Circumventricular organs are specialized brain regions lacking a blood-brain barrier. Van Hove et al. reveal that these regions harbor unique microglia and border-associated macrophage populations that respond to ageing and metabolism and are partly derived from fetal monocytes entering during a perinatal window, which can fully adopt the microglia identity.

García-Gómez et al. identify a transient state, termed the proliferative pause, that enables the survival of micrometastases during vascular co-option by buffering organ-imposed stress. Targeting vulnerabilities associated with this state suppresses metastatic progression and relapse, revealing opportunities for preventive intervention.

The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophag...

Liu et al. develop Mitotrek, a method that uses single-cell multi-omics with mitochondrial DNA clonal tracing to map the clonal origins of innate immune cells in human tumors. They reveal that tumor myeloid populations arise from circulating monocytes with pre-existing epigenetic fate biases, suggesting that tumor immunity is shaped before tumor infiltration.

Molecular testing in hematology requires different assays for disease subgroup identification, risk stratification and selection of appropriate treatment regimens. Yet, molecular tests are not necessa...

Streptococcal meningoencephalitis disrupts homeostatic, skull bone marrow–derived monocyte and macrophage trajectories in the dura.

Yang et al. demonstrate that chronic stress accelerates glioma growth by inducing bone-marrow-derived C5aR1+ stress-associated macrophages (SAMs) in tumor-bearing mice. Stress-induced sympathetic nerve activation induces ADRB2+ monocytes to become CD36+ lipid-laden SAMs. SAMs depletion suppresses stress-related glioma tumor growth, and SAM abundance correlates with self-reported stress levels and portended prognosis in patients.

Liu et al. develop Mitotrek, a method that uses single-cell multi-omics with mitochondrial DNA clonal tracing to map the clonal origins of innate immune cells in human tumors. They reveal that tumor myeloid populations arise from circulating monocytes with pre-existing epigenetic fate biases, suggesting that tumor immunity is shaped before tumor infiltration.

A spatiotemporal atlas of the human meninges during early-to-mid gestation identifies asynchronous layer development and transcriptomic features of meningeal cells and demonstrates that pial fibroblas...

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Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of th...

Nieto et al. profile cerebrospinal fluid cells in leptomeningeal disease across tumor entities and compare them with blood and tissue lesions using single-cell and spatial approaches, showing that the...

PhD Student (gn*) Neuro-Immunology

Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity...

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

The NOMIS Foundation, in collaboration with the DFG-funded Munich Cluster for Systems Neurology (SyNergy), invites exceptional early-career scientists from around the world to apply for elite…