During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

Phosphatase and tensin homologue-induced kinase 1 (PINK1) is a serine/threonine kinase that plays roles in mitophagy, cell death, and regulation of cellular bioenergetics. Current approaches for study...

UCLA researchers have created miniature stem cell-based organoid models of human lungs, hearts and brains to study how hantaviruses — rare but often deadly viruses spread by rodents — infect the body....

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

Los Angeles, CA — Today the Los Angeles City Council voted to oppose SB 79, a state bill designed to expand affordable housing near major transit stops. In doing so, councilmembers repeated discredite...

In a first-of-its-kind clinical trial, UCLA scientists have shown it’s possible to reprogram a patient’s blood-forming stem cells to generate a continuous supply of functional T cells, the immune syst...

Researchers from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received a $3.5 million grant from the National Institutes of Health to study and develop ...

About 15,000 pairwise interactions within S. epidermidis from 18 people in 6 families reveal the antagonism and molecular trade-offs that shape the skin microbiota.

The Republican controlled Congress and Senate are voting on budgets that will decimate Medicaid and millions of Californians will lose their healthcare - just so they can give more tax breaks to their...

Post-translational modifications (PTMs) alter the proteome in response to intra- and extracellular signals, providing fundamental information processing in development, homeostasis and disease. Here, ...

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"I've never seen government racial discrimination like this," the judge said.

Podcast Episode · The Tortured Proteins Department · 06/14/2025 · 40m

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