One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human.

In the rapidly evolving field of biomedical research, the role of animal models has long been a topic of scientific and ethical debate. However, despite advancements in alternative modeling approaches...

We generated a disease-relevant heterozygous Adnp mouse model that recapitulates key molecular and behavioural features observed in patients with Helsmoortel-Van der Aa syndrome. Our findings demonstr...

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Nature Communications - In this study, the authors develop CaMPARI-seq to link neural activity with molecular profiles in larval zebrafish. They identify inhibitory pretectal neurons required for...

Myocardial infarction results in irreversible cardiomyocyte loss and fibrotic remodeling in adult mammals, whereas some vertebrates retain the abil...

Pharmaco-behavioral screens in scalable in vivo systems have critical advantages for drug discovery relevant to large-effect autism spectrum disord...

The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We repor...

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Welcome! We study the cellular interactions between neurons and oligodendrocytes, which produce myelin in the central nervous system. Myelination - the process by which oligodendrocytes ensheath neuro...

Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brai...

Axolotls can completely rebuild their thymus, a key immune organ

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

A lifelong passion for writing helped the neuroscientist land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes.

CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

Peripheral cancer inhibits amyloid pathology and rescues cognition of Alzheimer’s disease through secretion of cystatin-c (Cyst-C), which binds amyloid oligomers and activates TREM2 in microglia and e...

Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...

Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...

Reciprocal signaling between intracellular lysosomes and the extracellular matrix supports brain health.