Very happy to share this study from our group and colleagues now out in Science!
We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function
#Zebrafish #Gut
science.org
IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota
The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We repor...
