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Joe Peters Lab

@joepeterslab.bsky.social
1.3K followers 721 following 80 posts

Professor and Chair, Dept Microbiology Cornell Ithaca. Interested in genome evolution and mobile DNA, especially Tn7 and CRISPR-Cas transposition systems

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Joe Peters Lab @joepeterslab.bsky.social · 03/10/2025
The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...
cornell.wd1.myworkdayjobs.com
Technician III - Department of Microbiology
Position Summary This position will be in the lab of Dr. Joseph E. Peters in the Department of Microbiology. Research in the Peters’ lab broadly involves deciphering mechanisms in genome stability and...
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Joe Peters Lab @joepeterslab.bsky.social · 28/08/2025
De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems www.biorxiv.org/content/10.1...
biorxiv.org
De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems
Programmable DNA integration using CRISPR-associated transposons (CASTs) offers powerful capabilities for genome engineering. The single effector Cas12k CAST examples evolved from a fixed guide TnpB n...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 21/08/2025
The RecBCD complex interacts directly with the DNA sliding clamp in Escherichia coli www.biorxiv.org/content/10.1101/202…
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Joe Peters Lab @joepeterslab.bsky.social · 11/08/2025
Great to have former lab member Mike Petassi for a seminar with our Replication, Recombination, and Repair group! Presenting some of his postdoc work in the @dnacurtain.bsky.social lab. cals.cornell.edu/microbiology...
Mike Petassi presenting a slideMike Petassi eating lunch with the Joe Peters lab
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Cedric Feschotte @cedricfeschotte.bsky.social · 05/08/2025
Looking forward to this new installment of the Woods Hole Mobile DNA Meeting! Fantastic program, laid-back atmosphere, and gorgeous setting at the Marine Biological Laboratory ⛵️🪼🐋 Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...
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Joe Peters Lab @joepeterslab.bsky.social · 30/07/2025
Tn7 family transposons that include all of the guide RNA-directed transposons (CAST) are common in bacteria. We now find diverse representatives across archaea, with many in the Asgard group. Reviving an Asgard element confirmed the exciting behaviors of the family #MicroSky #TESky
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Joe Peters Lab @joepeterslab.bsky.social · 30/07/2025
Very excited about our work from @jordanthesier.bsky.social and @popomicro.bsky.social et al. We find that Tn7 family elements common in bacteria (that include all of the guide RNA-directed transposons, CAST) are also found across archaea including many in the exciting Asgard group! #MicroSky #TESky
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Joe Peters Lab @joepeterslab.bsky.social · 29/07/2025
Today is the last day to submit to be considered for a podium presentation at the EMBO transposon meeting this Fall. The organizers prioritized speaker slots sourced from submitted abstracts, we want to hear about your science!
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John Helmann @johnhelmann.bsky.social · 28/07/2025
Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field. #MicroSky #Metals rdcu.be/eycU2
rdcu.be
Microbial metal physiology: ions to ecosystems
Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...
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Josh Atkinson @electromicrobe.bsky.social · 17/06/2025
We're hiring! Do you have experience engineering yeast and using CRISPR? Jose Avalos and I are hiring a joint postdoc to work on an exciting fast-paced DARPA project with a great team at Neochromosome, Fermeate, and @joepeterslab.bsky.social puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu
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Joe Peters Lab @joepeterslab.bsky.social · 16/06/2025
Happy Transposon Day! 🧬➰🧬 Commemorating Barbara McClintock's birthday (June 16th, 1902-1992). #TransposonDay2025
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Joe Peters Lab @joepeterslab.bsky.social · 15/06/2025
Linking to #microsky #transposon
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Joe Peters Lab @joepeterslab.bsky.social · 15/06/2025
Exciting work from the Guarné lab indicating how the elusive TnsE pathway of prototypic Tn7 recognizes DNA replication features using an asymmetric dimer to integrate multiple signals at DNA replication forks linking target recognition to transposase recruitment doi.org/10.1093/nar/...
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Mark O. Martin @markowenmartin.bsky.social · 23/05/2025
First podcast recording of the day. Guest is Dr. Tory Hendry of Cornell University, chatting about interactions between fluorescent Pseudomonas and aphids!
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STCmicrobeblog @stcmicrobeblog.bsky.social · 29/03/2025
𝘢𝘧𝘪𝘤𝘪𝘰𝘯𝘢𝘥𝘢𝘴 & 𝘢𝘧𝘪𝘯𝘰𝘯𝘢𝘥𝘰𝘴 of chromosome ends (bacterial!) take note 👇 #MicroSky
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eric lai @lucksmith.bsky.social · 27/03/2025
wow, telomeric transposons in bacteria with linear chromosomes! (of course this was first figured out in flies, inc by Bob Levis, who i was happy to see few days ago at the fly meeting). 🪰 www.science.org/doi/10.1126/... www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...
science.org
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric tran...
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Joe Peters Lab @joepeterslab.bsky.social · 27/03/2025
A thread from the Postdoc who led the work on bacterial Telomeric transposons. A wonderful collaboration with the Barabas lab. Officially out in the journal today!
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George Ghanim @automnenine.bsky.social · 07/03/2025
Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch
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Joe Peters Lab @joepeterslab.bsky.social · 06/03/2025
Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...
science.org
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...
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Joe Peters Lab @joepeterslab.bsky.social · 06/03/2025
Our preprint is now published www.science.org/doi/10.1126/...
science.org
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...
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Joe Peters Lab @joepeterslab.bsky.social · 18/02/2025
Very excited about this work from graduate student Laura Chacon Machado now published in Mobile DNA, "A family of Tn7-like transposons evolved to target CRISPR repeats"! #TESky
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Carl Zimmer @carlzimmer.com · 17/02/2025
AIR-BORNE EXCERPT! Louis Pasteur climbed a glacier to hunt for floating germs. There he discovered a fundamental truth about all life. Here's the story, from my new book. [Gift link] Artwork by Antoine Maillard. 🧪 1/2 www.nytimes.com/2025/02/17/s...
A painting of Louis Pasteur with germs in the background, and a flask in the foreground showing him climbing a glacier.
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Joe Peters Lab @joepeterslab.bsky.social · 17/02/2025
I had the great pleasure of interacting with Bik Tye and her lab for many years at Cornell where she was one of the founding members of our DNA Replication, Recombination, and Repair (R3) group. It was wonderful to see this profile in PNAS www.pnas.org/doi/10.1073/...
pnas.org
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Stanley Maloy @blugenes.bsky.social · 29/01/2025
Want to learn more about genetic tools for studying bacteria and phage, check out the summer ABG Course at CSHL. This will be the 80th anniversary of the original CSHL Phage course, so you'll also meet many additional visiting genetics gurus! <https://meetings.cshl.edu/courses.aspx?course=C-ABG>
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Oded Rechavi @odedrechavi.bsky.social · 18/01/2025
If there's something we don't understand I assume transposons are responsible unless proven otherwise
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John Helmann @johnhelmann.bsky.social · 03/01/2025
Feeney also donated nearly 1 billion to Cornell Univ., which now has a street on campus named in his honor! news.cornell.edu/stories/2023...
news.cornell.edu
Chuck Feeney, Cornell’s ‘third founder,’ dies at 92 | Cornell Chronicle
Charles F. “Chuck” Feeney ’56, founding chairman of The Atlantic Philanthropies and Cornell University’s most generous donor, died Oct. 9 in San Francisco. He was 92.
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STCmicrobeblog @stcmicrobeblog.bsky.social · 18/12/2024
We strongly endorse the naming of 𝘚𝘵𝘳𝘦𝘱𝘵𝘰𝘮𝘺𝘤𝘦𝘴 𝘨𝘰𝘵𝘵𝘦𝘴𝘮𝘢𝘯𝘪𝘢𝘦 (DSM 3412) in honor of Susan Gottesman #MicroSky #microbiology
Susan Gotteman, workshop in Copenhagen DK, 2022 (photo Christoph Weigel)
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Leibniz Institute DSMZ @leibniz-dsmz.bsky.social · 09/12/2024
Honouring Esther Lederberg’s outstanding work on bacterial gene regulation, recombination and exchange, DSMZ researchers named the strain Streptomyces lederbergiae (DSM 44399) after her. #herstory #WomenInScience #microbiology #genetics
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Joe Peters Lab @joepeterslab.bsky.social · 06/12/2024
#MicroSky undergraduates! Please check out our summer REU opportunity!
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Joe Peters Lab @joepeterslab.bsky.social · 05/12/2024
Review on guide RNA-directed transposition (CAST) with an eye to functional genomics, "The promise of CRISPR-associated transposons for bacterial functional genomics" (Note JM Peters is not me or a relative, but is a friend and former coauthor!). #TEsky #MicroSky doi.org/10.1016/j.mi...
doi.org
Redirecting
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Ed Yong is offline @edyong209.bsky.social · 16/04/2018
A strange piece of mobile DNA, first discovered in clams, has spread itself throughout the oceans, jumping into the genomes of corals, fish, and more. Here's my piece on this shellfish gene. www.theatlantic.com/science/archive…
theatlantic.com
The Shellfish Gene
One strange piece of mobile DNA has spread itself through...
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Fromme Lab @fromme-lab.bsky.social · 04/12/2024
Excited to share the published version of our work by @ryanfeathers.bsky.social and @rvig.bsky.social on the structural basis for activation of Rab6 by the Ric1-Rgp1 complex! rdcu.be/d2mu3 Here is an updated thread about the paper we first shared on that older platform when we posted the preprint
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Melanie Blokesch @mblokesch.bsky.social · 25/11/2024
Exciting times! Our latest preprint is now live 🤩! After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n www.biorxiv.org/content/10.1...
biorxiv.org
Diverse phage defence systems define West African South American pandemic Vibrio cholerae
Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. Interestingly, two unique genetic signatures define the West ...
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Cell Chemical Biology @cp-cellchembiol.bsky.social · 21/11/2024
🔦 Spotlight! @ArturoCarabias & Guillermo Montoya (@g1_guillermo) highlight a recent study in @Nature by Rotem Sorek (@SorekLab) and colleagues describing 2 ways phages can reconstitute NAD+ to counter bacterial immunity dlvr.it/TGJtS8
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Ian Hewson @ianhewson.bsky.social · 21/11/2024
Took quite a while during the publication cycle but pleased to see this work out. Diadema mass mortality in the western Indian Ocean (Reunion) was at least associated with the same ciliate, DaScPc, as in the Caribbean, Arabian Gulf and Red Sea. esajournals.onlinelibrary.wiley.com/doi/10.1002/...
esajournals.onlinelibrary.wiley.com
Spread of a sea urchin disease to the Indian Ocean causes widespread mortalities—Evidence from Réunion Island
Click on the article title to read more.
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John Helmann @johnhelmann.bsky.social · 21/11/2024
How do secreted and membrane-localized enzymes get appropriately metalated? ... Bixi He and I tackled this question, with a focus on the cell envelope... Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis | Annual Reviews - go.shr.lc/3V0lM92
go.shr.lc
Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis | Annual Reviews
Cell physiology requires innumerable metalloenzymes supported by the selective import of metal ions. Within the crowded cytosol, most enzymes acquire their cognate cofactors from a buffered labile poo...
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Anupama Khare @anukharelab.bsky.social · 18/11/2024
Check out this new review from our lab led by postdoc Pavan Silva! We explore the varied mechanisms by which gene amplifications lead to antibiotic resistance. www.nature.com/articles/s44...
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Heather Feaga @heatherfeaga.bsky.social · 17/11/2024
First ever post here is our work now out in mBio! We show that E. coli is a WEIRDO for not using the RQC pathway to rescue its non-stop ribosomes. Given the chance, E. coli can use this pathway and it rescues the lethality of deleting ArfA and trans-translation! journals.asm.org/doi/10.1128/...
journals.asm.org
The ribosome-associated quality control pathway supports survival in the absence of non-stop ribosome rescue factors | mBio
In bacteria, it is estimated that 2%–4% of all translation reactions terminate with the ribosome stalled on a damaged mRNA lacking a stop codon. Mechanisms that rescue these ribosomes are essential for viability. We determined the functional overlap ...
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Heran Darwin, PhD @heran.bsky.social · 17/11/2024
Application deadline has been extended to January 10, 2025...
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Joe Peters Lab @joepeterslab.bsky.social · 16/11/2024
Please consider attending the 2025 ASM Microbe meeting! I will be talking about Tn7 and Tn7-like elements as a "Track Hub" talk and it would be great to see you there! asm.org/events/asm-m...
asm.org
ASM Microbe | Abstracts
ASM Microbe 2025 showcases the best microbial sciences in the world and provides a one-of-a-kind forum to explore everything from basic microbiology to translation and application.
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Joe Peters Lab @joepeterslab.bsky.social · 15/11/2024
Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear chromosomes and plasmids. We identified several families of independently evolved telomeric transposons in cyanobacteria and Streptomyces. 1/7 www.biorxiv.org/content/10.1...
biorxiv.org
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. While many bacteria also have linear chromosomes and plasmids, no trans...
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Deborah Bourc’his @deborahbourchis.bsky.social · 14/11/2024
Thrilled to announce that the EMBO workshop «Mobile Genome» will be back in Heidelberg, Nov 4-7th 2025 @EMBLEvents @EMBO. Registration open soon but you can already register interest. Organized with fantastic colleagues @juliusbrennecke @GonzalezLab_BCN @JoePetersLab www.embl.org/about/info/c...
embl.org
The mobile genome: genetic and physiological impacts of transposable elements
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João Botelho @joaoftsbotelho.bsky.social · 10/11/2024
Mobile Elements Starter Pack on BlueSky! Interested in plasmids, phages, ICEs, transposons, integrons, and all things accessory genome? Follow this curated list of researchers and labs doing exciting work in mobile elements.
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Joe Peters Lab @joepeterslab.bsky.social · 26/10/2024
Recent work from the lab from graduate student Laura Chacon Machado describing a family of Tn7-like transposons that evolved to target CRISPR repeats now on bioRxiv 1/n www.biorxiv.org/content/10.1...
biorxiv.org
A family of Tn7-like transposons evolved to target CRISPR repeats
Tn7 family transposons are mobile genetic elements known for precise target site selection, with some co-opting CRISPR-Cas systems for RNA-guided transposition. We identified a novel group of Tn7-like...
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Joe Peters Lab @joepeterslab.bsky.social · 11/08/2024
Very excited that this collaborative project is now published. This work was championed by Dr. Yu Tang(Tongji University School of Medicine) and started during a visit to my lab. doi.org/10.1093/nar/...
doi.org
Transposition with Tn3-family elements occurs through interaction with the host β-sliding clamp processivity factor
Abstract. Tn3 family transposons are a widespread group of replicative transposons, notorious for contributing to the dissemination of antibiotic resistanc
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Ian Hewson @ianhewson.bsky.social · 29/02/2024
The Department of Microbiology at Cornell is searching for a new teaching position in Ethics of the Life Sciences. This exciting new opportunity will cross life sciences disciplines in the College of Agriculture and Life Sciences. tiny.cc/Lecturer_in_...
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Joe Peters Lab @joepeterslab.bsky.social · 26/02/2024
This story involved many hands over many years. Novel mechanisms of diversity generation in Acinetobacter baumannii resistance islands driven by Tn7-like elements academic.oup.com/nar/advance-...
academic.oup.com
Novel mechanisms of diversity generation in Acinetobacter baumannii resistance islands driven by Tn7-like elements
Abstract. Mobile genetic elements play an important role in the acquisition of antibiotic and biocide resistance, especially through the formation of resistance
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Joe Peters Lab @joepeterslab.bsky.social · 17/02/2024
I am so grateful for my nominators and the Academy for this great honor. My academic work has been enriched in countless ways from my many different interactions with ASM over the years making this especially meaningful to me. asm.org/Press-Releas...
asm.org
65 Fellows Elected into American Academy of Microbiology
In Feb., the American Academy of Microbiology elected 65 new fellows to the Class of 2024.
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Joe Peters Lab @joepeterslab.bsky.social · 28/12/2023
So great to have a visit from former PhD student Mike Petassi. Also allowed us to celebrate the 3 year anniversary of his exciting first CAST paper this month with co-author Shan-Chi (Popo) Hsieh
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Ákos T Kovács @evolvedbiofilm.bsky.social · 01/12/2023
I have a text that I usually use in my reply:. I do not contribute or review for MDPI, among the various reasons, see for example: blogs.lse.ac.uk/impactofsoci... racism: forbetterscience.com/2020/12/29/m... [1/2]
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