Organ functionality requires the precise coordination of diverse tissues during development. Halfway through Drosophila embryogenesis, two lateral epidermal sheets stretch to fuse at the dorsal midlin...

How does the corneal lens in the fly eye acquire its light-focusing shape? This study shows that centrally located cells produce large amounts of chitin to form the thick central corneal lens, while p...

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Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Summary: This Review discusses recent insights into the factors controlling enhancer specificity and how this might help us understand the genetic basis of human disease.

Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...

Author summary The uptake of materials from outside the cell and their subsequent delivery to specific intracellular locations are essential for cell function and survival. Two of the mechanisms that ...

An accessible light-sheet microscope delivers subcellular-resolution, multicolor volumetric, and live-cell imaging, lowering barriers to state-of-the-art performance.

Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...

A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.

Organ repair and growth rely on coupling tissue-wide membrane depolarization with intracellular proliferative signaling.

Summary: Lipocalins and SCARBs are lipid transporters that influence susceptibility to infection and disease. This study shows that lipocalin and SCARB mutations affect the organization of a protectiv...

Somatic gonadal sex fate must be actively upheld throughout adulthood to support proper gametogenesis, but how do adult tissues maintain their sexual identity? This study identifies a post-transcripti...

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