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Han Xu

@hanxu-mdacc.bsky.social

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Associate professor at MD Anderson Cancer Center. My lab uses high-throughput CRISPR perturbation screening methods to understand protein functions and their roles in cancer.

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Reposted by Han Xu

Nature @nature.com · 12/04/2025

Nature research paper: Comprehensive interrogation of synthetic lethality in the DNA damage response go.nature.com/42878AI

Comprehensive interrogation of synthetic lethality in the DNA damage response - Nature

Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under-replication and SMARCAL1 and FANCM in remodelling persistent cruciform DNA structures.