iiinova — where your digital self keeps evolving

Reposted by Chao Qi

Kai Yi @kaiyi94.bsky.social · 29/09/2026

1/7 Excited to share GuideFlip! We use guided discrete flow matching to co-design protein sequences and structures for flexible interactions, with experimental validation across three systems: α-synuclein, RBX1 and active-state GPCR nanobodies.

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 11/03/2026

Holy smoke. What ultimately happened???

Image from their link showing evidence of fabricated references

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Sjors Scheres @sjorsscheres.bsky.social · 09/03/2026

This expands our knowledge of tau filaments from frontotemporal dementia and parkinsonism linked to chromosome 17. Because these mutations drive the formation of the Pick fold, they may also be useful in the development of model systems for Pick's disease in cells or animals.

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Sjors Scheres @sjorsscheres.bsky.social · 09/03/2026

We report the Pick fold and 2 variants thereof for tau filaments from individuals with MAPT mutations encoding for D252V, G272V, S320F and Delta_G389-I39, and we use these to reconstitute the Pick fold with recombinant tau in vitro. By @qcxy8886.bsky.social. 🥳 www.biorxiv.org/content/10.6...

biorxiv.org

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Atanas G. Atanasov @atanas-g-atanasov.bsky.social · 22/02/2026

Measles doesn’t always end when the rash fades. For one woman, it returned 25 years later — as a fatal brain disease. SSPE affects 1 in 50,000 measles cases. There’s no cure. There is prevention. This story will stay with you. ⬇️ www.independent.co.uk/news/health/...

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Sjors Scheres @sjorsscheres.bsky.social · 20/02/2026

The amyloid packing difference (APD) is a new metric to compare amyloid structures. Analysis of disease-specific structures provides context for the interpretation of APDs for new comparisons. I hope it will be useful! 🤗 www.biorxiv.org/content/10.6...

biorxiv.org

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Allegretti Lab @matteoall.bsky.social · 19/12/2025

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

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Sjors Scheres @sjorsscheres.bsky.social · 09/12/2025

Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI

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Sjors Scheres @sjorsscheres.bsky.social · 29/10/2025

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

mrc.tal.net

Quick Check Needed

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Sjors Scheres @sjorsscheres.bsky.social · 05/10/2025

Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead! #OpenSoftwareAcceleratesScience www.biorxiv.org/content/10.1...

biorxiv.org

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Chao Qi @qcxy8886.bsky.social · 17/07/2025

The best cover🥰, paired cats & paired helical filaments.

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Sjors Scheres @sjorsscheres.bsky.social · 16/07/2025

Finally, the paper by @qcxy8886.bsky.social on #cryoEM of tau mutants V337M and R406W is out in NSMB (which is not the fastest journal). Tau filaments with these mutations have the same structures as in AD, which may be useful for the development of faster models. www.nature.com/articles/s41...

nature.com

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W - Nature Structural & Molecular Biology

Qi et al. used cryo-electron microscopy to determine the structures of tau filaments from the brains of individuals with MAPT mutants V337M and R406W, known to give rise to frontotemporal dementias. T...

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Sjors Scheres @sjorsscheres.bsky.social · 10/04/2025

At the #Synuclein2025 in Cambridge this week. There is a large unmet need for help with #cryoEM structure determination of amyloids.

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/04/2025

“If you’re really curious about science, then you should do it.” We recently caught up with David Barford, Group Leader in the LMB’s Structural Studies Division, to learn more about his career, what inspires him and his group’s research into kinetochore complexes. youtu.be/qaudt961iMU

youtu.be

From the scientist's view: a conversation with David Barford

YouTube video by MRC Laboratory of Molecular Biology

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Sjors Scheres @sjorsscheres.bsky.social · 01/04/2025

I found the below in the stand of @stressmarq.bsky.social at #ADPD2025. When I asked how these "tau oligomers" were made, I was told this was a company secret! 😱😱😱 How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?

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Sjors Scheres @sjorsscheres.bsky.social · 28/03/2025

Alzforum has written a piece on our most recent updates to the structure-based classification of tauopathies. 🥳 www.alzforum.org/news/researc...

alzforum.org

Filling in the Family Tree—AD, CTE Folds Spotted in Other Tauopathies | ALZFORUM

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