The mechanism of herpes simplex virus type 1 (HSV-1) genome replication remains not fully understood. Here, the authors find that the HSV-1 origin binding protein UL9 does not mediate DNA looping but ...

Single-molecule fluorescence microscopy combined with optical tweezers has enabled the direct observation of diffusing proteins on tethered DNA. These and complementary techniques reveal facilitated o...

Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...

Deformable Neural Radiance Fields creates free-viewpoint portraits (nerfies) from casually captured videos.

Researchers at the University of Birmingham have been successful in the most recent round of the Wellcome Career Development Awards.

The 2026 Gordon Research Seminar on Single Molecule Approaches to Biology (GRS) will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

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Cas9 structures explain topology sensing and off-target activation.

Cas9 structures explain topology sensing and off-target activation.

YouTube video by MRC Laboratory of Molecular Biology

Researchers at Imperial College London, the MRC Laboratory of Medical Sciences (LMS), and the University of Sheffield have shown that the physical tw...

Cas9 structures explain topology sensing and off-target activation.

CRISPR is a powerful DNA-editing tool that has underpinned huge advancements in human healthcare in the last decade. It is a precision tool, but is not perfect, and misplaced DNA edits can compromise ...