Streptococcal meningoencephalitis disrupts homeostatic, skull bone marrow–derived monocyte and macrophage trajectories in the dura.

Kupffer cells (KCs), the prenatally seeded macrophages of the liver, show unique functional and immunophenotypic features among tissue-resident macrophages. They are considered as terminally different...

Seminars run on the first Thursday of every month at 16:00 CET. We kick off with a 15-minute spotlight talk from an early-career researcher, then a senior scientist takes the stage for a deeper dive, ...

Macrophages play a central role in tuberculosis, both in bacterial persistence and tissue pathology. Body weight and a dysregulated lipid metabolism profoundly affect disease progression and survival....

Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.

ObjectivesInfections with non-tuberculous mycobacteria (NTM) in children usually affect the lymph nodes and surrounding tissue. Although the infection is typ...

To investigate the intermediate-term health impacts of pediatric inflammatory multisystem syndrome temporally-associated with SARS-CoV-2 (PIMS-TS).Usi…

Dermal macrophages (macs) protect the skin from invading pathogens. They are derived from embryonic as well as hematopoietic progenitors. However, the functional impact of their diverse origin and the...