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Will Shaw

@willshaw.bsky.social
325 followers 198 following 17 posts

Postdoc in Mo Khalil’s lab at Boston University • synthetic biology • genome engineering • plants • yeast

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Reposted by Will Shaw
Mo Khalil @mokhalil.bsky.social · 17/07/2026
🌱🚨 Very proud and excited to share our PREPRINT, unveiling an advance for plant science, biotech, & synthetic biology in the first (of many) Khalil <> Gehring collaborations! www.biorxiv.org/content/10.6...
biorxiv.org
Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana
Agrobacterium -mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, ...
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Will Shaw @willshaw.bsky.social · 11/06/2026
New preprint out 🌱 We present a new T-DNA vector system for Arabidopsis that supports clean, genomically mapped, single-copy T-DNA insertion with predictable cell-type/conditional gene expression. @mokhalil.bsky.social + Gehring labs biorxiv.org/content/10.6... 🧵1/16
biorxiv.org
Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana
Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, u...
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Reposted by Will Shaw
Tom Ellis @proftomellis.bsky.social · 11/08/2025
New paper from our lab on synthetic genome work in yeast is out - Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes. Exciting project led by Jane (Xinyu) Lu in our group, now online. t.co/0LuGwgAWlA
t.co
https://www.nature.com/articles/s41467-025-62356-y
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Reposted by Will Shaw
Tom Ellis @proftomellis.bsky.social · 11/07/2025
Online now @ Cell is the yeast multicellular engineering paper from Fankang Meng - the fruits of his productive PhD in our group. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - specific adhesion, juxtacrine signalling and more. www.cell.com/cell/fulltex...
cell.com
Engineering yeast multicellular behaviors via synthetic adhesion and contact signaling
By designing synthetic toolkits for contact-based signaling (MARS) and cell-cell adhesion (SATURN), we program yeast to form multicellular structures and perform complex tasks, like building logic cir...
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Reposted by Will Shaw
Sarah Guiziou @sarah-guiziou.bsky.social · 15/04/2025
🚨 PhD project alert: Engineering a soil bacteria to sense and record soil health. 🦠 🪴 🥼 🧑‍💻 🌍 Fully funded PhD studenship in my group, open for international students. @earlhaminst.bsky.social Please share widely! Deadline: 14th of May www.earlham.ac.uk/studentship/...
earlham.ac.uk
Sentinel bacteria: engineering a soil bacteria to sense and record soil health
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Will Shaw @willshaw.bsky.social · 18/03/2025
Thrilled to share that I will be moving back to the UK later in the year to start my next chapter as a Career Development Fellow at the Earlham Institute! 🌱🧬
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Reposted by Will Shaw
Eric Topol @erictopol.bsky.social · 12/01/2025
Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging. Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social erictopol.substack.com/p/our-sleep-... open-access
erictopol.substack.com
Our Sleep, Brain Aging, and Waste Clearance
How sleep prevents "dirty" brains that age faster
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Reposted by Will Shaw
Satyaki PRV @satyakirv.bsky.social · 21/12/2024
Do you want an EMS-like drug that you can easily use in your lab or your garden shed to generate structural variation in your favorite plant? We show here that the topo2 inhibitor & common chemotherapy drug etoposide works really well to generate structural variation .
biorxiv.org
A simple method to efficiently generate structural variation in plants
Phenotypic variation is essential for the selection of new traits of interest. Structural variants, consisting of deletions, duplications, inversions, and translocations, have greater potential for ph...
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Reposted by Will Shaw
Mary Williams @PlantTeaching @plantteaching.bsky.social · 11/12/2024
Judge blocks rule that eased U.S. reviews of biotech crops Some plant researchers fear the setback could last years and will stifle innovation. (From Science) #PlantScience www.science.org/content/arti...
science.org
Judge blocks rule that eased U.S. reviews of biotech crops
Some plant researchers fear the setback could last years and will stifle innovation
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Reposted by Will Shaw
Tom Ellis @proftomellis.bsky.social · 08/12/2024
Latest preprint from Jane (Xinyu Lu) in our group explores what happens when we build a synthetic genome cluster in yeast for Histidine biosynthesis and SCRaMbLE it to see whether selected-for gene rearrangements can guide better design.
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