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Arthur Charles-Orszag

@acharlesorszag.bsky.social
745 followers 1.3K following 72 posts

Assistant Professor at UC Davis. Cell biologist interested in archaea and evolution. UCSF & Institut Pasteur alum. He/him 🇫🇷 🏳️‍🌈 www.charlesorszaglab.com

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Arthur Charles-Orszag @acharlesorszag.bsky.social · 14/09/2026
@spearmicrobe.bsky.social, me and our land yacht at Mud Caldron 🔥 🧖🏻
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 14/09/2026
Andy and I finally got to see Yellowstone! Pictured here are Grand Prismatic and the legendary Mushroom Spring (Taq)
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 03/08/2026
The lab CryoCube freezer’s alarm has been a little temperamental lately, so the undergrads renamed it the “Cry-ocube”
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Pride in Microbiology @prideinmicro.bsky.social · 01/06/2026
💪🏳️‍🌈 Little Microbes, Big Pride!🏳️‍🌈 💪 We wish everyone a wonderful Pride Month!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 03/06/2026
Your cells may be thriving but your abstract still needs submitting 🧬😬 Deadline: June 9 #CellBio2026 www.ascb.org/cellbio2026/
ascb.org
Cell Bio 2026 - An ASCB|EMBO Meeting
Attend Cell Bio 2026 - An ASCB|EMBO Meeting and network
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Archaea Power Hour @archaeapowerhour.bsky.social · 13/05/2026
Archaea Power Hour returns next WEDNESDAY, May 20th, at 10AM EST / 4PM CET for the final installment of our spring semester seminar series!! We have two exciting talks planned for you so check your email for the Zoom link (coming soon) or visit our website (link in bio) for more info on how to join.
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Archaea Power Hour @archaeapowerhour.bsky.social · 19/05/2026
Almost archaea time!! Tune in tomorrow, Wednesday, May 20th at 10 AM EST / 4PM CET for the last seminar of our spring series 🥲. We have an exciting methanogen double feature in store for you! First up, Dr. Christian will tell us about his work enriching a novel methanogen from the Great Salt Lake!
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Archaea Power Hour @archaeapowerhour.bsky.social · 19/05/2026
Second up tomorrow, we have Anupkumar Rai who will tell us about his work biochemically characterizing an oxygen detoxifying enzyme that helps everyone’s favorite methanogen, Methanosarcina acetivorans, grow in the presence of O2. Check your email or Slack for the Zoom link!!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 13/05/2026
Last one of the semester!! Be there or be H. walsbyi 🥁
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 12/05/2026
Reposting this as the deadline is less than a month from now! Spread the word!
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Buzz Baum @buzzbaum.bsky.social · 09/04/2026
🎉 This is also a symbolic moment for the field: around 50 years since Carl Woese and colleagues first recognised Archaea as a distinct domain of life, fundamentally changing our understanding of evolution.
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Cell Biology J-Club @cellclub.bsky.social · 21/04/2026
Bridging the lipid divide: archaeal ESCRT-III binds phosphoinositol and polarises the cytokinetic membrane www.biorxiv.org/content/10.6...
biorxiv.org
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Archaea Power Hour @archaeapowerhour.bsky.social · 21/04/2026
Second up tomorrow, April 22nd at 10AM EST / 4PM CET, Katy Weber will tell us about her interesting work to mechanistically characterize electron transfer in a reductase protein from Haloferax volcanii!! Visit the link in our bio for more info on how to join our community!!
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Archaea Power Hour @archaeapowerhour.bsky.social · 21/04/2026
Set your archaea alarms because APH starts tomorrow, Wednesday 4/22, at 10AM EST / 4 PM CET. We’ll start off with an intriguing talk from Dr. Alex Phillips about how droughts 🌵and floods 🌊 in the Great Salt Lake affect haloarchaeal inhabitants!! Check your email for the Zoom link!!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 20/04/2026
🚨Hear, hear, fellow microbial cell biologists!🚨 🦠 Bacterial and Archaeal Cell Biology will be represented again at this year’s CELL BIO (ASCB-EMBO) meeting! The deadline to be considered for a talk in our Minisymposium is June 9. Help us spread the word! www.ascb.org/cellbio2026/
ascb.org
Cell Bio 2023-An ASCB|EMBO Meeting
Network, learn, and collaborate with top cell biologists from around the globe.
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 17/04/2026
🚨 🦠 Don’t miss us next Wednesday!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 26/03/2026
Today was also the lab’s first sampling trip, hunting for archaea around Davis!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 25/03/2026
Join me in welcoming the lab’s first graduate student, Jaylen Bush! That’s a well-deserved slice, Jaylen 🍕
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 13/03/2026
Science Policy APH social edition next week!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 09/02/2026
Out now!
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Archaea Power Hour @archaeapowerhour.bsky.social · 15/12/2025
Second up this Wednesday, Jiayuan Cui will tell us about her exciting and rigorous research biochemically characterizing a radical SAM enzyme involved in archaeal monolayer lipid (GDGT) cross-linking. Check your email for the Zoom link or visit our website (link in bio) for more info on how to join!
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Archaea Power Hour @archaeapowerhour.bsky.social · 15/12/2025
Archaea Power Hour is back for our final session of the semester this WEDNESDAY, Dec. 17th, at 10AM EST / 4PM CET. We’ll start off with an intriguing talk from @fmacleod.bsky.social about his work uncovering unique intracellular membrane-bound compartments in an Asgard archaeon!!!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 15/12/2025
“Happy Holidarchaeays” to you too
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LGBTQ+ Cell Biologists @celllgbtq.bsky.social · 09/12/2025
Lastly, for those at #CellBio25, we will be having a social TONIGHT at Little Gay Pub (102 S 13th Street) at 8 p.m.! Come meet the LGBTQ+ committee and let's celebrate another great conference! #outinstem #LGBTQIA #LGBTQ #queerinstem #cellbio #cellbiology #ascb #CellBio2025
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 26/11/2025
Tomorrow!! Special Pohlschröder lab double feature, because we halove their work (going to pun hell now)
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Archaea Power Hour @archaeapowerhour.bsky.social · 25/11/2025
Archaeasalutations!! Archaea Power Hour is back tomorrow (Wednesday) at 10 AM EST / 4 PM CET!! Check your email for the Zoom link or sign up to join our mailing list here: docs.google.com/forms/d/e/1FAI…. Check out the two exciting talks we have planned for you:
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 07/11/2025
Stunning! Congrats @buzzbaum.bsky.social et al!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 07/11/2025
Rest in power Zara, you’ll be missed
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Fabai Wu @fabaiwu.bsky.social · 21/10/2025
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
nature.com
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 17/10/2025
Don’t miss the first APH meeting of the season this coming Wednesday!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 15/09/2025
Welcome to our first postdoc in the ACO Lab, Andy Garcia! 🎉
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 01/09/2025
Supporting each other as #newPI is very important, and @antonioserapio.bsky.social is great at it
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 30/08/2025
🚨 🚨 🗓️ The deadline to submit your abstract for the #ASCB2025 meeting in Philadelphia is this Wednesday, September 3!! Dyche Mullins and I are hosting the session “Cell Biology at the Extremes”. Thermophiles, psychrophiles, tardigrades, giant bacteria… now is your time to shine!! 🚨
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 25/06/2025
New hot fluorescent tag dropped!
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Svetlana Dodonova @dodonova-sveta.bsky.social · 26/05/2025
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 29/05/2025
The archaeal S-layer is not only pretty, it also carries crucial cellular functions, and the list keeps growing! @sshamphavi.bsky.social @marleenvw.bsky.social @archaellum.bsky.social and I wrote a little sheath sheet (+10 pts if you got the pun) 📖 Curr Opin Cell Biol 🔗 doi.org/10.1016/j.ce...
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 29/05/2025
What a year for the cell biology of archaeal chromosome segregation! 🧬 @joeparham19.bsky.social and @buzzbaum.bsky.social now add pieces to the SegAB puzzle by connecting it with cell division
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Joe Parham @joeparham19.bsky.social · 29/05/2025
To explore how ring assembly and DNA segregation might be coupled, we turned our attention to the ParA homologue, SegA, and its partner SegB, using antibodies kindly gifted by @acharlesorszag.bsky.social (see www.biorxiv.org/content/10.1...)
biorxiv.org
Archaeal SegAB forms a bipolar structure that promotes chromosome segregation in spherical cells
Archaeal segAB operons are thought to promote chromosome segregation, but their mechanism remains unknown. We employ comparative genomics, structural biology, genetic knockouts, and quantitative cell ...
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Archaea Power Hour @archaeapowerhour.bsky.social · 12/05/2025
In just 2 days on WEDNESDAY, May 14th at 10 AM EST / 4 PM CET, @fabaiwu.bsky.social will kick off our last spring APH session by telling us about his new research investigating the evolution of DNA replication machineries from Archaea to Eukaryotes!!! Visit our website (link in bio) for more info!
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Archaea Power Hour @archaeapowerhour.bsky.social · 12/05/2025
Think you're under pressure? Marion Illartin will close out our last APH session of the semester by telling us about her multidisciplinary approach to characterize how pressure regulates the SurR transcription factor in everyone's favorite barophile, Thermococcus barophilus!! Zoom in on May 14th!
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 08/05/2025
Don’t miss it!! Last APH of the season 🫶🏼
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PLOS Biology @plosbiology.org · 22/04/2025
The unique #CellEnvelope of #corynebacteria: @tbharat-lab.bsky.social &co map the C. glutamicum cell surface, revealing a patchy S-layer & specific assembly of the PS2 protein, thereby informing our understanding of cell envelopes that contain #MycolicAcids @plosbiology.org 🧪 plos.io/3Y6JNgw
Left: The atomic model of the PS2 lattice is shown in top and side views. PS2 hexamers are repeated in the 2D sheet with a lattice constant of 176 Å. Each PS2 monomer is colored and labeled separately within the hexamer, which repeats throughout the lattice (with pore dimensions highlighted). The side view of the lattice shows the smooth surface facing the extracellular space and rough surface with coiled-coil segments protruding towards the MM. Top right: Interactions at the hexameric and trimeric interfaces are stabilized by both hydrophilic and hydrophobic residues. Bottom right: A cell envelope tomogram was used to overlay the cryo-EM structure of the S-layer onto the in situ S-layer tomographic density. A single slice of the tomogram is shown, with the overlayed PS2 S-layer lattice in green and the tomogram in grayscale. The S-layer (surface layer), MM (mycomembrane), IM (inner membrane), and Cytosol are labeled.
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Buzz Baum @buzzbaum.bsky.social · 18/04/2025
Excited to announce the Molecular Biology of Archaea (MBoA) 2026! Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 17/04/2025
Coolest office poster, the Beaud - Gribaldo ToL 😎 Thank you @sgribaldo.bsky.social and @babebe.bsky.social 🫶🏼
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 16/04/2025
Preprint alert! I’m publishing my last paper from my postdoc work on archaeal cell biology, with @mullinslab.bsky.social, @archaellum.bsky.social, @samjlord.bsky.social, @marleenvw.bsky.social, @arghya93.bsky.social, and more great folks (thread below with more details)
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 10/04/2025
Never too late to repost a great paper ✨ Huge congrats to @archaeon-alex.bsky.social and the amazing Theopi Rados (and all the authors ofc) 🫶🏼
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 08/04/2025
🚨 Tune in this Wednesday for more exciting archaea science!
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American Society for Cell Biology @ascbiology.bsky.social · 11/03/2025
Nearly 40% of transgender and gender-nonconforming biologists report experiencing hostile behavior at work, according to the largest survey of LGBTQ+ biologists, created by ASCB's LGBTQ+ Committee. www.nature.com/articles/d41...
nature.com
Trans researchers under attack: LGBTQ+ biologists face hostile work environment
Largest survey of LGBTQ+ biologists finds 40% of trans and gender-nonconforming, and 20% of lesbian, gay, bisexual and queer researchers, experience hostility, intimidation or offensive behaviour at w...
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Archaea Power Hour @archaeapowerhour.bsky.social · 11/03/2025
Second up on Wednesday, March 12th, we'll have Priyanka Chatterjee talk to us about her intriguing research into quorum sensing in the salty Haloferax volcanii, identifying many key players in this cellular communication response in archaea! Check your email for the Zoom link!
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Archaea Power Hour @archaeapowerhour.bsky.social · 11/03/2025
Archaea Alert! We're just one day away from our next APH session! First up, @cjhines.bsky.social will tell us about his exciting work to uncover the elusive last step of coenzyme M biosynthesis and to demonstrate its effectiveness as an antioxidant!! Make sure to tune in on March 12th, 11AM EST!!
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