The nutrient-sensing kinase complex mTORC1 regulates metabolism, yet the physiological signals controlling its activity in the liver are incompletely defined. Here, the authors show that dietary prote...

WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...

SAN DIEGO – The American Association for Cancer Research (AACR) today announced the recipients of the AACR Trailblazer Cancer Research Grants during the Opening Ceremony of the AACR Annual Meeting 202...

Nutrition; Physiology; Cancer

Maria Perez-Matos’s research suggests that aging isn’t determined solely by genes or environment. Subtle molecular differences can influence how long and how well an organism lives. Understanding thes...

Peng Gao studies the “exposome”—the measure of an individual’s total environmental exposures over the course of their life and how those exposures impact biology and health.

Molecular physiology; Cell biology

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Though Tcf7l2 harbors the strongest genetic association with diabetes identified thus far, how it promotes metabolic disease remains unclear. Our aim …

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

We ask researchers to send us their stories of what they were working on when their research grant was cut. Today, we share the stories of Tashara and Brendan.

Cormerais et al. describe the TSC2-5A mouse model lacking the five phosphorylation sites on TSC2 through which AKT activates mTORC1. The TSC2-5A mice are developmentally normal but show reduced body- ...

For Brendan Manning, PhD, today’s advances in basic science are the stepping stones to the next breakthrough in treating tuberous sclerosis complex (TSC). Manning has spent the last 25 years researchi...

A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard C...

Mammalian tissues feed on nutrients in the blood circulation. At the organism level, mammalian energy metabolism is comprised of the oxidation, storag…

An approach to collect lymph drained from the primary tumor in mice enables the downstream characterization of the samples using metabolomics, lipidomics and flow cytometry.