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Géraldine Laloux

@lalouxlab.bsky.social
949 followers 343 following 45 posts

Bacterial cell biology lab in the Kingdom of Belgium - Exploring predatory bacteria in space and time - F.R.S.-FNRS research associate / UCLouvain Associate Prof / WEL-RI investigator

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Reposted by Géraldine Laloux
Coralie Tesseur @coralietesseur.bsky.social · 09/07/2026
So excited to share our new preprint! 🎉🤩 Check it out to discover how we investigated the role and spatiotemporal dynamics of an essential Tad nanomachine during the lifecycle of our favorite bacterial predator, B.bacteriovorus 🦠 Many thanks to everyone who made this work possible!
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Géraldine Laloux @lalouxlab.bsky.social · 09/07/2026
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
biorxiv.org
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
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Géraldine Laloux @lalouxlab.bsky.social · 15/05/2026
Today is the last day to submit your abstract for the EMBO Bacterial Networks (BacNet) meeting #EMBOBacNet! 🧫 Selected participants will be informed by June 30th. meetings.embo.org/event/26-bac...
meetings.embo.org
Bacterial networks
Building on recent breakthroughs in structural, imaging, and systems-wide approaches, this EMBO Workshop will showcase novel insights into the spatiotemporal organization and interconnectivity of com…
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Melanie Blokesch @mblokesch.bsky.social · 29/03/2026
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
tiny.cc
Open Positions
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Géraldine Laloux @lalouxlab.bsky.social · 20/11/2025
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet 🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info: meetings.embo.org/event/26-bac... 👩‍🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social #MicroSky
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Fusion Conferences @fusionconf.bsky.social · 16/03/2026
ANNOUNCEMENT! Programme now LIVE on our website for the #ProkaryoticCellBio conference! Check it out here, a reminder that the registration deadline is 13 April!➡️https://bit.ly/4rEH9KP
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Géraldine Laloux @lalouxlab.bsky.social · 05/03/2026
#MicroSky Please RT @erc.europa.eu-funded postdoc position in my lab to identify the molecular basis of prey-predator interactions using our favorite micro-vampire Bdellovibrio exovorus as a model. Let's find what the bite is made of! 🧛 Flexible start date. Info: euraxess.ec.europa.eu/jobs/415877
euraxess.ec.europa.eu
Postdoctoral researcher in molecular and cellular bacteriology - ERC CoG VAMPIRE
The research group of Prof Géraldine Laloux at the de Duve Institute (UCLouvain) is looking for a highly motivated postdoc to elucidate the molecular factors underlying bacterial prey-predator interac...
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Géraldine Laloux @lalouxlab.bsky.social · 26/02/2026
Fantastic thread and data by @brunlabcaulo.bsky.social on how a single ATPase powers opposite pilus extension/retraction activities.
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Anthony Vecchiarelli @cellforganized.bsky.social · 12/12/2025
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University! GRS will be on June 5-6, 2027 GRC will be from June 6-11, 2027 Block off your calendars Prokaryotic Cell Biologists! More details to come! Please repost!
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Nathan Fraikin @nfrk92.bsky.social · 10/12/2025
academic.oup.com/nar/article/... Collaboration with Y. Yamaichi. Killing donor bacteria in conjugation mixes using water enables transcriptomic profiling of early plasmid genes ! Superb tool for studying zygotic induction of these early genes, which include anti-SOS and anti-RM factors. #microsky
academic.oup.com
Selective elimination of donor bacteria enables global profiling of plasmid gene expression at early stages of conjugation
Abstract. Conjugative plasmids are a major driving force for the dissemination of antimicrobial resistance. During conjugation, plasmid DNA is transferred
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Clare T 🏳️‍🌈 @claret-micro.bsky.social · 09/12/2025
Your societies need you #MicroSky! Editorial from the European Academy of Microbiology Task Force: Society journals matter—supporting science through renewed commitment: academic.oup.com/microlife/ar...
academic.oup.com
Editorial: society journals matter—supporting science through renewed commitment
Scientific publishing is in flux. Commercial publishers have expanded their influence, driven by profit margins and citation metrics. At the same time, a g
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Jovana Kaljević ⬜️ @jovanakaljevic.bsky.social · 04/12/2025
Our preprint is now published in PNAS! This came together thanks to a great collaboration with Antoine Hocher and a strong team effort from the Le Lab. Thank you to the reviewers and to everyone who helped improve it. I hope ParB aficionados will enjoy it. www.pnas.org/doi/10.1073/...
pnas.org
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states thro...
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Géraldine Laloux @lalouxlab.bsky.social · 20/11/2025
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet 🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info: meetings.embo.org/event/26-bac... 👩‍🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social #MicroSky
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Michael Deghelt @michaeldeghelt.bsky.social · 13/11/2025
The diderm cell envelope is not a stack of layers but a unified scaffold of Inner Membrane–Peptidoglycan–Outer Membrane. We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria. Curr Opin Microbiol: doi.org/10.1016/j.mi... #microsky 🔬
doi.org
Redirecting
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Yves Brun lab @brunlabcaulo.bsky.social · 06/11/2025
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
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Martin Thanbichler @thanbichlerlab.bsky.social · 02/11/2025
📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc
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Géraldine Laloux @lalouxlab.bsky.social · 17/10/2025
#MicroSky
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 10/10/2025
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation www.biorxiv.org/content/10.1101/202…
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Renske van Raaphorst 🟥 @vrrenske.bsky.social · 26/09/2025
Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n
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Géraldine Laloux @lalouxlab.bsky.social · 25/09/2025
📝New preprint! #MicroSky 🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy. 🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation. www.biorxiv.org/content/10.1...
biorxiv.org
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
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Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025
🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4
academic.oup.com
Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference
Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.
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Géraldine Laloux @lalouxlab.bsky.social · 21/08/2025
Another great contribution to the “Cell Regulation” themed issue of Current Opinion in Microbiology www.sciencedirect.com/special-issu...
sciencedirect.com
Current Opinion in Microbiology | Cell regulation (2025) | ScienceDirect.com by Elsevier
Read the latest articles of Current Opinion in Microbiology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
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Géraldine Laloux @lalouxlab.bsky.social · 29/07/2025
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky www.nature.com/articles/s41...
nature.com
Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology
Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.
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Daniela Barillà @danielabarilla.bsky.social · 26/07/2025
Chromosome enthusiasts, York is calling! Join us at The Biology & Physics of Chromosomes www.eventsforce.net/biochemsoc/f... Late breaking abstract deadline 📆 7 August @biophychrom.bsky.social @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social #microsky
Wild flower meadow in the foreground with York Minster in the background.River Ouse in York and along the bank the Hospitium hall where the conference dinner will take place. The Hospitium was part of St Mary’s Abbey that was built during Medieval times.
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Géraldine Laloux @lalouxlab.bsky.social · 25/07/2025
#MicroSky Summer read! Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator & prey 🧛 How do they do it? Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Strategies and mechanisms of contact-dependent predation in bacteria
Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…
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Géraldine Laloux @lalouxlab.bsky.social · 16/07/2025
We wrote 2 📕 chapters with tips & tricks to identify protein-protein interactions in bacteria 🦠 1) In vivo proximity labeling with miniTurbo link.springer.com/protocol/10.... 2) An adapted polar recruitment assay feat. E. coli as a test tube link.springer.com/protocol/10..... Enjoy #MicroSky 🧪
media.tenor.com
a man wearing sunglasses and a white t-shirt is holding something in his hands .
ALT: a man wearing sunglasses and a white t-shirt is holding something in his hands .
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Yves Brun lab @brunlabcaulo.bsky.social · 09/07/2025
Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...
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Géraldine Laloux @lalouxlab.bsky.social · 07/07/2025
#MicroSky
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Tung Le @tunglejic.bsky.social · 09/05/2025
1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below. shorturl.at/o6S1w
shorturl.at
A bacterial CARD-NLR immune system controls the release of gene transfer agents
Bacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are ...
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Martin Thanbichler @thanbichlerlab.bsky.social · 02/04/2025
#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH" Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages) Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
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mosorio91.bsky.social @mosorio91.bsky.social · 15/03/2025
I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved.
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Yves Brun lab @brunlabcaulo.bsky.social · 12/03/2025
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See lnkd.in/dVVk4N3s. #microsky
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Dame lab at Leiden University @damelab.bsky.social · 20/02/2025
In @molecularmicro.bsky.social: two special issues on Prokaryotic Chromosome Organization. Many excellent contributions, including a vision article: 'Future directions of the Prokaryotic Chromosome Field', outcome of BioPhyChrom 2023 @biophychrom.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Future Directions of the Prokaryotic Chromosome Field
In September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of ....
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Géraldine Laloux @lalouxlab.bsky.social · 04/12/2024
A million thanks to the ERC for the opportunity to explore bacterial predatory attacks and cell cycle switches with our VAMPIRE Consolidator grant @deDuveInstitute @UCLouvain_be @frsFNRS 🦠 🔬 🧛
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Yves Brun lab @brunlabcaulo.bsky.social · 13/11/2024
2 days left. Asst/Assoc Prof position in bacteriology, Université de Montréal. Deadline ***Nov. 15*** come join our growing community of bacteriologists. BTW Canada is the USA’s Bluesky!
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Eduardo Rocha @epcrocha.bsky.social · 04/04/2024
New job offer: we search a postdoc (bioinformatics) to work on mobile genetic elements and gene flow in bacteria, with a focus on antibiotic resistance within a consortium including bioinformatics, synthetic biology, epidemiology & biochemistry. See research.pasteur.fr/en/job/postd... #MicroSky
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Géraldine Laloux @lalouxlab.bsky.social · 14/03/2024
Former PhD student Ophélie Remy and I are cell poles enthusiasts, so we were delighted to offer a brief perspective on bacterial polarity for the Special Issue on Cell and tissue polarity in the Journal of Cell Science. journals.biologists.com/jcs/article-.... #MicroSky
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Géraldine Laloux @lalouxlab.bsky.social · 13/03/2024
#MicroSky
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Géraldine Laloux @lalouxlab.bsky.social · 13/03/2024
Our last story on cell polarity in Bdellovibrio bacteriovorus is now published in Journal of Bacteriology! Feat. a protein that marks the "head" of future daughter cells before non-binary division, a new DivIVA pattern, and 1st use of proximity labeling in Bdello! journals.asm.org/doi/10.1128/...
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STCmicrobeblog @stcmicrobeblog.bsky.social · 02/02/2024
cell divisionist take note 👇 meetings.embo.org/event/24-z-r...
meetings.embo.org
Archaeal and bacterial cell division: Beyond the Z-ring
The objective of this EMBO Workshop is to discuss advances in prokaryotic cell division. Most archaea and bacteria divide using a ring-structure formed by the tubulin homologue FtsZ, the Z-ring. Rese�...
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Daniela Barillà @danielabarilla.bsky.social · 03/12/2023
MRC- funded PhD project at the interface between biology & physics to investigate the segregation of an antibiotic resistant plasmid. Interdisciplinary training with super supportive supervisors. In the beautiful historic city of York. Please re-post, thanks! #microsky 🦠🧫🧪 📆17 December
3 dimensional structure of a plasmid segregation protein bound to ATP.
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Géraldine Laloux @lalouxlab.bsky.social · 30/11/2023
New preprint! We delved into how bacterial cells establish their polarity, a task that is even more challenging when they produce >2 daughter cells by non-binary division: how to distinguish the head and the tail in all these progenies? www.biorxiv.org/content/10.1... #MicroSky
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Renske van Raaphorst 🟥 @vrrenske.bsky.social · 30/11/2023
🧫The lab is on a roll! 🦠How do you work out what's front & back when cells don't divide in two but in roughly 2-21? read Ophelie's quest to find clues --> www.biorxiv.org/content/10.1...
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Géraldine Laloux @lalouxlab.bsky.social · 23/11/2023
Vampire bacteria strike back in this new inspiring piece by @christophstc.bsky.social for @stcmicrobeblog.bsky.social #MicroSky
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Géraldine Laloux @lalouxlab.bsky.social · 20/11/2023
A vampire-themed perspective on our recent preprint 🧛, written by Christoph @christophstc.bsky.social for the fantastic microbiology blog "Small Things Considered" @stcmicrobeblog.bsky.social. Link to the blog post below👇 and to our preprint here 👉 www.biorxiv.org/content/10.1... #MicroSky
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Géraldine Laloux @lalouxlab.bsky.social · 15/11/2023
Fantastic work by @GoldlustKelly and the @tacc_c Lesterlin lab demonstrating distant conjugative transfer of ssDNA through the F pilus. 👏 #MicroSky www.pnas.org/doi/10.1073/...
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Géraldine Laloux @lalouxlab.bsky.social · 10/11/2023
A super useful method to identify the network of your favorite protein, working like a charm in bacteria 🦠 🧫 👏 Ophélie Remy & Yoann Santin #MicroSky link.springer.com/protocol/10....
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Simonetta Gribaldo @sgribaldo.bsky.social · 07/11/2023
"Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes" Congratulations @augustsilale.bsky.social for this beautiful work on Veillonella, together with C. Beloin, B. van den Berg (soon on bsky) and @sykhalid.bsky.social ! #MicroSky Free pdf 👇👇 rdcu.be/dqp33
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Géraldine Laloux @lalouxlab.bsky.social · 04/11/2023
Congratulations again to Milos Tisma (Dekker lab) and our former PhD student Jovana Kaljevic for their well deserved « emerging talent in molecular microbiology » award🥇 🧫 🦠! Read Jovana interview in Molecular Microbiology here: onlinelibrary.wiley.com/do/10.1111/m...
onlinelibrary.wiley.com
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Géraldine Laloux @lalouxlab.bsky.social · 26/10/2023
🦠 🧫 Halloween preprint 🎃 from our lab! Live-cell + cryoEM imaging of the lifecycle of B. exovorus, a predatory bacterium that feeds on Caulobacter (+ close relatives) while firmly attached to the prey surface. The S-layer does not protect against vampirization… and B.exovorus divides into triplets 😮
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