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Lis Lowe

@lislowe.bsky.social
1.4K followers 772 following 118 posts

Scientist, mum, wife. Fan of gut bacteria, mycobacteria, glycans and cazymes. Mannose evangelist. Lowe Lab, NUBI, Newcastle University

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Reposted by Lis Lowe
James Connolly @ruamicro.bsky.social · 14/09/2026
Are you a motivated researcher interested in bacteria-host interactions? We have postdoc position available in my lab to join our Wellcome Trust funded collaborative team. We will study the role and regulation of the enigmatic sphingolipids in E. coli. Please share. www.jobs.ac.uk/job/DSX115/r...
jobs.ac.uk
Research Assistant/ Associate in Bacteria-Host Interactions at Newcastle University
Explore an exciting academic career as a Research Assistant/ Associate in Bacteria-Host Interactions. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
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Edward Wallace @ewjwallace.bsky.social · 19/08/2026
Postdoctoral position available! Help us to understand how fungi cause disease, by bringing data-driven engineering biology and cool fluorescent protein tools into fungal pathogens. Details: ewallace.github.io/news/postdoc... Please share!
ewallace.github.io
Postdoctoral position in fungal engineering biology
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bioRxivpreprint @biorxivpreprint.bsky.social · 15/08/2026
Functional Differentiation of GH172 Arabinofuranosidases Through Divergent Quaternary Structures www.biorxiv.org/content/10.64898/20…
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Jamie Blaza @jnb-lab.bsky.social · 15/08/2026
We’ve got a set of related but divergently assembled enzymes, activity based probes, and a really high res cryoEM structure! Brilliant working with Jenn and Lis and hopefully the first of many papers 😀
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Lis Lowe @lislowe.bsky.social · 15/08/2026
New preprint out - Jenn’s hard work over the last few years collaborating with @jnb-lab.bsky.social, Overkleeft Lab in Leiden, Spencer Williams, Hannah Bridges at Cryosparc and @pmoyniha.bsky.social. Feat. her beautiful 1.5A cryo structure with a covalent inhibitor 😍. www.biorxiv.org/content/10.6...
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Kate Beckham @kshbeckham.bsky.social · 03/08/2026
Happy to share our recent story on the Type VII secretion system. Here were present new insights into the regulation of secretion mediated by the central pore. Thanks to all authors involved in the work. 🙂
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Georgia Isom @georgiaisom.bsky.social · 10/07/2026
Interested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria. The deadline is 31st July. Informal enquires are welcome. Please share!
my.corehr.com
Job Details
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Typas Lab @typaslab.bsky.social · 29/06/2026
How can we harness the vast functional diversity of microbes on our planet? Join us at EMBL Heidelberg from 8–10 December 2026 to hear about ongoing efforts to decode gene function and organisation in human gut microbes, and to present your own research. www.embl.org/about/info/c...
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Lis Lowe @lislowe.bsky.social · 25/06/2026
Out after a lot of hard work from many people. When we first found arabinanase enzymes in mycobacteria we started looking into their roles in cell remodelling & pathogenesis. Did not expect to find that some species had weaponised them to kill competitors! Myco are endlessly surprising. #glycotime
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Patrick Moynihan @pmoyniha.bsky.social · 24/06/2026
New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
nature.com
A Type VII-secreted toxin enables inter-mycobacterial competition - Nature Communications
Mycobacteria have not yet been reported to engage in interbacterial competition via secretion of proteinaceous toxins. Here, Benedict et al. show that some mycobacteria can use their type-VII secretio...
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Alan Cartmell @acartmell47.bsky.social · 27/05/2026
Happy to have this collaborative work with Zach Armstrong now out in Angewandte chemie doi.org/10.1002/anie... . We use a linked assay, coupled with fluorescent probes, to analyse mucin active carbohydrate sulfatase kinetics, cellular location, and inhibition.
doi.org
Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases
We report plate-based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin-active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor ide...
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Zach Armstrong @armstrongchembio.bsky.social · 08/06/2026
I'm excited that this collaborative work with Alan @acartmell47.bsky.social is finally out. We have developed some powerful tools to study carbohydrate sulfatases (a tricky class of enzyme!) and shown how they can be used with enzymes from host-associated bacteria.
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Vivek Nityananda @viveknityananda.bsky.social · 05/06/2026
Funny how absence can tell its own story. Seeing the university display the Pride flag right opposite my window was heartwarming every June. It's been two years now without it. Sign of the times I guess.. 🏳️‍🌈
Flagpost in the sun with no flag on it
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Lis Lowe @lislowe.bsky.social · 15/05/2026
First paper for PhD student in the Bolam / Lowe labs Natalia Łoś on a the characterisation of a new CBM family that binds (beta) mannan! #glycotime @natalia-los.bsky.social 🥳🥳 link.springer.com/article/10.1...
link.springer.com
Unusual molecular architecture of a human gut microbiota β-mannanase reveals a new CBM family - Cellular and Molecular Life Sciences
β-mannans are plant structural and storage polysaccharides prevalent in the human diet. Their degradation in the gastrointestinal tract is mediated by the human gut microbiota (HGM) through expression...
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Lis Lowe @lislowe.bsky.social · 14/05/2026
Time for @kateduncan.bsky.social to talk about chemistry and why microbes use it via some interactive questions
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Dr Katherine Duncan @kateduncan.bsky.social · 14/05/2026
We start of the ‘2026 Celebration of Microbiology’ event @newcastleuni.bsky.social @medicalsciencesncl.bsky.social organised by PhD and Postdoc reps from @mhd-newcastle.bsky.social @cbcb-newcastle.bsky.social Chloe, Natalia, Rachel and Jean-Lou
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Augustinas Silale @augustsilale.bsky.social · 02/05/2026
Our study on Bacteroides iron piracy is now out in @pnas.org. We show how surface-exposed lipoproteins bind xenosiderophores with different iron-chelating chemistries and propose a mechanism for xenosiderophore import across the outer membrane. Lots of structures (mostly X-ray this time)!
doi.org
Structural basis of iron piracy by human gut Bacteroides | PNAS
Iron is an essential element that can be growth-limiting in microbial communities, particularly those present within host organisms. To acquire iro...
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Lis Lowe @lislowe.bsky.social · 29/04/2026
We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...
findaphd.com
Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University on FindAPhD.com
PhD Project - Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University, listed on FindAPhD.com
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MichaelMcMurray lab @mcmurraylab.bsky.social · 22/04/2026
Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic
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Simon Hammann @simonhammann.bsky.social · 20/04/2026
Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.
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Dr Katherine Duncan @kateduncan.bsky.social · 16/04/2026
Wonderful to have @pmoyniha.bsky.social from Western University, Canada (hosted by @lislowe.bsky.social) giving a @mhd-newcastle.bsky.social seminar @medicalsciencesncl.bsky.social @newcastleuni.bsky.social #mycobacterium #tb #cellwalls
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Sam Benedict @sambenedict5.bsky.social · 27/03/2026
Unbelievably proud of the work that everyone has put into this paper. Really grateful for such fab colleagues! Mycobacteria continue to be (subjectively) the most interesting bacteria 🤭
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Kate Beckham @kshbeckham.bsky.social · 27/03/2026
Very cool to see Type VII toxins involved in competition. Even more exciting avenues for the T7SS field!
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Tracy Palmer @proftracypalmer.bsky.social · 27/03/2026
And a big shout out to Kieran Bowran whose bioinformatics analysis suggests there are multiple toxins out there
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Patrick Moynihan @pmoyniha.bsky.social · 27/03/2026
We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Lis Lowe @lislowe.bsky.social · 27/03/2026
We’ve been sciencing! M abscessus makes a arabinanase toxin to chop up the cell wall of competitor mycobacteria! #glycotime 🦠 thanks to @wellcometrust.bsky.social for the funding that makes this collaborative work possible! Also Sam’s structures are 😍 and Jean-Lou did some lovely biochem
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Typas Lab @typaslab.bsky.social · 12/03/2026
How can we tap into the enormous functional diversity of microbes on this planet? Join us at EMBL Heidelberg (8–10 Dec 2026) to learn about ongoing efforts to decode gene function and organisation in human gut microbes, and present your science.
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Addgene @addgene.bsky.social · 06/03/2026
Plasmids are available now! "A universal protein ladder for standardisation of diverse FRET assays" www.addgene.org/browse/artic...
addgene.org
Addgene: A universal protein ladder for standardisation of diverse FRET assays
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Sabina Leanti La Rosa @sabinallarosa.bsky.social · 25/02/2026
PhD position available in our lab at NMBU in 🇳🇴 with focus on proteomics, enzyme discovery, applied enzymology and a touch of microbiology🐟🧪🧬💻🦠 Deadline for applying: April 04, 2026. RTs highly appreciated. For details, see the link below 👇 www.jobbnorge.no/en/available...
jobbnorge.no
PhD scholarship within biotechnology (296538) | Norwegian University of Life Sciences (NMBU)
Job title: PhD scholarship within biotechnology (296538), Employer: Norwegian University of Life Sciences (NMBU), Deadline: Friday, April 3, 2026
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Syma Khalid @sykhalid.bsky.social · 02/02/2026
A gift of an article from the inimitable Colin Kleanthous as he says a moving farewell to his laboratory. A brave, unrepentant and scientifically brilliant journey is described - please have a read, friends. www.jbc.org/article/S002...
jbc.org
Bacteriocin biophysics: From protein-protein interaction models to navigators of the bacterial cell envelope
Bacteriocins are toxins deployed by bacteria to kill their competitors. Here, I reflect on my laboratory’s work on protein bacteriocins and their immunity proteins from Gram-negative bacteria. We unco...
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Nature Communications @natcomms.nature.com · 02/02/2026
#Microbiology The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear Here the authors clarify how bedaquiline works @jnblab.bsky.social @morwan.me #TBSky #antibiotics #AMR dlvr.it/TQjZ0W
Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.
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Rob Fagan @robfagan.bsky.social · 02/02/2026
I know what they're getting at with the "could put jobs at risk" but can we focus on the immediate impact? Each suspended round at MRC and BBSRC means about 80 fewer postdoc jobs and the retrospective cuts at MRC add another 30 or so
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AskAubry 🦝 🐆 @ask-aubry.com · 30/01/2026
With much love RIP Catherine O'Hara.
TAKE A THOUSAND NAKED PICTURES OF YOURSELF NOW. YOU MAY CURRENTLY THINK, "ON I'M TOO SPOOKY OR "NORODY WANTS TO SEE THESE TINY BOOBIES" BUT BEUEVE ME ONE DAY YOU WILL LOOK AT THOSE PICTURES WITH MUCH KINDER EYES AND SAY "DEAR GOD, I WAS A BEAUTIFUL THING!

MORA ROSE
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Ben Schulz @benschulz.bsky.social · 29/01/2026
Hudson Freeze #glycotime www.theguardian.com/us-news/vide...
A partially frozen Hudson River
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Ali Twelvetrees @dozenoaks.bsky.social · 28/01/2026
I am completely baffled by the total lack of any action or any evidence of speaking out from our scientific ‘leaders’. We’re in a void of information and the consequences are potentially catastrophic- especially as it looks like BBSRC are following suit.
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Tracy Palmer @proftracypalmer.bsky.social · 23/01/2026
www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
findaphd.com
Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com
PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com
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Hall Lab @halllab.bsky.social · 07/01/2026
Happy New Year – new role! 🎉 We’re looking for a PostDoc to join us in @halllab.bsky.social @unibirmingham.bsky.social. Full-time, fixed-term to March 2028. Note tight closing date: 11 Jan 2026. CV + cover letter (submit via portal). Further details 👇 edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
edzz.fa.em3.oraclecloud.com
Research Fellow - Department of Microbes, Infection and Microbiomes - 106849 - Grade 7
To create and contribute to the creation of knowledge by undertaking a specified range of activities as part of an Investigator project funded by Wellcome, focusing on understanding microbial and diet...
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Luiz Pedro Carvalho, PhD @luizcarvalholab.bsky.social · 22/12/2025
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.
nature.com
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
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Dr Katherine Duncan @kateduncan.bsky.social · 02/12/2025
Fantastic to have Prof Matthias Wilmanns from EMBL Hamburg hosted by @kshbeckham.bsky.social to give a @mhd-newcastle.bsky.social seminar on mycobacterial infection #dreamtheme
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Vivek Nityananda @viveknityananda.bsky.social · 18/11/2025
Absolutely blown away by the staging and acting at opening night of my play @taratheatre.com last night. Thanks so @natashakchandra.bsky.social and the entire team for transforming it into something special! Please go see it if you're in London- on until Nov 29th: taratheatre.com/whats-on/i-d...
taratheatre.com
I Dream of Theresa May – Tara Theatre
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Ariane Briegel @arianebriegel.bsky.social · 18/11/2025
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
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Vivek Nityananda @viveknityananda.bsky.social · 13/11/2025
I wrote about my play and where it came from for @qxmagazine.bsky.social : www.qxmagazine.com/2025/11/i-dr...
qxmagazine.com
I Dream Of Theresa May: Vivek Nityananda writes about his new play at Tara Theatre, 17 - 29 November 2025
I Dream Of Theresa May: Vivek Nityananda writes about his new play at Tara Theatre, which runs from 17 - 29 November 2025.
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Jon Marles-Wright @jmarlesw.bsky.social · 13/11/2025
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
An illustration of a carbonic anhydrase complex in a synthetic mini-carboxysome
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Emma Scott @dremmascott.bsky.social · 11/11/2025
Funded PhD opportunity for anyone interested in using cutting-edge chemistry to look at glycan profiles in prostate cancer samples 🙌🏻 The successful student will be based at the University of York with Prof Alison Parkin with the opportunity to carry out a placement at the @nucancer.bsky.social
eur03.safelinks.protection.outlook.com
MRC DiMeN Doctoral Training Partnership: Rapid and sensitive diagnostic ‘fingerprinting’ of prostate cancer O-glycans using Fourier-Transform alternative current voltammetry (FTACV) at University of Y...
PhD Project - MRC DiMeN Doctoral Training Partnership: Rapid and sensitive diagnostic ‘fingerprinting’ of prostate cancer O-glycans using Fourier-Transform alternative current voltammetry ...
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Typas Lab @typaslab.bsky.social · 13/10/2025
Excited to share our preprint led by Carlos Voogdt et al We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera. www.biorxiv.org/content/10.1...
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Lis Lowe @lislowe.bsky.social · 29/09/2025
Spending some time collecting memories of Harry today 🥺 - this is when he was elected a Fellow of the Royal Society. If anyone in the #glycotime universe has pictures or memories of Harry Gilbert they want to share please send them my way 💚
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 23/09/2025
Next up, Dr Kate Beckham @kshbeckham.bsky.social The Beckham lab is interested mycobacterial membrane transport processes. They focusing on understanding the steps occurring at the mycobacterial outer membrane. www.ncl.ac.uk/cbcb/staff/p...
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 23/09/2025
Day 2 of MHD introductions 😃 Dr Lis Lowe @lislowe.bsky.social The Lowe lab is focussed on microbial glycobiology. They work on bacterial Cazymes from commensals and pathogens, and are particularly interested in enzymes that target microbial glycans such as the cell walls of Mycobacteria.
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James Connolly @ruamicro.bsky.social · 30/07/2025
Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.
nature.com
Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens - Nature Communications
Cottam et al. identify distinct pathways for D-ribulose utilisation in pathogenic Escherichia coli and Citrobacter rodentium, providing mechanistic details and suggesting convergent evolution towards ...
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Dr Katherine Duncan @kateduncan.bsky.social · 22/07/2025
*JOB AD*: interested in doing a postdoc in microbial metabolomics? Passionate about natural products mass spec? Come join the group! Informal enquires welcome! Closing Date: 19 August 2025 jobs.ncl.ac.uk/job/Newcastl...
jobs.ncl.ac.uk
Research Associate - Microbial Metabolomic
Research Associate - Microbial Metabolomic
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