We analysed here the dynamic of the kinesin-like Pavarotti (Pav) during male gametogenesis of wild-type and Sas4 mutant flies. Pav localizes to the equatorial region and the inner central spindle of ....

Processing bodies (P-bodies) are cytoplasmic membrane-less organelles which host multiple mRNA processing events. While the fundamental principles of P-body organization are beginning to be elucidated...

Pericentromeric heterochromatin clusters into nuclear foci known as chromocenters, the proteome of which remains largely unknown. This study uses quantitative mass spectrometry to characterize the chr...

In some cases, non-genetic information can be inherited across generations. Fitz-James et al. investigate the mechanism by which such epigenetic information becomes heritable in fruit flies. They show...

Cell Research - AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae lethal phenotype of a fruit f...

Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

Summary: This study shows that heat shock increases glycogen synthase (GS) activity and levels. This study also shows that HSF1 regulates GS activation, and that GS is necessary for autophagy inductio...

Abstract. Host–pathogen infections and possible effects on co-evolutionary patterns depend on the genotypes of both host and pathogen. Obligate fungal path

An experimental evolution study on Drosophila sister species suggests that quantitative differences in cuticular hydrocarbons and in social structures shift across the generations to enhance sexual is...

Geographical, ethological, temporal and ecological barriers can affect interbreeding between populations deriving from an ancestral population, this progressively leading to speciation. A rare case of...

While genetic correlations can concentrate additive genetic variance into trait combinations that do not align with selection, genetic correlations themsel

Abstract. Mitochondrial function depends on the effective interactions between proteins and RNA encoded by the mitochondrial and nuclear genomes. Evidence

Studies on Drosophila BCAA-catabolism mutants reveal disrupted coordination between AMPK, PP2Ac, and mitochondrial function in brain tissues, uncovering a pivotal mechanism linking metabolic dysfuncti...

In neuronal dendrites of both rodents and flies, there are regularly spaced contact sites between the endoplasmic reticulum (ER) and plasma membrane, which function as hubs for regulating Ca2+ homeost...

Fasciclin 2 (Drosophila NCAM) is a homophilic Cell Adhesion Molecule expressed at moderate levels in the proliferating epithelial cells of imaginal discs, where it engages EGFR in a cell autonomous au...

The germline maintains unstable essential ribosomal DNA (rDNA) repeats to ensure each generation inherits a functional genome, yet it’s unclear how this activity is controlled. Here, the authors find ...

The selective elimination of inappropriate projections is essential for sculpting neural circuits during development. The class IV dendritic arborization (C4da) sensory neurons of Drosophila remodel t...

Rabah et al. discover an astrocyte-to-neuron hydrogen peroxide signalling cascade, which is crucial for long-term memory formation in Drosophila. This signalling is found to be inhibited by amyloid-β ...

Author summary The synaptonemal complex (SC) is essential for meiotic recombination and faithful chromosome segregation across eukaryotes, yet components of the SC are often poorly conserved. Here, we...

Author summary The spindle assembly checkpoint (SAC) is known to delay cell cycle progression until chromosomes are properly attached to microtubules. Meiotic cells often have modified cell cycle phas...

Xu et al. investigate how the speed of chromosome separation is regulated during the cleavage divisions of the Drosophila blastoderm. They find that spindle length and the cell cycle oscillator jointl...

Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.

Scientific Reports - Autoregulation of the glial gene reversed polarity in Drosophila