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Kevin Dean

@kevin-dean.bsky.social
501 followers 174 following 202 posts

Incoming Founding Head of Integrated Imaging Systems, MindSpan Institute. Assistant Professor, UT Southwestern. mindspaninstitute.org www.dean-lab.org thedeanlab.github.io

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Reposted by Kevin Dean
Heather Brown-Harding @microscopyed.bsky.social · 30/09/2026
One of this morning's talks is @kevin-dean.bsky.social explaining how to do cyclic IF for ExM #I2KxBINA
Kevin at a podium with slide titled "Post-Expansion Cyclic Immunofluorescence"
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Kevin Dean @kevin-dean.bsky.social · 17/09/2026
I’m excited to share that I’ll be joining the Mindspan Institute in Cambridge this November as Founding Head of Integrated Imaging Systems, working with an incredible team to tackle one of the most ambitious projects in neuroscience. mindspaninstitute.org
mindspaninstitute.org
Mindspan Institute
A non-profit creating and applying tools to characterize the molecules and wiring of the human brain, as well as to interpret how they contribute to brain functions and dysfunctions, openly sharing to...
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Kevin Dean @kevin-dean.bsky.social · 15/09/2026
I'm shocked.
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Reposted by Kevin Dean
John Bogovic @bogovicj.bsky.social · 17/07/2026
It's an exciting day for #Fiji users! Now read and write @zarr.dev v3 and #OMEZarr v0.5. Don't want a million tiny files in your #zarr? Shard that sucker! Read the details here forum.image.sc/t/fiji-can-r...
forum.image.sc
Fiji can read and write Zarr3 & OME-Zarr v0.5 (new N5 release!)
Updating your Fiji-Latest installation will give you the newest versions of the N5 library, enabling OME-Zarr v0.5 / Zarr v3 support with sharding! What's new? Reading zarr 3 datasets (sharded and u...
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Kevin Dean @kevin-dean.bsky.social · 16/07/2026
New preprint! Using multiscale ExM/OPM/ASLM, we show that oncogenic drivers leave distinct 3D architectural fingerprints in intact liver tissue: NRAS primarily remodels cell shape, whereas CTNNB1 shifts mitochondrial architecture toward a pericentral-like state. tinyurl.com/kepy33m6
biorxiv.org
Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma
Somatic oncogenic mutations are typically defined by their molecular alterations, yet how they reorganize cellular architecture within intact tissues remain largely unknown. Here, we demonstrate that ...
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Kevin Dean @kevin-dean.bsky.social · 10/07/2026
A fun activity… get some goggles, have something floating just beneath the surface of a pool, and adjust your viewing angle under water. See total internal reflection in action.
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Kevin Dean @kevin-dean.bsky.social · 01/07/2026
We’re adding Blender-based tutorials on optical alignment to ALTAIR: thedeanlab.github.io/altair/getti... Our goal is to make optical alignment more intuitive and accessible for both experts and non-experts working with optical systems. Have an idea for a guide? Let me know!
thedeanlab.github.io
Basics of Optical Alignment — altair documentation
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Reposted by Kevin Dean
Julie Pfeiffer @jkpfeiff.bsky.social · 26/06/2026
Faculty search announcement 2026: Tenure-Track Assistant Professor in Microbiology at UT Southwestern in Dallas. We seek candidates working in microbial pathogenesis (broadly defined). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.
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Kevin Dean @kevin-dean.bsky.social · 23/06/2026
How do places like this exist?
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Reposted by Kevin Dean
Henry De Belly @henrydebelly.bsky.social · 10/06/2026
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
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Kevin Dean @kevin-dean.bsky.social · 08/06/2026
We’re hiring an optical systems engineer / scientist to help build and disseminate Altair, our open, modular light-sheet microscopy platform. Ideal for someone with serious hands-on experience in optical design, Zemax, CAD, alignment, and microscopy. Apply here: www.linkedin.com/jobs/view/44...
linkedin.com
UT Southwestern Medical Center hiring Optical Systems Engineer / Research Scientist in Dallas, TX | LinkedIn
Posted 11:44:16 AM. The Dean Lab in the Lyda Hill Department of Bioinformatics at UT Southwestern Medical Center is…See this and similar jobs on LinkedIn.
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Kevin Dean @kevin-dean.bsky.social · 28/05/2026
Data bite: Why science is becoming less innovative www.economist.com/the-world-in... from The Economist
economist.com
The world in brief | The Economist
Catch up quickly on the global stories that matter
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Kevin Dean @kevin-dean.bsky.social · 21/05/2026
Some stars burn bright, and go dark too soon. Take care of yourself, and seek help when you need it.
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Reposted by Kevin Dean
Reto Fiolka @retof.bsky.social · 12/05/2026
We got multiple times the feedback that oblique plane microscopes are too complex. So how about a detection train with only two photographic lenses? www.biorxiv.org/content/10.6...
biorxiv.org
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Kevin Dean @kevin-dean.bsky.social · 12/05/2026
Altair Direct View OPM Preprint! We built a simplified direct-view oblique-plane microscope for imaging big, optically accessible specimens with a single-objective light-sheet geometry. Delivers... • ~5.4 mm field of view • ~2.6 μm, ~3.4 μm, and ~17.8 μm resolution in X/Y/Z
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Kevin Dean @kevin-dean.bsky.social · 10/04/2026
Some great tutorials here! www.youtube.com/@LiveCellIma...
youtube.com
Live Cell Image Analysis
We are leaders of two NIH-funded research centers with national outreach in cancer cell imaging (grants RM1GM145399 and U54CA268072). This channel provides demonstrations and tutorials for the u-quant...
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Kevin Dean @kevin-dean.bsky.social · 29/03/2026
It’s a Commodore weekend.
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Reposted by Kevin Dean
FocalPlane @focalplane.bsky.social · 09/03/2026
🔬🔦In this Imaging spotlight, Kevin Dean @kevin-dean.bsky.social and team tell us about their motivation for designing Altair-LSFM, describe its key features, how to setup and use the system and their planned developments. focalplane.biologists.com/2026/03/09/i...
focalplane.biologists.com
Imaging spotlight: Altair-LSFM - FocalPlane
Imaging spotlight: Altair-LSFM - News
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Kevin Dean @kevin-dean.bsky.social · 09/03/2026
Photon unlimited contrast. Axially swept light-sheet microscopy using scattering and fluorescence contrast mechanisms. www.spiedigitallibrary.org/conference-p...
spiedigitallibrary.org
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Kevin Dean @kevin-dean.bsky.social · 07/03/2026
I’ve been experimenting with AI agents for coding, and honestly: anyone calling it “AI slop” hasn’t really dabbled with the drug. Give these things the right tools and they absolutely shine. Have an idea? Build it.
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Kevin Dean @kevin-dean.bsky.social · 06/03/2026
www.nature.com/articles/s44...
nature.com
Smart microscopy: adaptive microscope control to improve the way we see life - npj Imaging
npj Imaging - Smart microscopy: adaptive microscope control to improve the way we see life
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Reposted by Kevin Dean
Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 19/02/2026
Altair-LSFM – new high-resolution, open-source, sample-scanning approach to light-sheet fluorescence microscopy for sub-cellular imaging 📹 @john-haug.bsky.social et al @kevin-dean.bsky.social lab UT Southwestern Medical Center in @elife.bsky.social ➡️ bpod.org.uk/archive/2026... with John Ankers
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Kevin Dean @kevin-dean.bsky.social · 19/02/2026
bpod.org.uk
bpod.org.uk
BPoD | Easy Cell
BPoD (Biomedical Picture of the Day) is a free educational resource showcasing biomedical imagery. Managed by the MRC Laboratory of Medical Sciences the website aims to engage the general public. Imag...
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Reposted by Kevin Dean
Alison Tebo @agtebo.bsky.social · 17/02/2026
We’re excited to announce the next Fluorescent Proteins & Biological Sensors conference! Abstract submissions are now open—hope to see you there. www.janelia.org/you-janelia/...
janelia.org
Fluorescent Proteins and Biological Sensors VIII
Organizers Eric Schreiter, HHMI/Janelia Research Campus Alison Tebo, HHMI/Janelia Research Campus Invited Participants Xiaolu Cambronne, University of Texas at Austin Katharine Diehl, University of
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Kevin Dean @kevin-dean.bsky.social · 12/02/2026
Today’s bounty
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Kevin Dean @kevin-dean.bsky.social · 05/02/2026
In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...
doi.org
A high-resolution, easy-to-build light-sheet microscope for subcellular imaging
An accessible light-sheet microscope delivers subcellular-resolution, multicolor volumetric, and live-cell imaging, lowering barriers to state-of-the-art performance.
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Reposted by Kevin Dean
Reto Fiolka @retof.bsky.social · 27/01/2026
We have two funded postdoctoral positions available. Topics encompass: -Next gen light-sheet fluorescence microscopy instrumentation -Structured illumination microscopy and other approaches to extend the resolution limit. -Nonlinear microscopy combined with adaptive optics / phase conjugation
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Kevin Dean @kevin-dean.bsky.social · 26/01/2026
You know a grant is due shortly when your children stop sleeping through the night, and school gets closed for multiple days.
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Kevin Dean @kevin-dean.bsky.social · 20/01/2026
DNA PAINT in a drosophila embryo. I'm impressed. www.cell.com/biophysj/ful...
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Kevin Dean @kevin-dean.bsky.social · 20/01/2026
Navigate can now run entirely with ASI's Tiger Controller, eliminating the NI data acquisition board altogether, simplifying the optoelectronics, and providing deterministic frame-to-frame operation. Documentation coming soon... github.com/TheDeanLab/n...
github.com
GitHub - TheDeanLab/navigate: navigate - open source light-sheet microscope controls
navigate - open source light-sheet microscope controls - TheDeanLab/navigate
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Kevin Dean @kevin-dean.bsky.social · 16/01/2026
My favorite conferences are always at Janelia. I cannot recommend enough... www.janelia.org/you-janelia/...
janelia.org
Imaging Mouse Development
Organizers Isabel Espinosa Medina, HHMI/Janelia Research Campus Kate McDole, MRC Laboratory of Molecular Biology Robert Prevedel, European Molecular Biology Laboratory (EMBL) Hari Shroff,
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Kevin Dean @kevin-dean.bsky.social · 15/01/2026
Oh yeah, we do pay these tariffs...
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Reposted by Kevin Dean
Zach Marin @zacsimile.bsky.social · 09/01/2026
Now out in @natcomms.nature.com: www.nature.com/articles/s41...! The latest GitHub commits/Colab notebooks enable simulation with 3D sequences.
nature.com
Client Challenge
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Kevin Dean @kevin-dean.bsky.social · 08/01/2026
High-res 3D imaging in patient samples + xenografts shows bleb-associated survival signaling is enriched in poorly adherent melanoma cells in vivo. Pharmacologic disruption reduces metastatic burden. @muthrnaturzson.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
In vivo evidence for bleb-induced survival signaling in metastatic melanoma
Bleb signaling is a cellular process in which pressure-driven plasma membrane protrusions generate localized micron-scale membrane curvature that recruits cytosolic septin complexes, assembling signal...
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Kevin Dean @kevin-dean.bsky.social · 03/01/2026
A new book, just out! Includes chapters from Dodt, Ueda, Kubitscheck, Gao, @adamkglaser.bsky.social, Silvestri, and yours truly! link.springer.com/book/10.1007...
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Reposted by Kevin Dean
Reto Fiolka @retof.bsky.social · 02/01/2026
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from @seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online. 20 targets across an entire cell. Mr. Snouty also joined the fun. www.biorxiv.org/content/10.6...
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Kevin Dean @kevin-dean.bsky.social · 02/01/2026
Introducing Cyclically Multiplexed Expansion Microscopy (Cy-ExM): a workflow for 3D nanoscale, high-plex imaging in whole cells. Cryo-preserved ultrastructure + iterative labeling + expansion microscopy → 20 targets in one dataset with ~70 nm lateral resolution. www.biorxiv.org/content/10.6...
biorxiv.org
Unraveling Subcellular Ultrastructure with Cyclically Multiplexed Expansion Microscopy
Despite advances in fluorescence microscopy, spectral overlap and limited resolution hinder the dense mapping of the cellular ultrastructure. To overcome these challenges, we developed Cy-ExM, a high-...
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Kevin Dean @kevin-dean.bsky.social · 01/01/2026
20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
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Kevin Dean @kevin-dean.bsky.social · 26/12/2025
In @elife.bsky.social: Altair-LSFM: A High-Resolution, Easy-to-Build Light-Sheet Microscope for Sub-Cellular Imaging doi.org/10.7554/eLif...
doi.org
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Kevin Dean @kevin-dean.bsky.social · 11/12/2025
Check out this instagram feed…
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Kevin Dean @kevin-dean.bsky.social · 09/12/2025
Interested? Apply on Facebook.
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Kevin Dean @kevin-dean.bsky.social · 08/12/2025
RESOLFT time lapse imaging empowered by deep learning. www.researchsquare.com/article/rs-8...
researchsquare.com
RESOLFT time lapse imaging empowered by deep learning
Capturing the dynamic interplay of proteins and organelles within cells requires microscopy methods with high spatial and temporal resolution. RESOLFT nanoscopy demonstrated great potential for live c...
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Kevin Dean @kevin-dean.bsky.social · 08/12/2025
Cell Modeling in Space and Time, at Cold Spring Harbor. meetings.cshl.edu/meetings.asp...
meetings.cshl.edu
Cell Modeling in Space and Time
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Kevin Dean @kevin-dean.bsky.social · 03/12/2025
Fun to see photos from the @mesospim.bsky.social Symposium this last October.
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Kevin Dean @kevin-dean.bsky.social · 23/11/2025
Flew over Greenland yesterday, and it is astonishingly beautiful.
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Kevin Dean @kevin-dean.bsky.social · 21/11/2025
I simply love Dask.
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Kevin Dean @kevin-dean.bsky.social · 13/11/2025
www.nature.com/articles/s41...
nature.com
Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology
A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.
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Reposted by Kevin Dean
Wildtype One @wildtypeone.bsky.social · 12/11/2025
Finally, the love child of AI and microscopy. A major advance. Thanks for sharing @kevin-dean.bsky.social
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Kevin Dean @kevin-dean.bsky.social · 11/11/2025
A game changer in our hands... www.nature.com/articles/s41...
nature.com
Universal consensus 3D segmentation of cells from 2D segmented stacks - Nature Methods
u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, inc...
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Kevin Dean @kevin-dean.bsky.social · 07/11/2025
I am excited to see this resubmitted.
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