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Niek van Hilten @nvhilten.bsky.social · 11/02/2025
Day 2 ✅ Getting closer to #bps2025 with every pedal stroke. Donations to World Bicycle Relief ➡️ www.powerofbicycles.org/fundraisers/...
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Niek van Hilten @nvhilten.bsky.social · 10/02/2025
On my way to #bps2025 @biophysicalsoc.bsky.social I’m biking from SF to LA to promote low-emission transportation and raise money for World Bicycle Relief. Donations: 🙏🏼 www.powerofbicycles.org/fundraisers/niekvanhilten
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Niek van Hilten @nvhilten.bsky.social · 03/02/2025
Our paper is now out in @elife.bsky.social! We performed @cg-martini.bsky.social MD simulations to capture >700 lipid scrambling events in 27 TMEM16 structures to systematically study their lipid scrambling rates and mechanisms. 📃 doi.org/10.7554/eLife.105111.1
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Niek van Hilten @nvhilten.bsky.social · 21/01/2025
From 9 to 14 February 2025, I embark on a 550 mile (900 km) bike adventure from San Francisco to Los Angeles to attend the annual BPS meeting @biophysicalsoc.bsky.social. On this trip, I strive to (1) raise money for World Bicycle Relief, and (2), to promote low-emission travel. A thread 🧵:
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