Scientific breakthroughs begin with investments in promising researchers. Congratulations to the 2026 cohort of King Trust Postdoctoral Fellowship Program Awardees, who will receive two years of fund...

How tumour cells survive defective homologous recombination (HR) DNA repair has not been fully understood. Here the authors find that PUM3 prevents transcription replication conflicts and…

To cope with the threat of genome instability, cells have evolved an intricate network of mechanisms ranging from cell cycle checkpoints to specialized DNA repair pathways known as the DNA damage res…

Join us at the Keystone Symposia on DNA Replication: Pathway Crosstalk Shaping Physiology and Disease, April 2027, in London, with field leaders!

To cope with the threat of genome instability, cells have evolved an intricate network of mechanisms ranging from cell cycle checkpoints to specialized DNA repair pathways known as the DNA damage res…

Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome...

La recherche demande du temps. Elle demande aussi que des chercheurs puissent prendre des risques, suivre une intuition dont ils ne connaissent pas nécessairement l’issue et, parfois même, se tromper....

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A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

We present a foldamer strategy to downsize the histone H3-H4 quaternary structure into high-affinity, medium-sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide-oligourea chimeras, des....

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

CENP-B escapes the centromere and plays a surprising role in gene regulation

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The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

Découvrez les dernières actualités de l'Institut Curie.

DEAD box helicases DDX17 and DDX5 control transcription termination and the associated processing of the 3' end of pre-messenger RNAs. Here, we demonstrate that the transcriptional readthrough induced...