Reposted by Arvind Iyer
Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness.
We found that transposable elements sustain stem-like states in AML and predict patient outcomes.
www.nature.com/articles/s41...
nature.com
Alterations of chromatin state at transposable elements rewire stemness in acute myeloid leukemia - Nature Genetics
By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...