Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity...

In this perspective, Zagozewski et al. summarize current knowledge about the primitive neurodevelopmental programs that drive medulloblastoma progression. The authors also highlight the unmet needs in...

The Li lab mapped molecularly distinct Purkinje cell (PC) subtypes in 3D and linked them to adult cerebellar architecture. They found that Foxp1/Foxp2 are essential for PC diversity and that Foxp1+ PC...

While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

Brain-wide birthdate mapping reveals that while hindbrain neurogenesis is transient, forebrain neurogenesis is temporally sustained through spatiotemporal regulation of progenitor mitochondrial functi...

The cerebellar ventricular zone (VZ) is the primary source of progenitors that generate cerebellar GABAergic neurons, including Purkinje cells (PCs...

A comparative study of Purkinje dendrite morphology, input arrangement, and regional subtype distribution shows human cells evade constraint by cortical thickness to be both quantitatively and qualita...

Human accelerated regions (HARs) have been implicated in human brain evolution with limited understanding of the biological processes they alter. This study reports that HARs influenced brain evolutio...

If every person in the neuroscience community committed to doing one thing, imagine the cumulative difference it would make.

Analysis of medulloblastomas in humans and mice shows that the functional consequences of ZIC1 mutations are exquisitely dependent on the cells of origin that give rise to different subgroups of medul...

Nature Neuroscience - Brain function requires the formation of diverse and specific synapses. The authors show that the molecular code specifying excitatory connectivity on Purkinje cells evolves...

Nature Protocols - Generation and long-term culture of a human pluripotent stem cell-derived human cerebellar organoid model, which successfully replicates the cellular diversity of the fetal...

Human cortical neurons undergo a protracted period of postmitotic maturation compared with those of other species. Wallace and Pollen review the cell-intrinsic and cell-extrinsic mechanisms that gover...

Libé-Philippot et al. investigate the mechanisms underlying the prolonged synaptic development characteristic of human cortical neurons. They demonstrate that the human-specific genes SRGAP2B/C are re...