Researchers at Washington University in St. Louis have found a way to better track circadian brain signals that synchronize the body clocks.

Researchers at Washington University in St. Louis find the timing of biopsy can affect how doctors diagnose tumors and when those cancers may be more sensitive to chemotherapy.

Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...

Gonzalez-Aponte et al. identify daily glucocorticoid receptor signaling as an intrinsic driver of glioblastoma (GBM) progression and a synchronizer of tumor clock gene expression to the host. This work provides an intrinsic circadian driver, and therapeutic target, to slow GBM growth, and offers considerations for glucocorticoid use in the clinic.

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