Rosetta Stone or Moby Dick?

ALT: a man in a kitchen with a sweater on that says oh no i am fine serenity now .

Howard et al. combine mechanistic deep mutational scanning, cryo-EM, and constant-pH molecular dynamics simulations to provide a holistic view of proton activation in human pH-sensitive GPCRs.

Structural and functional studies reveal how viral proteins trigger the phage antirestriction induced system (PARIS) to degrade host tRNA and how viral tRNAs suppress the PARIS nuclease and thereby ov...

Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining e...

Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antib...

Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...

The diffusion learning method, DiffDock, for docking small-molecule ligands into protein binding sites was recently introduced. Results included comparisons to more conventional docking approaches, wi...

Shi Zhengli, the virologist at centre of COVID lab-leak theory, reveals coronavirus sequences from Wuhan institute.

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I feel lucky to have gone through the Church Lab when I did, as I got to work with some really great people. While I was there, many of them left to become faculty elsewhere including  Gautam Dantas.....

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Assessing the influence of common mutations on rare disease risk.

Ramy Farid of Schrödinger maintains that AI drug discovery won't work unless physics-based calculations are part of the picture.

Waiting on Apple to add glucose tracking on a smartwatch to learn about your blood sugar? Don't. Try a biosensor instead.

Protein design has focused primarily on the design of ground states, ensuring they are sufficiently low energy to be highly populated. Designing the kinetics and dynamics of a system requires, in addi...