The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuronal and glial cell-adhesion molecules, including n...

Axon diameter is important for action potential conduction speed, but what molecular pathways influence this neuronal property? This study reports a high-resolution imaging-based chemical screening pi...

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linea...

Nature Neuroscience - In this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growing possibilities of spatial transcriptomics by...