iiinova — where your digital self keeps evolving

Sebastian S. Cocioba @atinygreencell.bsky.social · 2h

FYI a public bug reporter 8 days ago in @biorxivpreprint.bsky.social breaks API calls for abstracts. Im making a news and weather app that also scapres bioarchive latest preprints and been fighting a bug i thought was internal. Just a heads up to anyone building preprint scrapers.

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Reposted by Sebastian S. Cocioba

Dr Darren Abbey @thebiologistisn.bsky.social · 22h

My lima bean harvest for the day. The later harvested magenta type in the middle look more of a lavender tone. A few pods had distinctly brighter seeds. I'll compare these to earlier harvested seeds from the same type.

Lima beans sorted by color. At the top is a pile of bright yellow seeds. In the middle is a pile of lavender seeds. At the bottom are two small piles of brighter magenta-red seeds.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 01/10/2026

Sweeeet! SpliceCraft is now an official Claude Skill which you can enable anytime as of today. I hope this is of service and I welcome any feedback. Thanks for considering my tools for your labors. I'll be supporting this software for a long long time since I use it daily.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 29/09/2026

I made SpliceCraft a Claude Skill! Waiting on the manual review but should be live real soon. For anyone not using Claude, I made agent side-doors that give agents full access to all the functions of SpliceCraft directly. Powerful cloning tool, deeply vetted, and made with love💚

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Sebastian S. Cocioba @atinygreencell.bsky.social · 26/09/2026

Feeling proud of where SpliceCraft is at right now. Still got more details to add and UI jank to solve, but powerful af and open source. Made, with love, for this community. Enjoy. SpliceCraft.bio

splicecraft.bio

SpliceCraft — the in-terminal plasmid workbench

Design, clone & mutate plasmids in a mouse-friendly terminal workbench. Everything runs on your own computer — no cloud, no account.

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Reposted by Sebastian S. Cocioba

Robert Reich @rbreich.bsky.social · 25/09/2026

DoorDash spent $1.4M trying to stop Zohran Mamdani from becoming mayor. This week's historic $131.5M enforcement action against DoorDash for underpaying NYC delivery workers shows why. Yet another reminder that the only thing that can beat organized money is organized people.

theintercept.com

DoorDash Spent $1.4 Million Trying to Stop Mamdani From Becoming Mayor. Now We Know Why.

In a wage-theft settlement, DoorDash now has to pay its workers around 100 times what it spent trying to beat Zohran Mam

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Sebastian S. Cocioba @atinygreencell.bsky.social · 26/09/2026

I thank microbiology for allowing me to modify plants, assemble DNA, express proteins, study catabolism, and show the world the endless gifts and bounties of our oceans. Microbio is the foundation of modern bioengineering regardless of the clade you study in. Highly rec. 10/10

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Sebastian S. Cocioba @atinygreencell.bsky.social · 25/09/2026

IPTG >>> ChatGPT More wetlab for everyone!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 25/09/2026

Science twitter is big mad at the latest anthropic claim and the Ai bros just revealed how thin skinned they are. Welcome to peer review, lol.

static.klipy.com

Michael Jackson Eating Popcorn at the Movies

ALT: Michael Jackson Eating Popcorn at the Movies

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Sebastian S. Cocioba @atinygreencell.bsky.social · 22/09/2026

Fly, my pretties! Fly! So far so good and no downgrade to opus 5.1. Seeing the full agent swarm is a good sign. Also caught some convenient possible mixups with linear plasmids. That was on my todo list but never implemented!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 22/09/2026

Let's see what Opus 5.5 can do. Throwing it at SpliceCraft for a full codebase review. My codebase is deeply hardened and robust af, so anything caught could either be marginal improvements or substantial bug and nothing in between. Will report back!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 19/09/2026

First agroinfiltration of RUBY into Campanula carpatica, maybe ever? Let's see if my go-to ubiquitin promoter circuit works in this clade. 🤞🔔🌺

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Reposted by Sebastian S. Cocioba

August Pamplona @cosmicaug.bsky.social · 19/09/2026

@atinygreencell.bsky.social, I'm guessing that you are familiar with all of this already?

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Sebastian S. Cocioba @atinygreencell.bsky.social · 18/09/2026

Everything in my life rn is wildly difficult and the hard hits keep bouncing off the old armor, but every single day I get to be the person I built from scratch, that carved a career in flower design I am proud of. What a privilege to tinker alongside the star sippers every day!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 18/09/2026

First seeds! The parent I got from a local grower had some dry buds. At first I thought they were too small to be viable but cracked one anyway and lo there be seed. Also a few green buds that are very gravid so ample stocks for later. Gonna start these if I feel better later. 👨🏻‍🌾

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Sebastian S. Cocioba @atinygreencell.bsky.social · 18/09/2026

Callin out of work today on account of my dumb spine nerves and their dumb debilitating inflammation. Gonna hobble over to the incubator to check on my plates and call it a day. Back's a biological barometer and it be rainin so I be painin. Take care of you spine, kiddos. ❤️‍🩹

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Sebastian S. Cocioba @atinygreencell.bsky.social · 18/09/2026

I love getting to know a plant. First step on my list is always "can it self pollinate?". This one is important because I can descend ideal traits and stabilize wonky ones. Feels good to start fresh.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 17/09/2026

New adventure in carpathian bellflower. Excited to carve out some deeply understudied ground. It's beautiful in strange ways and stubborn in all ways, just how I like them.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 17/09/2026

Look, the damn poo bugs only need to grow overnight, okay? A thimble of media is ample...

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Sebastian S. Cocioba @atinygreencell.bsky.social · 12/09/2026

Finally found my first legendary gene in my microbial roguelike!!! This one adds a flagella to the playable character and adds a multi-tile dash to evade hostile microbes. Not too much ATP drain but still need to level up to meet its metabolic burden. I love making this game!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 08/09/2026

My Alice petunia explants already undergoing shoot organogenesis after just 13 days from plating leaf disks. So fast!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 04/09/2026

This new culture of attribution-less egoism is getting out of hand. Luckily for me you actually need to know what the fuck you're doing to make good software for biology. All I ask for is a shoutout. Seems everything I work on these days gets aped, lolol www.instagram.com/reel/Dcy0kZp...

instagram.com

Instagram

Create an account or log in to Instagram - Share what you're into with the people who get you.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 02/09/2026

The greatest science communication in the history of biochemistry. Please share with your students. Let them hum the glorious battle hymn during exams. youtu.be/BCAUaYpbHwY?...

youtu.be

Mass Effect 3: Citadel - Mordin Solus Amino Acids Song

YouTube video by thepalgi

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Sebastian S. Cocioba @atinygreencell.bsky.social · 28/08/2026

Corn is at 57% good to excellent quality, 14 points lower than last year. Guys, I know Ai is cool and making money is apparently the most important thing above all else, but we can't just eat dollars. Might be a good time to get into revamping our very fragile agriculture...

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Sebastian S. Cocioba @atinygreencell.bsky.social · 27/08/2026

Last night I added some flavor text for the genes you can loot in my microbial roguelike game. Here's the nobel lecture from 1988 on solving the structure of photosystem protein psbA: www.nobelprize.org/prizes/chemi... Game link here (still very rough): binomica-labs.github.io/Microgue/

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Sebastian S. Cocioba @atinygreencell.bsky.social · 27/08/2026

Finally got a break from the endless spine pain to do more petunia experiments. This is now the fully F8 inbred version of my Alice petunia that I have been breeding since 2021. I selected for regeneration speed, transformability, and big big flowers.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 25/08/2026

Feelin vindicated lol journals.asm.org/doi/10.1128/...

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Reposted by Sebastian S. Cocioba

Elinne Becket, PhD @bielleogy.bsky.social · 21/08/2026

I believe the nanodrop is unfairly maligned and in many cases complaints are from user error *ducks and hides*

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Sebastian S. Cocioba @atinygreencell.bsky.social · 20/08/2026

Evolution is the coolest Two meters of sugar-phosphate chain crammed into a 6 micron nucleus, spooled around tailed hockey pucks, all thanks to arginines wedged into the minor groove doing the gripping and lysine tails acetylated to let go. Biology is the greatest show on Earth

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Sebastian S. Cocioba @atinygreencell.bsky.social · 20/08/2026

Giving a small lecture to my team tomorrow on plant epigenetics and it's reminding me of how much I love the winding and unwinding of DNA. It's a great example of how physical the molecular world can be, and how effective thread analogies are when explaining gene expression. 🧵🧬

static.klipy.com

Hercules: The Fates Cut the Thread of Life

ALT: Hercules: The Fates Cut the Thread of Life

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Sebastian S. Cocioba @atinygreencell.bsky.social · 19/08/2026

Yay, @plasmidsaurus.bsky.social was kind enough to run shotgun metagenomics on my duckweed biofilm sample! They also have a cool functional pathways tab in the UI to see what metabolics are most prevalent. Here is the data if anyone is curious; FASTQ included! drive.google.com/drive/folder...

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Sebastian S. Cocioba @atinygreencell.bsky.social · 16/08/2026

You know you've made it when microbes start following you.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 16/08/2026

Ribbed mussels anchor to cordgrass stems and poop plankton-derived nitrogen into the peat. Their mounds store freshwater and flush toxic sulfide. The grass repays them with shade, anchorage, and cover from crabs. Cordgrass survives drought 5x-25× better where mussels pile up 🦪🌾

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Sebastian S. Cocioba @atinygreencell.bsky.social · 13/08/2026

Phew, it's been a rough summer for me health-wise but I am making progress. Chronic pain is a unique hell to navigate while also trying to be a full person, caring partner, and practicin bioengineer. Cherish and enjoy your painfree world; it's so precious. Solidarity otherwise ❤️‍🩹

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Reposted by Sebastian S. Cocioba

Elinne Becket, PhD @bielleogy.bsky.social · 11/08/2026

The comment thread feels like ol' SciTwitter again 🥰😆

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Sebastian S. Cocioba @atinygreencell.bsky.social · 07/08/2026

RESULTS ARE COOL!!! Piscinibacter gummiphilus seems the major species but less confident in read quality. If anyone wants to have a peek at what species are growing in my duckweed tank, here are the results as a zip file straight from @plasmidsaurus. Enjoyyyy! drive.google.com/drive/folder...

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Sebastian S. Cocioba @atinygreencell.bsky.social · 05/08/2026

Bringing a transgenic ornamental to market continues to be an extreme challenge but I am so proud of my team for developin some truly beautiful plants. I am so eager to share how they look like and we hope to be able to do so soon. The USDA has been amazingly helpful in all this!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 05/08/2026

A lil traditional cloning this afternoon, working with some legacy plasmids so no golden braid this time.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 04/08/2026

Sheesh, petunia is gettin a little crowded. Might pivot to something else at this rate. Feels weird; might revisit the carpathian bellflower and/or foxglove. Let's see how long until that gets crowded too lol. Gotta love inspiration..

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Sebastian S. Cocioba @atinygreencell.bsky.social · 02/08/2026

Sample of whatever tf is growing in my duckweed containers has been collected and pickled in Zymo Research's Zymo Shield. Ready to ship to @plasmidsaurus.bsky.social for microbiome analysis tomorrow morning. $45 for seq and $15 for extraction. $75 with shipping and everything. Exciting!

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Sebastian S. Cocioba @atinygreencell.bsky.social · 31/07/2026

Off to Chicago to tour Ball Horticultural and give a talk on all the cool stuff we're up to at Neoplants! Excited to talk flower design, Ai driven morphological exploration, and the deeply universal desire to bring beauty to this world by learning from nature. Let there be flowers.

static.klipy.com

Shiba Inu Gently Pets a Flower

ALT: Shiba Inu Gently Pets a Flower

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Sebastian S. Cocioba @atinygreencell.bsky.social · 30/07/2026

Bioengineering is just so cool. Poking at a cold fire that's been burning for billions of years, trying to get it to burn in a particular way, is nothing short of real practical magic.

static.klipy.com

Cozy Campfire in Dark Woods

ALT: Cozy Campfire in Dark Woods

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Botanical Society of America @botsocamerica.bsky.social · 27/07/2026

🌱SPECIAL ISSUE CALL FOR PAPERS🌱 #AppsPlantSci is accepting proposals for a special issue highlighting video & imaging techniques that are driving novel research in plant science Proposal deadline: 5 Oct 2026 More info: bit.ly/4c3rLCw @noraflora10.bsky.social @drfloeem.bsky.social #botany

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Sebastian S. Cocioba @atinygreencell.bsky.social · 28/07/2026

I repurposed my old Samsung S10+ as a duckweed growth monitoring server without any extra hardware. All processing done via termux on the phone. Thank you Claude for the from-scratch blob detection bc no termux OpenCV packages available. Needs work but not bad for a oneshot!

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