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Nils Hebach

@nilshebach.bsky.social
440 followers 574 following 6 posts

Postdoctoral Researcher in the Swanton Lab, Francis Crick Institute, previously doctoral student in the Winkler Lab at DKFZ, Heidelberg; Interested in cancer initiation, (brain) metastases and the tumor microenvironment

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Reposted by Nils Hebach
NEJM.org @nejm.org · 22/09/2026
In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone. Full NHS-Galleri trial results: nej.md/4xRZN5L
A bar chart from an Original Article published in the New England Journal of Medicine article titled "Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis." The chart shows the distribution of the route to cancer diagnosis according to trial group after three annual screening rounds. The trial name, NHS-Galleri, is in parentheses after the title. The NEJM identity sits at the bottom.
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Hellmut Augustin @hellmutaugustin.bsky.social · 22/08/2026
Congratulations to Ki Hong Lee & Moritz Jakab for their landmark paper in Nature Commun showing that endothelial cell Wnt-mediated angiocrine signaling in the liver is controlled by hemodynamic forces and not by oxygen gradients. Stunningly beautiful work! www.nature.com/articles/s41467-026-76966-7
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Matthias Eberl @eberlmat.bsky.social · 20/08/2026
"Institutions must avoid a dangerous and emerging misconception: that academic research should be financially self-sustaining. Historically, society has not expected classical music to justify its existence through commercial profitability, and neither should it expect fundamental science to do so."
nature.com
Building clinical translation on squares of discovery - Nature Reviews Immunology
Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized ‘squares of discovery’ in which deep...
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Junhong Choi @choijunhong.bsky.social · 11/08/2026
Excited to share the first preprint from our lab! We combined a DNA Typewriter lineage recorder with clone-resolved founder profiling to find what makes metastatic potential heritable in lung cancer xenografts. 1/13 www.biorxiv.org/content/10.6...
biorxiv.org
Time-resolved lineage recording reveals a pre-existing, heritable cell state underlying metastatic potential
Metastasis causes most cancer deaths, yet no recurrent mutation specifically drives it, raising the possibility that metastatic potential is a non-genetic yet heritable cell state. Classic experiments...
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Jay Shendure @jshendure.bsky.social · 31/07/2026
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
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Julia Belk @juliabelk.bsky.social · 30/07/2026
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science. Today @nature.com, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com
Somatic mutations reveal the ontogeny of microglia in human aging - Nature
Nature - Somatic mutations reveal the ontogeny of microglia in human aging
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Ali Maximilian Erturk @erturklab.bsky.social · 28/07/2026
Brain vascular aging isn’t a single path. Our new work shows that the aging brain diverges into two states: 🧠 Hypovascular (expected) 🧠 Hypervascular (surprising), with BBB leakage, inflammation and cognitive decline. Our study👇🏻: www.biorxiv.org/content/10.6...
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Elizabeth McKenna @elizsmckenna.bsky.social · 22/07/2026
Now online in Cancer Discovery @aacrjournals.bsky.social: LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis - by Xiaowen Zhang, Mahak Singhal, @hellmutaugustin.bsky.social, and colleagues doi.org/10.1158/2159... @dkfz.bsky.social @uniheidelberg.bsky.social
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Hellmut Augustin @hellmutaugustin.bsky.social · 21/07/2026
Congratulations to Xiaowen Zhang for her spectacular publication in Cancer Discovery identifying a subpopulation of LPL-expressing intratumoral endothelial cells that decisively controls the anti-tumor immune response in liver metastases. See: aacrjournals.org/cancerdiscov...
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Arvind Iyer @arvind-k-iyer.bsky.social · 10/07/2026
1/ My PhD work is finally out in @natgenet.nature.com ! 🎉 We introduce SelectSim and map co-mutations across >70,000 tumors and 100+ cancer types and subtypes. Cancer mutations do not act in isolation; their combinations can shape tumor evolution. www.nature.com/articles/s41...
nature.com
Evolving patterns of co-mutations from tumor initiation to metastatic progression - Nature Genetics
SelectSim uses cancer and healthy tissue sequencing datasets to identify co-mutations that occur more or less frequently than would be expected by chance. Differences in co-mutation patterns observed ...
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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 09/07/2026
Sensory neurons encode long-term inflammatory memory that promotes gastric regeneration and tumorigenesis www.biorxiv.org/content/10.64898/20…
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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 08/07/2026
Sex-Dimorphic Neural Memory Shapes Pancreatic Tissue Resilience www.biorxiv.org/content/10.64898/20…
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William Hill @drwilliamhill.bsky.social · 04/06/2026
Incredible to see our work out today in Cell: "Plasma signals of lung tumor promotion for molecular cancer prevention." www.cell.com/cell/fulltex...
cell.com
Plasma signals of lung tumor promotion for molecular cancer prevention
A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based lung cancer risk reduction and demonstrates how diverse tumor-promoting factors converge on the induction of an al...
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NEJM.org @nejm.org · 31/05/2026
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM #ASCO26
Graph from a study published in the New England Journal of Medicine on daraxonrasib versus chemotherapy for metastatic pancreatic cancer. The x-axis represents months, and the y-axis shows the percentage of patients alive. Two lines indicate survival rates: daraxonrasib (blue) and chemotherapy (gray). The bottom section lists patients at risk over time. Title and journal logo are included.
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Jalal @jalalahmedlab.bsky.social · 24/05/2026
Thrilled to share our new paper out today in @NatureCancer:A single dose of RT makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues. (1/14) nature.com/articles/s43018-026-01167-6
nature.com
Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases - Nature Cancer
Ahmed and colleagues show that, by promoting ‘dressing’ of intact tumor target antigens onto dendritic cells, tumor irradiation enhances chimeric antigen receptor T cell persistence and efficacy in lu...
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The Francis Crick Institute @crick.ac.uk · 19/05/2026
Researchers at the Crick have uncovered how lung tumours can hijack the activity of nearby nerves to weaken the body’s immune response. This research was led by Ya-Hsuan Ho and Giacomo Bregni, with corresponding author Leanne Li. www.crick.ac.uk/news/2026-05...
crick.ac.uk
Nerve signals disrupt immune response to lung cancer
Sensory nerve activity disrupts how immune cells are organised within lung tumours, weakening the immune response.
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Nils Hebach @nilshebach.bsky.social · 15/05/2026
Happy #FluorescenceFriday! Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation. More in our recent preprint : www.biorxiv.org/content/10.6...
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Nils Hebach @nilshebach.bsky.social · 13/05/2026
Our new preprint on calcium signaling in brain metastases is now on bioRxiv! Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!
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Jamal-Hanjani Lab @jamal-hanjani-lab.bsky.social · 29/04/2026
Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...
nature.com
Evolutionary characterization of lung cancer metastasis - Nature
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
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Matthia Karreman @matthiakarreman.bsky.social · 17/04/2026
How does the nervous system influence cancer ... and vice versa? Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead. www.sciencedirect.com/science/arti...
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Prof Jenny Rohn @jennyrohn.bsky.social · 15/04/2026
The UK rejoining Erasmus is the best science news for a while! #AcademicSky www.gov.uk/government/n...
gov.uk
UK and EU finalise agreement to bring UK into Erasmus+ in 2027
Thousands across the UK set to benefit from re-opening of the historic Erasmus+ programme
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Waggoner Lab @labwaggoner.bsky.social · 14/04/2026
Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression @cellcellpress.bsky.social www.cell.com/cell/fulltex...
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Ashwin Varma @ashwinvarma97.bsky.social · 05/04/2026
Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.
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Jason Buenrostro @jbuenrostro.bsky.social · 26/03/2026
It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s41... And a special shoutout to the lead author @snaga13.bsky.social A 🧵
nature.com
Epigenetic memory of colitis promotes tumour growth - Nature
Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...
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Barts Cancer Institute (Queen Mary University of London) @qmbci.bsky.social · 25/03/2026
🔬 Watch how cancer and immune cells interact in a living system. Scientists at BCI have developed mini lab-grown ovarian tumours that recreate the complex neighbourhood of cells in patients. Published today in @natcomms.nature.com. Read more: bit.ly/4bMCrVg 🧪 #medsky #oncosky @qmul.bsky.social
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Waggoner Lab @labwaggoner.bsky.social · 20/03/2026
AP-1 mediates cellular adaptation and memory formation @natcomms.nature.com @pennmedicine.bsky.social @arjunraj.bsky.social @penngenetics.bsky.social www.nature.com/articles/s41...
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Alex Schier @schierlab.bsky.social · 12/03/2026
Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
science.org
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...
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Oded Rechavi @odedrechavi.bsky.social · 12/03/2026
Humanity is notorious for leaving problems for the next generations, but animals reveal the biology: C. elegans develop germline tumors if THEIR GRAND GRANDPARENTS’ cells fail to clear garbage from their body cavity… What the hell, you ask? Read our new preprint! 👇 www.biorxiv.org/content/10.6...
biorxiv.org
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The Francis Crick Institute @crick.ac.uk · 04/03/2026
Two Crick group leaders are joining Cancer Grand Challenges teams to tackle big questions in cancer research. Leanne Li leads a team studying how tumours interact with the nervous system, and Vivian Li joins a @ucl.ac.uk-led team working to rewire cancer cells. 🔗 www.crick.ac.uk/news/2026-03...
Portrait shots of two people looking into the camera.
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Journal of Experimental Medicine @jem.org · 02/03/2026
@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/... 📘 In our #Lymphatics collection: rupress.org/jem/collecti...
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Lydia Becker Institute @lydiabeckeriii.bsky.social · 17/02/2026
This week, we're joined by @drwilliamhill.bsky.social from @cruk-mi.bsky.social for the next in our @britsocimm.bsky.social MIG Seminar series: "Signals and Mechanisms of Lung Cancer Promotion by Air Pollutants” 📆 Thursday 19th Feb 🕛 12:00 PM 📍 Michael Smith Lecture Theatre #ImmunoSky
British Society for Immunology MIG seminar, Dr William Hill, CRUK Manchester Institute:

"Signals and Mechanisms of Lung Cancer Promotion by Air Pollutants”

Thursday 19th February
12 pm
Michael Smith Lecture Theatre
Lydia Becker Institute of Immunology and Inflammation
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European Research Council (ERC) @erc.europa.eu · 13/02/2026
“Trust in scientists is gone!” Maria Leptin points to USA, adding: “To be resilient we must trust that the best researchers know where the scientific frontiers lie and keep diversity in research now for our future. Blue sky science is key to be prepared.” BMW Foundation Energy Security Hub
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Elizabeth McKenna @elizsmckenna.bsky.social · 06/02/2026
The February issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features work by @danielazorin.bsky.social, Dirk Hoffmann, Sophie Heuer, Frank Winkler, et al. on targeting tumor microtubes to disrupt GBM cell networks. Read that & more: aacrjournals.org/cancerdiscov...
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Roychoudhuri Lab @roychoudhurilab.bsky.social · 03/02/2026
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Waggoner Lab @labwaggoner.bsky.social · 26/01/2026
Tumor-associated macrophages directly stimulate neurite outgrowth, revealing a dual role in enhancing intratumoral nerve growth and promoting neural repair after severe spinal cord injury @cp-immunity.bsky.social www.cell.com/immunity/ful...
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Tom Ellis @proftomellis.bsky.social · 16/01/2026
So cool - someone finally hacked 'the vault'. www.science.org/doi/10.1126/...
science.org
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
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Waggoner Lab @labwaggoner.bsky.social · 07/01/2026
An in-depth analysis of nutrient availability across mouse tissues reveals their influence on the spread of cancer to other organs @mghsteelelabs.bsky.social @harvardmed.bsky.social @geochurch.bsky.social www.nature.com/articles/s41... @nature.com www.nature.com/articles/d41...
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Nature @nature.com · 17/12/2025
Nature research paper: Transient hepatic reconstitution of trophic factors enhances aged immunity go.nature.com/4pD0f3H
go.nature.com
Transient hepatic reconstitution of trophic factors enhances aged immunity - Nature
Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.
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Jeremy Borniger @jborniger.bsky.social · 15/12/2025
www.cell.com/neuron/fullt... new paper from our group demonstrating how breast tumors dysregulate rhythms in the HPA axis to drive their own growth. Great collaboration with the @corina-amor.bsky.social and @cheadlelab.bsky.social labs @cshlnews.bsky.social
cell.com
Aberrant hypothalamic neuronal activity blunts glucocorticoid diurnal rhythms in murine breast cancer
Gomez, Wu, et al. demonstrate that breast cancer promotes blunted glucocorticoid diurnal rhythms via disinhibition of PVNCRH neurons. Restoration of normal glucocorticoid rhythms via endogenous activa...
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Randall Munroe @xkcd.com · 26/11/2025
Fifteen Years xkcd.com/3172/
Comic. Panels up to the 10-year point are grayed out. New panels since the Ten Years comic, which chronicles the first ten years of PERSON 1's journey with cancer: (1) [two people in bed] PERSON 1 (woman): One more chapter? PERSON 2 (man): Don’t we both have to get up early? PERSON 1: Nnnnnggggh PERSON 2: Sure, good point. (2) [many people wearing masks, walking while looking at graphs on their phones] (3) [birds landing on people] PERSON 2 in beanie and scarf: Hah! They like *my* seeds best. PERSON 1 in scarf holding phone with a bird sitting on it: Wait, how do I take a picture of this one? (4) [two people rowing boats with tree landscape] (5) [Person 1 carries overflowing stack of things to Person 2 in bed] PERSON 1: I brought you honey lemon tea, more pillows, a cinnamon roll, Tylenol, another blanket, a– PERSON 2: It was just Appendicitis, I’m really– PERSON 1: *It is my turn to take care of you and I am going to do it right!* (6) [Two people in car] (7) [still in car) PERSON 1: Oh my god. PERSON 2: Oh my god. (8) [car driving] PERSON 1: Pull over! PERSON 2: I am! (9) [both people get out of car] (10) [Large colored panel of aurora borealis over water with both people looking on] (11) [Person 1 sits against tree while Person 2 lies on the ground] PERSON 1: Fifteen years. No sign of the cancer. (12) I *am* having some weird symptoms. Joint pain. Fatigue. I think I’m losing my close-up vision. PERSON 2: Yeah. Me too. (13) PERSON 2: I think we’re getting old. (14) PERSON 1: I guess that’s okay. PERSON 2: It’s all I wanted.
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Winkler Laboratory @winklerlab.bsky.social · 21/11/2025
📢 Registration (free!) for the NCI webinar series 'Fueling Cancer Progression by the Nervous System' is open! 🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis 📅 6 exciting topics are covered by leaders in the field 💡!
events.cancer.gov
Fueling Cancer Progression by the Nervous System (Overview) | Events Registration
OverviewThe Fueling Cancer Progression by the Nervous System series will feature six webinars, each exploring the junction between neuroscience and cancer biology to advance our understanding of cance...
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Claire Deo @clairedeo.bsky.social · 13/11/2025
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇 www.biorxiv.org/content/10.1...
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 12/11/2025
We're pleased to announce that @charlesswanton.bsky.social is the 2026 winner of the Mike Price Gold Medal Award! The award will be presented at the EACR 2026 Congress in Budapest, where Charles will present the Keynote Award Lecture. Congratulations 🎉 learn more: magazine.eacr.org/charles-swan...
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Waggoner Lab @labwaggoner.bsky.social · 09/11/2025
Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction @cellcellpress.bsky.social www.cell.com/cell/fulltex... @charlesswanton.bsky.social @ucl.ac.uk
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Ali Maximilian Erturk @erturklab.bsky.social · 04/11/2025
We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
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Adrian Liston @labliston.bsky.social · 28/10/2025
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...
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The Batlle Lab @batllelab.bsky.social · 23/10/2025
🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
aacrjournals.org
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
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Erik Herzog @erikherzog.bsky.social · 22/10/2025
#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...
link.springer.com
Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma - Journal of Neuro-Oncology
Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...
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Elizabeth McKenna @elizsmckenna.bsky.social · 14/10/2025
Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...
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Wilhelm Palm @wilhelmpalm.bsky.social · 09/10/2025
Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
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