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fillouxlab.bsky.social

@fillouxlab.bsky.social
740 followers 984 following 87 posts
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Andrew Urquhart @starships-andrew.bsky.social · 24/09/2026
Another step in the #Starship story - they move via a circular intermediate. Helps explain how these elements horizontally transfer and means that we can modify them into transformation vectors (starmids). www.biorxiv.org/content/10.6...
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MPI for Biology Tübingen & Friedrich Miescher Laboratory @mpi-bio-fml.bsky.social · 21/09/2026
Meet the first of our creative postdocs: “I'm Daniela Ramirez, a postdoc studying plant-bacteria interactions and fascinated by microbes living within plants. My research uses bGWAS to uncover how Pseudomonas infects and colonizes Arabidopsis thaliana.” #PAWGermany #PAW2026 #PostdocAppreciationWeek
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Willem van Schaik @wvschaik.bsky.social · 20/09/2026
Brilliant paper by the labs of @epcrocha.bsky.social @jrpenades.bsky.social 'Mobile genetic elements drive a plasmid fusion and deletion lifecycle shaping evolution and antimicrobial resistance' www.nature.com/articles/s41...
nature.com
Mobile genetic elements drive a plasmid fusion and deletion lifecycle shaping evolution and antimicrobial resistance - Nature Communications
Plasmids drive bacterial adaptation, but how their diversity arises has remained unclear. Here, they show that in Staphylococcus aureus, mobile genetic elements repeatedly fuse and delete plasmids, re...
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Simona Huwiler @simonahuwiler.bsky.social · 18/09/2026
#AMR superbugs are getting tougher, but predatory bacteria like B. bacteriovorus can hunt them down! We show that model bacterium E.coli 🦠 can escape these ‘living antibiotic’ by evolution, mainly through OmpF porin loss. This comes at a cost. Details at: tiny.cc/2qpa101 #MicroSky, #Evolution
Evolutionary escape from predation.
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Alexander Harms @aharms485.bsky.social · 17/09/2026
Great talk by Akos Kovacs @evolvedbiofilm.bsky.social about circadian rhythm in Bacillus - crazy biology and ingenious approaches to study it! 🕰🦠🛠
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Ákos T Kovács @evolvedbiofilm.bsky.social · 17/09/2026
#InternationalMicroorganismDay is a great time to share a work just published in ISME Journal; a massive collaborative network at Forschungszentrum Jülich and Heinrich Heine University Düsseldorf by @frunzkelab.bsky.social and colleagues #Community & #siderophores academic.oup.com/ismej/advanc...
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fillouxlab.bsky.social @fillouxlab.bsky.social · 15/09/2026
Very tough race in Malaysia by #UTMB. 25.9K and 1012mD+. Anxious before but happy after 6h18'58".
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Philip Fowler @philipwfowler.bsky.social · 14/09/2026
Giulia Manina gets the @events.embl.org workshop on “The complexity of mycobacterial infections” underway at the @pasteur.fr. Looking forward to five days of talks and talking.
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T3SS @t3sss.bsky.social · 14/09/2026
Exploiting the bacterial type III secretion system of Pseudomonas aeruginosa to impact genomic recombination in murine lungs www.sciencedirect.com/science/arti...
sciencedirect.com
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Ákos T Kovács @evolvedbiofilm.bsky.social · 14/09/2026
Amazing talk at #EMBOBacNet by @audeber.bsky.social - anti-phage defense system motivating the discoveries of immun systems on the tree of life
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 14/09/2026
New in JB: O'Brien, Lima et al. identify a protein-modifying GNAT-family lysine acetyltransferase that impact biofilm formation by the oral microbe Streptococcus gordonii. pubmed.ncbi.nlm.nih.gov/42506740/ @asm.org #JBacteriol @microsky.bsky.social
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Arnaud Krebs @arnaudkr.bsky.social · 14/09/2026
your starter pack for Single Molecule Genomics! Why you should do it (or not) - How you should do it. Collective effort with @vram142.bsky.social @stirlingchurchman.bsky.social @naltemose.bsky.social A Stergachis M Stadler W Greenleaf @embl.org rdcu.be/PmzSEV529GRa
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Michael Sauer @michlwien.bsky.social · 08/09/2026
🦠 Feeling trusted: The FEMS Council in Stockholm elected me to be the 18th president of the Federation of European Microbiological Societies 🧫 This is quite an incredible position that makes me happy and proud and really looking forward to the tasks ahead.
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Julian Parkhill @julianparkhill.bsky.social · 08/09/2026
Chair in Bacteriology in Cambridge Department of Medicine. A great opportunity. Please circulate. www.cam.ac.uk/jobs/researc...
cam.ac.uk
Research Professor in the field of Bacteriology
Strengthening Cambridge's leadership in bacteriology research Bacterial infection and antimicrobial resistance remain among the most pressing global health challenges of our time. At Cambridge, the De...
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Brian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · 08/09/2026
Spirochetes do it differently! Evolutionary characterization and structure-guided discovery of the β-barrel assembly machinery in Treponema pallidum subsp. pallidum reveals a putative BamD-like protein www.sciencedirect.com/science/arti... #MicroSky
Figure 1. Workflow for the identification of components in the T. pallidum BAM system. This schematic illustrates the overall strategy used to identify and validate candidate components of the BAM system in T. pallidum. First, phylogenetic analysis of Omp85 family proteins and comparative analysis of bamA gene neighborhoods were performed to investigate the evolutionary features and genomic organization of BAM-associated components in Treponema and Borrelia. Subsequently, candidate BAM proteins were identified through two complementary approaches: (i) a structure-guided computational strategy based on structural similarity searches; and (ii) an experimental proteomic strategy using IP-MS analysis. Candidate proteins identified from both approaches were further evaluated by in vitro protein-protein interaction assays. Proteins exhibiting specific interaction with Tp0326 were subsequently subjected to domain identification, structural modeling and interface analysis.
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EMBL Events @events.embl.org · 07/09/2026
At the start of 2026, EMBL lost long-serving colleague and Interim Director General Peer Bork. Join us in commemorating Peer and his legacy at the #EMBLBorkMemorial. Submit your abstract by 10 November: s.embl.org/pbs27-01-bl
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Olivier Borkowski @oborkowski.bsky.social · 05/09/2026
Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up doi.org/10.1038/s414...
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fillouxlab.bsky.social @fillouxlab.bsky.social · 05/09/2026
I really enjoyed delivering this lecture in the SBS seminar series at NTU. @scelse.bsky.social
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Microbes.Info @microbesinfo.bsky.social · 04/09/2026
🦠🫁 A #bacterial #protein fragment called #corisin can drive #PulmonaryFibrosis by damaging #lung cells, while an experimental #antibody reduced #fibrosis and improved survival in mice. #Microbes #Bacteria #Microbiome #Biomed #Microsky via @sciencex.bsky.social medicalxpress.com/news/2026-09...
medicalxpress.com
Bacterial protein fragment drives tissue fibrosis, but antibody treatment can help
A bacterial protein fragment called corisin drives pulmonary fibrosis by infiltrating and disrupting cells' quality-control systems, researchers at the University of Illinois Urbana-Champaign and Mie…
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Jan-Willem Veening @veeninglab.com · 03/09/2026
Clonal does not mean uniform. #MicroSky Our new review explores how genetically identical bacteria adopt different cell states, and how that diversity shapes survival, cooperation, antibiotic responses and gene transfer. 🧵 doi.org/10.1146/annu...
doi.org
Decoding Bistability and Drivers of Phenotypic Variation in Bacteria
In a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise i...
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Murphy Lab @bjmurphylab.bsky.social · 03/09/2026
Check out our newest preprint! tinyurl.com/mttvaed3 Max was able to resolve cryo-EM structures of the DsrMKJOP complex, which catalyzes a critical step in sulfur metabolism and sulfide production is sulfate-reducing microbes. The main findings are summarized in the video below 📽️
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EMBL @embl.org · 03/09/2026
Congratulations to @florianwollweber.bsky.social, the recently appointed Group Leader at EMBL Grenoble, who received an ERC Starting Grant worth approximately €2 million to investigate the origins of eukaryotic cell complexity. bit.ly/4gNwEBk
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European Research Council (ERC) @erc.europa.eu · 03/09/2026
📣 Good news! 📣 Results of the ERC 2026 Starting Grant call are out! Funding worth a total of €705 million will go to 421 early-career researchers across Europe. Discover who, what and where 👉 link.europa.eu/9M3MmN 🧪 #ERCStG #FrontierResearch #HorizonEurope 🇪🇺 @scienceinnovation.ec.europa.eu
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Ákos T Kovács @evolvedbiofilm.bsky.social · 03/09/2026
Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 PNAS from Dan Kearns lab www.pnas.org/doi/10.1073/... #MicroSky
pnas.org
Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 | PNAS
Flagella are large transenvelope nanomachines but how they transit the peptidoglycan in gram-positive bacteria is poorly understood. A recent model...
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Evgenii Protasov @evgenii-protasov.bsky.social · 03/09/2026
Putative gatekeepers of incoming DNA: 3′ exonucleases in natural transformation and bacterial evolution #microbiology #DNA #exonucleases #MicroSky www.sciencedirect.com/science/arti...
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PLOS Biology @plosbiology.org · 30/08/2026
Why do some #bacteria #evolve #antibiotic resistance more readily than others? This study shows that naturally occurring single nucleotide polymorphisms in the PhoQP system change how readily E. coli evolves trimethoprim resistance and which mutations enable it. 🧪 #AcademicSky plos.io/4qCDXQM
Proposed model for the contribution of polymorphisms towards evolvability of resistance, and the role of fitness cost of TMP resistance in determining the optimal level of PhoQ activity during evolution.
A: Polymorphisms influence evolvability under drug pressure if they have epistatic interactions with adaptive mutations. Positive epistasis between pre-existing polymorphisms and adaptive mutations promotes the evolution of resistance, i.e., enhances evolvability of resistance. In contrast, negative epistasis diminishes evolvability. In addition, polymorphisms with negative epistasis can also drive adaptation to antibiotics through novel mutational paths. B: PhoQP signalling pathway across different mutants from the present study. The impact of PhoQ activity on trimethoprim resistance due to DHFR expression is correlated with fitness cost due to RpoS cross-activation. Genetic variation in the pathway is brought about by naturally occurring polymorphisms or drug-selected adaptive mutations. These genetic changes in the pathway activate signalling to different extents at the molecular level, thereby altering global transcriptome to different extents. Scaling of trimethoprim resistance level and fitness cost leads to changes in the concentration of antibiotic required to select for different levels of PhoQ/PhoP pathway activity. The presence of a hypersensitising allele of DHFR drove E. coli towards a high activity, high cost PhoQ mutant demonstrating how polymorphisms can change the mutational landscape of adaptation to antibiotics
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 01/09/2026
Molecule of the Month: Biofilms Bacterial communities glued together and protected by biological polymers More at PDB-101:
pdb101.rcsb.org
PDB101: Molecule of the Month: Biofilms
Bacterial communities glued together and protected by biological polymers
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Beckmann Lab @beckmannlab.bsky.social · 01/09/2026
Preprint alert: a helicase watching the ribosomal A-site 👀🧬 Our cryo-EM structure reveals how yeast Dhx29 senses mRNA hairpins forming in the A-site and positions its helicase at the mRNA entry channel to resolve them during translation elongation: doi.org/10.64898/202... #cryoEM #ribosome #RNA
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Jan-Willem Veening @veeninglab.com · 28/08/2026
I hadn't thought about the problem of division site selection in a long time. Really cool to see these new studies shining fresh light on such a fundamental question. Especially checkout this work by @aducret.bsky.social & Christophe Grangeasse: doi.org/10.1038/s415...
doi.org
Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae - Nature Microbiology
Sequential peptidoglycan carboxylase activity of DacA and DacB generates a local peptidoglycan signature that recruits MapZ and establishes the division site at the Streptococcus pneumoniae cell equat...
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Omar El-Halfawy @omarel-halfawy.bsky.social · 30/08/2026
Happy to share our recent paper at @pubs.acs.org's #ACSInfectDis studying the antibiotic responses of MRSA, one of the most common pathogens in paediatric patients with Cystic Fibrosis (CF), in CF artificial sputum compared to standard lab test conditions. pubs.acs.org/aidcbc/artic...
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fillouxlab.bsky.social @fillouxlab.bsky.social · 28/08/2026
Very enjoyable Symposium on #AMR in Seoul. Also great opportunity to meet old friends and colleagues, Kevin Pethe, Gadi Frankel and Eduardo Rocha
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Microbes.Info @microbesinfo.bsky.social · 27/08/2026
🐄🧫 An #enzyme discovered in the #cow #gut can disrupt #bacterial #Biofilms, potentially offering a new strategy for tackling persistent #infections. #Microbes #Bacteria #AMR #AntimicrobialResistance #Microsky via @sciencex.bsky.social phys.org/news/2026-08...
phys.org
Cow gut enzyme could help target bacterial biofilms and antibiotic-resistant infections
The bacterium Acinetobacter baumannii poses a substantial threat in health care settings, readily forming biofilms on wounds and medical surfaces and contributing to persistent infections and delayed…
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The Royal Society @royalsociety.org · 27/08/2026
Professor Bonnie Bassler is awarded the Copley Medal for her discovery of the universality of chemical communication in bacteria and for her idea that interfering with this communication could form the basis of novel anti-bacterials. #RSMedals royalsociety.org/medals-and-prizes/…
A woman with dark hair and a light blue shirt smiles at the camera in front of a bright white background.
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Prof Jenny Rohn @jennyrohn.bsky.social · 24/08/2026
“Among 9642 infection episodes analysed, approximately 75% were associated with AMR bacteria with crude 28-day mortality upwards 40% among patients with multidrug-resistant infections.” Getting closer to estimating the true burden of #AMR #IDSky
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Ákos T Kovács @evolvedbiofilm.bsky.social · 23/08/2026
Decoding Bistability and Drivers of Phenotypic Variation in Bacteria Annual Reviews in Microbiology by Jesús Cámara-Almirón, Milena Jaskólska, and @veeninglab.com at @dmf-unil.bsky.social www.annualreviews.org/content/jour...
annualreviews.org
Decoding Bistability and Drivers of Phenotypic Variation in Bacteria
In a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise i...
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Microbes.Info @microbesinfo.bsky.social · 22/08/2026
⚡🦠 Scientists discovered internal “power cables” that help #Bacteria move #electrons during #respiration, revealing a remarkable mechanism for #microbial #energy production. #Microbiology #Bioenergetics #CellBiology #Microsky via @sciencex.bsky.social phys.org/news/2026-08...
phys.org
Some bacteria build internal 'power cables' to extend respiration beyond the cell membrane
All living cells need energy, and most generate it through respiration, a series of chemical reactions normally confined to the cell membrane. Because this machinery takes up space, a cell's…
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Ákos T Kovács @evolvedbiofilm.bsky.social · 20/08/2026
Bacterial small regulatory RNAs @natrevmicro.nature.com Review by Kai Papenfort (FSU Jena, Germany / @microverse.bsky.social) www.nature.com/articles/s41...
nature.com
Bacterial small regulatory RNAs - Nature Reviews Microbiology
In this Review, Papenfort discusses established and emerging aspects of bacterial small RNAs (sRNAs), their molecular mechanisms and regulatory principles, and the global impact of sRNAs on cellular g...
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Microbiology Society @microbiologysociety.org · 20/08/2026
Missed our Annual Conference this year? Want to re-watch the incredible Prize Winner Lectures and Hot Topic? Follow this link to catch up on all the sessions: bit.ly/4g7UgS7
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EMBL @embl.org · 20/08/2026
A single phage enzyme can target thousands of bacterial proteins, shutting down host defences, a new EMBL study shows. The study provides novel insights into bacteria-virus interactions and opens up new possibilities for bioengineering for phage therapy. www.embl.org/news/science...
Illustration depicting how T7 kinase, a phage enzyme, modifies many proteins inside an infected bacterium, helping shut down its defence mechanisms. Credit: Daniela Velasco/EMBL
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Australian Research Council @arc-gov-au.bsky.social · 19/08/2026
This #NationalScienceWeek, discover ARC-funded research exploring how microbes found in the wax moth caterpillar could help break down plastic waste. Professor Amy Cain's work is advancing new biological approaches to recycling and environmental sustainability: www.arc.gov.au/news-and-pub...
Professor Amy Cain works with laboratory equipment, seated beside a benchtop bioreactor system connected by numerous tubes and sensors. Wearing a white laboratory coat, Professor Cain adjusts part of the apparatus while surrounded by glass vessels and scientific instrumentation in a modern research laboratory.
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BejaLabTechnion @bejalab.bsky.social · 19/08/2026
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences www.nature.com/articles/s41...
nature.com
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
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Rhys Grinter @rhyswg.bsky.social · 18/08/2026
Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself. doi.org/10.1038/s415... 1/5
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Microbes.Info @microbesinfo.bsky.social · 19/08/2026
🧫🧬 Billions of years of #evolution have equipped #Bacteria with sophisticated #biological machinery that scientists are now studying for new technological applications. #Microbiology #Biotech #SyntheticBiology #Microsky via @sciencex.bsky.social phys.org/news/2026-08...
phys.org
Nature has spent billions of years fighting bacteria. AI could help us learn its secrets
Tiny viruses that infect bacteria could one day help us tackle infections that antibiotics can no longer treat. But first, scientists need to understand how these viruses work, and artificial…
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STCmicrobeblog @stcmicrobeblog.bsky.social · 19/08/2026
here's about the bacterial version of 𝘐𝘮𝘱𝘢𝘵𝘪𝘦𝘯𝘴 𝘯𝘰𝘭𝘪-𝘵𝘢𝘯𝘨𝘦𝘳𝘦 ("touch me not") #MicroSky
Name
    Impatiens noli-tangere

Family
    Balsaminaceae

Original book source: Prof. Dr. Otto Wilhelm Thomé Flora von Deutschland, Österreich und der Schweiz 1885, Gera, Germany

Permission granted to use under GFDL by Kurt Stueber
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Félix Ramos-León @felixrl.bsky.social · 18/08/2026
Excited to share my latest work in the @ramamurthilab.bsky.social, now in @cp-cellreports.bsky.social! We show that division geometry organizes surface adhesins in S. aureus and enables the formation of abscess communities that protect bacteria from immune cells. www.cell.com/cell-reports...
cell.com
Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation
Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...
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Nature Microbiology @natmicrobiol.nature.com · 17/08/2026
Out Now! Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota #MicroSky
go.nature.com
Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota
Nature Microbiology, Published online: 17 August 2026; doi:10.1038/s41564-026-02450-zBacillus subtilis Ncp and NADH dehydrogenase form tube-like filaments with phospholipid-lined chambers that associate with quinones, which can expand bioenergetic capacity and support respiratory electron transfer.
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ASM @asm.org · 17/08/2026
Microbes are critical for building a more sustainable world. The American Academy of Microbiology is advancing the scientific understanding about microbiology & sustainability to promote microbe-based innovations. Learn how you can join these efforts: asm.social/335
"Microbes for Sustainability" over a collage of corn crops and a water treatment plant.
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fillouxlab.bsky.social @fillouxlab.bsky.social · 17/08/2026
It was nice to talk at the #FAOBMB conference in Hong Kong and be hosted by Aixin Yan. Spectacular view from Victoria Peak.
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Elin Videvall @elinvidevall.bsky.social · 16/08/2026
#ISME20 in Auckland, New Zealand is officially starting! @isme-microbes.bsky.social
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