Summary: We identify FGD1 as a regulator of suprabasal adherens junction remodeling that restrains actomyosin contractility to coordinate cytoskeletal organization and epithelial tissue mechanics.

Les scientifiques établis au Canada peinent plus que jamais à obtenir le financement nécessaire à leurs projets.

Abstract. Intrinsic and adaptive resistance to therapy remain major barriers to effective cancer treatment. Diverse resistance mechanisms, including epithelial-mesenchymal transition, enhanced toleran...

During embryogenesis, cells self-organize into patterns that support tissue-specific functions, but how these collective cellular behaviors are coordinated remains unclear. This study shows that the R...