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Winkler Laboratory

@winklerlab.bsky.social
1.4K followers 406 following 59 posts

We are the Winkler Laboratory at the UKHD and DKFZ Heidelberg Our focus: #cancerneuroscience of #braintumors ( #glioblastoma #brainmetastases), and beyond. We use #intravitalimaging , #calciumimaging, #preclinicalmodels and more, to tackle these diseases

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Federation of European Neuroscience Societies - FENS @fens.org · 27/08/2026
Day 3️⃣ of the Brain Conference on Cancer Neuroscience! 🧠 👉 Want to learn more about the Brain Conferences? 🔗 buff.ly/I3AtVSv @brainprize.org @naddenmark.bsky.social
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Frankfurt Cancer Institute @loewe-fci.bsky.social · 08/07/2026
⏰ Only 3 days left to register for the #FrankfurtCancerConference 2026! Join the #translational #cancer research community for inspiring talks, scientific exchange, and plenty of networking opportunities. Meet leading experts and connect with fellow researchers. 👉 www.frankfurtcancerconference.org
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Erik @epikrisa.bsky.social · 07/07/2026
Now lectures on cancer neuroscience by Brain prize winners Winkler and Monje. Happy to be a small part of the field. I feel some hope for the future of currently lethal glioma in adults and children.
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The Brain Prize @brainprize.org · 02/07/2026
In just five days at the FENS Forum in Barcelona, the 2025 Brain Prize winners, Frank Winkler and Michelle Monje will deliver The Brain Prize Lecture. For more information: www.fens.org Federation of European Neuroscience Societies - FENS #BrainPrize #Neuroscience #FENS
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Frankfurt Cancer Institute @loewe-fci.bsky.social · 18/06/2026
✨ Introducing the speakers of our #TumorMicroenvironment sessions at the #FrankfurtCancerConference 2026 – Part 1: ▫️Leila Akkari @leilaakkari.bsky.social ▫️Ihsan Ekin Demir ▫️Frank Winkler @winklerlab.bsky.social 📆 Sep 2–4, Frankfurt 🔗 www.frankfurtcancerconference.org 👉 Deadline: June 25, 2026
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Areeba Patel @areebap.bsky.social · 10/06/2026
1/n Excited to share our new paper in Nature Cancer 🦀 Meet Hetairos (Greek- “companion”): an AI model that predicts >100 methylation-defined CNS tumour subtypes directly from a routine H&E slide 🧠 State of the art diagnostics- from the slide that’s already on every pathologists’ desk 🧵
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Cancer Neuroscience Heidelberg @cn-hd.bsky.social · 26/05/2026
📢 #CancerNeuroscience Online Seminar with @michellemonje.bsky.social from Stanford University, USA. Title: The Neuroscience of Brain Cancers June 16, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
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Cancer Neuroscience Heidelberg @cn-hd.bsky.social · 18/05/2026
📢 #CancerNeuroscience Online Seminar with Manuel Valiente from CNIO, Madrid, Spain. Title: Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity June 9, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
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Cancer Neuroscience Heidelberg @cn-hd.bsky.social · 18/05/2026
📢 #CancerNeuroscience Online Seminar with Manuel Valiente from CNIO, Madrid, Spain. Title: Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity June 9, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
us06web.zoom.us
Welcome! You are invited to join a meeting: Cancer Neuroscience Online Seminar - Manuel Valiente. After registering, you will receive a confirmation email about joining the meeting.
Manuel Valiente, DVM, PhD - Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity
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Nils Hebach @nilshebach.bsky.social · 15/05/2026
Happy #FluorescenceFriday! Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation. More in our recent preprint : www.biorxiv.org/content/10.6...
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nielsolshausen.bsky.social @nielsolshausen.bsky.social · 13/05/2026
Super excited to see our new preprint on calcium signalling in brain metastases now out on bioRxiv! Very thankful to be part of @winklerlab.bsky.social and working so closely with @nilshebach.bsky.social under the guidance of @matthiakarreman.bsky.social and Frank Winkler and all our collaborators.
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Nils Hebach @nilshebach.bsky.social · 13/05/2026
Our new preprint on calcium signaling in brain metastases is now on bioRxiv! Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!
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Matthia Karreman @matthiakarreman.bsky.social · 13/05/2026
What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇
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Federation of European Neuroscience Societies - FENS @fens.org · 08/05/2026
📢 Late registration for the #BrainConference on Cancer Neuroscience is OPEN! 📍 Rungstedgaard, Denmark 🗓️ 25-28 Aug 2026 👉 Register by 12 July: buff.ly/3IpvSDe @brainprize.org @naddenmark.bsky.social
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Deutsches Krebsforschungszentrum (DKFZ) @dkfz.bsky.social · 07/05/2026
Scientists from DKFZ and HI-STEM have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). This discovery lays an important foundation for more precise and long-term successful treatment strategies. @cp-cellstemcell.bsky.social t1p.de/brfxf
t1p.de
Leukemia stem cells cause treatments to fail - Findings open new avenues to overcome resistance
Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). The...
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Barbara Marte @barbmarte.bsky.social · 07/05/2026
new out in Nature www.nature.com/articles/s41...
nature.com
Androgen loss accelerates brain tumour growth via HPA axis activation - Nature
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
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Motori Lab @motorilab.bsky.social · 17/04/2026
Check out this great review from @winklerlab.bsky.social and colleagues: cancer neuroscience is going to rewrite everything we thought we knew about oncology - and we're just getting started!🧠🔍
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Matthia Karreman @matthiakarreman.bsky.social · 17/04/2026
How does the nervous system influence cancer ... and vice versa? Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead. www.sciencedirect.com/science/arti...
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Cell - a Cell Press journal @cp-cell.bsky.social · 16/04/2026
New issue alert👉https://cell.com/cell/current On the cover: For the Hallmarks of Cancer's 25th anniversary, the cover illustrates its enduring impact across the cancer research community, uniting scientists, clinicians, patients, and educators to drive progress.
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Winkler Laboratory @winklerlab.bsky.social · 17/04/2026
What are the current and emerging topics in Cancer Neuroscience, and what comes next for the field? In our new review, now online @cp-cell.bsky.social, we discuss previous and ongoing research from leading laboratories and propose future directions for research. 🧠🔬 Curious? See link below 😀👇
sciencedirect.com
Cancer neuroscience: The past, the present, and the road ahead
Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, …
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Cancer Neuroscience Heidelberg @cn-hd.bsky.social · 14/04/2026
📢 #CancerNeuroscience Online Seminar with Ofer Yizhar, from Weizmann Institute of Science, Israel. Title: “Optogenetic modulation of neural circuits” This virtual seminar takes place on April 28, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
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Trends in Cancer @cp-trendscancer.bsky.social · 14/04/2026
Neural circuits in lung adenocarcinoma modulate immunosurveillance
dlvr.it
Neural circuits in lung adenocarcinoma modulate immunosurveillance
Recent evidence from a study published in Nature by Wei et al. reveals a bidirectional tumor–brain axis in lung cancer that suppresses immune surveillance by reprogramming macrophages and disabling T cell responses. These findings highlight neuroimmune signaling as a key regulator of cancer progression and a promising therapeutic target.
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Eric H Chang @changsbrain.bsky.social · 23/03/2026
A great honor to have 2025 Brain Prize recipient Professor Frank Winkler come and give a talk at the Feinstein Institutes @northwellhealth.bsky.social about recent work in cancer neuroscience! @winklerlab.bsky.social
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Federation of European Neuroscience Societies - FENS @fens.org · 10/03/2026
📢 Registration for the #BrainConference on the 'Neural Foundations of Communication' is OPEN! 🇬🇷 Join us in #Crete for a programme full of scientific sessions, networking opportunities, and social events! 📍 Crete, Greece 🗓️ 5–8 October 2026 🔗 Register today: buff.ly/vUAl678
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Frankfurt Cancer Institute @loewe-fci.bsky.social · 09/03/2026
📢 Call for Abstracts - Frankfurt Cancer Conference 2026 Present your research September 2-4 as a poster or get selected for a short talk. Share your work, get feedback, and connect at the international #FrankfurtCancerConference. 📆 Deadline: March 26, 2026 🔗 www.frankfurtcancerconference.org
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Winkler Laboratory @winklerlab.bsky.social · 20/01/2026
Coming soon: The #BrainConference on #CancerNeuroscience: 🗺️ Rungstedgaard (CPH,DM) 📅 25-28 Aug 2026 Please join chairs @michellemonje.bsky.social & Frank Winkler and an great line up of speakers to discuss the newest findings. Early bird registration is now open 👇 @fens.org #FENS #Neuroscience
fens.org
The Brain Conference on CANCER NEUROSCIENCE - Federation of European Neuroscience Societies
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The Brain Prize @brainprize.org · 21/10/2025
“I was advised that having multiple children would detract from my scientific career. But I actually think that it has greatly benefited it.” Prof. @michellemonje.bsky.social, Neurology and Neurological Sciences at Stanford University, #BrainPrize2025. #Neuroscience youtu.be/f7sbSuWie5A?...
youtu.be
Balancing a career in science and personal life
YouTube video by BrainPrize
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The Brain Prize @brainprize.org · 28/10/2025
“In the laboratory we find truth. We find something that was not known before. We hope to translate that back to patients to improve care, to improve treatments, and outcomes.” @michellemonje.bsky.social, Neurology and Neurological Sciences at Stanford University, #BrainPrize. youtu.be/-mVeQuQfJ1E
youtu.be
Combining research and clinical practice
YouTube video by BrainPrize
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The Brain Prize @brainprize.org · 04/11/2025
“Basic science often gives you a hard time. There are periods, weeks, even months, sometimes years, where you are not moving forward. But in the end, the rewards are enormous” Frank Winkler, prof. of Neuro-Oncology, Brain Prize winner 2025. #Neuroscience #TheBrainPrize youtu.be/7_CZz4gFyqU
youtu.be
The value of perseverance in science
YouTube video by BrainPrize
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The Brain Prize @brainprize.org · 02/12/2025
How do nervous system tumours reshape neural circuits? Join the 2nd #BrainPrize2025 webinar with @michellemonje.bsky.social and Frank Winkler moderating a panel of leading researchers. #neuroscience #webinar youtu.be/Lj8pYKhGqKM
youtu.be
Cancer remodelling of neural circuits
YouTube video by BrainPrize
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Winkler Laboratory @winklerlab.bsky.social · 05/12/2025
Now online: the @brainprize.org #webinars on #cancerneuroscience! 🧠🔬 Learn more about the #neuroscience of #braincancer, #cancer remodelling of #neuralcircuits, and #PNS #nerve regulation of #cancer from experts in the field! 👇 Enjoy!
brainprize.org
The Brain Prize webinar series 2025
Watch The Brain Prize webinars on Cancer Neuroscience featuring leading experts sharing advanced research on cancer–nervous system interactions.
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Deutsche Forschungsgemeinschaft @dfg.de · 27/11/2025
Im Nachgang zum Webinar "DFG-Förderung für #ClinicianScientists" (6. November 2025, >280 Teilnehmer*innen) 👇 haben wir alle Informationen und auch die Präsentationsfolien auf unserer Website zusammengestellt - jetzt unter: ➡️ www.dfg.de/de/foerderun...
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The Brain Prize @brainprize.org · 25/11/2025
Neurons help gliomas grow. Discover how in the first #BrainPrize2025 webinar with @michellemonje.bsky.social and Frank Winkler - pioneering insights reshaping brain cancer research. #braincancer #neuroscience #webinar youtu.be/k6Pgbq5IZGI?...
youtu.be
The Neuroscience of Brain Cancers
YouTube video by BrainPrize
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Winkler Laboratory @winklerlab.bsky.social · 21/11/2025
📢 Registration (free!) for the NCI webinar series 'Fueling Cancer Progression by the Nervous System' is open! 🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis 📅 6 exciting topics are covered by leaders in the field 💡!
events.cancer.gov
Fueling Cancer Progression by the Nervous System (Overview) | Events Registration
OverviewThe Fueling Cancer Progression by the Nervous System series will feature six webinars, each exploring the junction between neuroscience and cancer biology to advance our understanding of cance...
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eLife @elife.bsky.social · 13/11/2025
1/ New ‘fundamental’ study shows that neuronal migration depends on blood flow in the adult mammalian brain. elifesciences.org/articles/995...
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Johanna Joyce @johannajoyce.bsky.social · 05/11/2025
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬 An amazing set of resources for all scientists working on the brain! 🧠 Immersive feature: www.nature.com/immersive/d4... 🧠 Perspective: www.nature.com/articles/s41...
Cover of this week's Nature showing a brain rendering

Cover caption from the journal:
Brain development:
Our ability to process information into complex emotions, behaviours and decisions relies on the rich diversity of cell types that make up the human brain. Uncovering the molecular and cellular events that take place during brain development could reveal not only the mechanisms that give rise to this diversity but also shed light on how this process might go awry in neurodevelopmental disorders such as autism and schizophrenia. In this week’s issue, the BRAIN Initiative Cell Atlas Network (BICAN) builds on its previous work creating atlases of cell types in the adult mouse, non-human primate (NHP) and human brains to present cell-type atlases of the developing human, mouse and NHP brains. Across a suite of papers, nine of which are published in Nature, the researchers uncover the complex programs through which cell types emerge during brain development in humans and animals, revealing both the shared and unique features of the human brain. The latest work, along with future research directions, is summed up in a Perspective article by Tomasz Nowakowski and colleagues
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Wolfgang Wick @wickwolfgang.bsky.social · 23/10/2025
Autumn in #Heidelberg. We are excited to welcome the brightest scientists in Neurooncology at the 8th Harvard Heidelberg Alliance in #Neurooncology! @dkfz.bsky.social @uniheidelberg.bsky.social
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Winkler Laboratory @winklerlab.bsky.social · 19/10/2025
Fantastic presentation @melinamueller.bsky.social ! We are very proud to have you in the lab and looking forward to future discoveries 🤩 #UNITE-GBM #cancerneuroscience @neurooncologyhd.bsky.social
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Melina Müller @melinamueller.bsky.social · 19/10/2025
Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social! We had a great time in Bilbao @winklerlab.bsky.social🧠.
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David Hausmann @hausmanndavid.bsky.social · 19/10/2025
It’s a wrap! What a fantastic and inspiring #EANO2025. It was great to share projects and ideas. Looking forward to Rome. @winklerlab.bsky.social @hlsalliance.bsky.social @cn-hd.bsky.social @eanoassociation.bsky.social
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Matthia Karreman @matthiakarreman.bsky.social · 18/10/2025
Very much looking forward to presenting our work on the #cancerneuroscience of #brainmetastasis in session OS10 later today #EANO2025 ! #preclinical #NeuroOncology
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 18/10/2025
We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉 The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
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Elizabeth McKenna @elizsmckenna.bsky.social · 14/10/2025
Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...
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Lily Keane @lilykeane.bsky.social · 14/10/2025
Attending the @helloeacr.bsky.social Cancer Neuroscience meeting in Bilbao, Spain today? Check out my PhD student @austejabaleviciute.bsky.social poster in this evenings session "Targerting Microglia in Diffuse Midline Glioma - heating up the Tumour Microenvironment'
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Winkler Laboratory @winklerlab.bsky.social · 14/10/2025
📣 Today is the day!! 📣 The @helloeacr.bsky.social #CancerNeuroscience conference will kick off in beautiful Bilbao, Spain. 🇪🇸 🧠🤩 It’s an excellent program 😍 We are looking forward to many interesting new insights and discussions! 💡 See you in a few hours! 👋 #cancer #neuroscience #EACRconference
eacr.org
Introduction | Cancer Neuroscience | The European Association for Cancer Research
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Winkler Laboratory @winklerlab.bsky.social · 14/10/2025
Congratulations 🎊! Very well deserved 😊🤩🥳
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Health + Life Science Alliance Heidelberg Mannheim @hlsalliance.bsky.social · 13/10/2025
Presenting recipients of our 2025 Stimulator Grant: 👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism. 🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social @dkfz.bsky.social
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Cancer Neuroscience Heidelberg @cn-hd.bsky.social · 13/10/2025
#CancerNeuroscience Online Seminar, October 21, 5-6 PM, CET. Elizabeth Repasky, Roswell Park Comprehensive Cancer Center, Buffalo, NY - Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice. us06web.zoom.us/meeting/regi...
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The Brain Prize @brainprize.org · 13/10/2025
Come and join The Brain Prize Lecture from Larry Abbott, US, at #ECNP2025. The 2024 prize co-recipient will present work on how connectomics advance our understanding of two neural systems, as well as its implications for neurology. Details: www.ecnp.eu/congress2025... #TheBrainPrize #neuroscience
The Brain Prize lecture by Larry Abbott at ECNP 2025
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Daniel D. Azorín @danielazorin.bsky.social · 10/10/2025
My main PhD project is out in #CancerDiscovery @theaacr.bsky.social We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy. Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
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