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The Downs Lab

@thedownslab.bsky.social
926 followers 437 following 30 posts

The Downs lab at the Institute of Cancer Research in London, studying chromatin biology and genome stability. thedownslab.org

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Alex Radzisheuskaya @a-radzisheuskaya.bsky.social · 11/09/2026
We’re hiring! 🧬 We're looking for a Postdoctoral Training Fellow to join our group at the ICR in London and work on chromatin biology, transcription regulation and AML. Curious about how histone modifications shape gene regulation and cell identity? Come join us! jobs.icr.ac.uk/vacancies/15...
jobs.icr.ac.uk
Postdoctoral Training Fellow - Chromatin Biology and Epigenetics in Chelsea | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Chromatin Biology and Epigenetics vacancy in Chelsea . Salary: Salary range £45,600 - £51,450 per annum. Dependent on re...
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The Downs Lab @thedownslab.bsky.social · 13/07/2026
So nice to see Pierre's @pierrecaron.bsky.social highlight of our preprint (led by @lillianwu.bsky.social ) was selected by @jcellsci.bsky.social to include in their latest issue. Also, what a great initiative - ended up reading them all! prelights.biologists.com/highlights/c...
prelights.biologists.com
CENP-B binds hairpin motifs in chromosome arms influencing gene expression - preLights
CENP-B escapes the centromere and plays a surprising role in gene regulation
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Reposted by The Downs Lab
Derek Lowe @dereklowe.bsky.social · 01/05/2026
Let’s see how this goes over:
science.org
An Open Letter to Jay Bhattacharya
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Basil Greber @bjgreber.bsky.social · 26/04/2026
It's a wrap! Thanks to all the organisers (@haicovanattikum.bsky.social, @titiasixma.bsky.social, @sylvie-noordermeer.bsky.social, @luijsterburglab.bsky.social, @thedownslab.bsky.social, and many others) for assembling this fantastic conference. One of the best meetings I have attended so far!
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Lovorka Stojić @loverna.bsky.social · 25/04/2026
Only few days left to submit an abstract for our second annual QMUL centre for epigenetics meeting in June in London! Deadline 3rd may! Details below
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The Downs Lab @thedownslab.bsky.social · 21/04/2026
@alison-harrod.bsky.social has her wonderful project on SMARCA4 and G quadruplex stability out now in Genome Biology link.springer.com/article/10.1...
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The Downs Lab @thedownslab.bsky.social · 13/04/2026
New preprint from the lab! Our awesome @lillianwu.bsky.social drove this project with contributions from @kezlane.bsky.social @alison-harrod.bsky.social and collaborators @andrea-musacchio.bsky.social @chromatinlab.bsky.social and @claudioalfieri.bsky.social #CENP-B www.biorxiv.org/content/10.6...
biorxiv.org
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The Downs Lab @thedownslab.bsky.social · 10/04/2026
The little one heading back to Uni after Easter break. (When does this get easier? 💔)
My son walking out of door carrying luggage
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Reposted by The Downs Lab
Alison Harrod @alison-harrod.bsky.social · 05/12/2025
Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social
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Karen Lane @kezlane.bsky.social · 05/12/2025
Some Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!
royalsocietypublishing.org
Boundary issues: SWI/SNF shapes chromatin patterns in and around centromeres
Abstract. The SWI/SNF family of chromatin remodelling complexes, comprising BAF, PBAF and ncBAF, is known for their critical roles in regulating chromatin
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Ronan Broderick @brodericklab.bsky.social · 19/11/2025
My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT). Informal enquiries to r.a.broderick@bham.ac.uk APPLICATION LINK: sits.bham.ac.uk/urd/sits.urd...
sits.bham.ac.uk
IPP login screen
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The Downs Lab @thedownslab.bsky.social · 30/10/2025
The amazing @lillianwu.bsky.social is now the amazing Dr Lillian Wu 🎉 She passed her viva with flying colours. Massive thanks to her wonderful examiners @esashilab.bsky.social and @viji-draviam.bsky.social
Lillian Wu with her examiners Viji Draviam and Fumiko Esashi
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The Downs Lab @thedownslab.bsky.social · 27/10/2025
Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall
Photo of the London Guildhall
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Aga Gambus @agagambus.bsky.social · 07/10/2025
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...
jobs.ac.uk
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
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Rob Schneider @robertife.bsky.social · 22/09/2025
#Jobalert 🚨: Please RT ! Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism: How do (nuclear) metabolic enzymes reguate chromatin function ? #epigenomics, #epigenetics, #metabolism www.helmholtz-munich.de/en/ife/job-o...
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puckknipscheer.bsky.social @puckknipscheer.bsky.social · 19/09/2025
Are you interested in working on related projects? 🌱 The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position. Apply here: www.hubrecht.eu/jobs
hubrecht.eu
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Di Antonio Research Group @diantoniogroup.bsky.social · 18/09/2025
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇 www.imperial.ac.uk/jobs/search-...
imperial.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Reposted by The Downs Lab
Alexis Barr @alexisbarr.bsky.social · 18/09/2025
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...
imperial.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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The Downs Lab @thedownslab.bsky.social · 16/09/2025
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs www.cell.com/cell-reports...
cell.com
ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
The ARID1A subunit of the BAF chromatin remodeling complex is frequently mutated in cancer. Simões-Sousa et al. demonstrate that ARID1A promotes the assembly of repair factors on chromatin and promote...
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Reposted by The Downs Lab
Christian Zierhut @zierlab.bsky.social · 26/08/2025
Great story from our fantastic neighbour Jörg Mansfeld!
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The Downs Lab @thedownslab.bsky.social · 25/08/2025
Beautiful #pyrenees 😍. Totally refreshed and decompressed. Wonder how long that will last....
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The Downs Lab @thedownslab.bsky.social · 18/07/2025
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
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The Downs Lab @thedownslab.bsky.social · 04/07/2025
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
photo of Alison giving a seminar
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ME Torres-Padilla @metorrespadilla.bsky.social · 12/06/2025
Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum www.helmholtz-munich.de/en/stem-cell... Peer-networking / Career orientation and more !!! Please distribute :) 🙂
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The Downs Lab @thedownslab.bsky.social · 27/05/2025
New preprint from the lab on ARID1A, G quadruplexes, and repair: www.biorxiv.org/content/10.1...
biorxiv.org
ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...
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Reposted by The Downs Lab
Helfrid Hochegger @helfridh.bsky.social · 21/05/2025
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms Please forward to prospective students! Thank you url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
url.uk.m.mimecastprotect.com
PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex
At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.
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Luijsterburglab @luijsterburglab.bsky.social · 09/04/2025
A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com
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The Groth lab @grothlab.bsky.social · 12/02/2025
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
tinyurl.com
6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
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Teif lab @teiflab.bsky.social · 27/03/2025
We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025
jobs.ac.uk
Senior Research Officer at University of Essex
Searching for an academic job? Explore this Senior Research Officer opening on jobs.ac.uk! Click to view more details and browse other academic jobs.
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The Downs Lab @thedownslab.bsky.social · 19/03/2025
Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...
magazine.eacr.org
Nobel prize-winning technology in cancer care - The Cancer Researcher
Katalin Karikó's work into mRNA vaccines
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stapleslab.bsky.social @stapleslab.bsky.social · 12/03/2025
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info
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The Downs Lab @thedownslab.bsky.social · 05/03/2025
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
nature.com
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
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Reposted by The Downs Lab
editorkatie.bsky.social @editorkatie.bsky.social · 26/02/2025
Happy to finally share this paper from our lab! First authors @kezlane.bsky.social @alison-harrod.bsky.social and the team worked so hard on it, I'm proud to be on it too! PBAF as the protector of centromere and pericentromere integrity🧬🔬 @thedownslab.bsky.social www.nature.com/articles/s41...
nature.com
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
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The Downs Lab @thedownslab.bsky.social · 05/03/2025
These are two awesome, talented postdocs! Lucky to have them in the lab 😍
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The Downs Lab @thedownslab.bsky.social · 05/03/2025
Congratulations @kezlane.bsky.social and @alison-harrod.bsky.social and thanks to all our fabulous collaborators!
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 05/02/2025
We're pleased to announce that Katie Begg is the second recipient of an EACR-Molecular Oncology Editorial Fellowship! Learn more about Katie and this exciting opportunity: magazine.eacr.org/katie-begg-r...
magazine.eacr.org
Katie Begg receives EACR-Molecular Oncology Editorial Fellowship - The Cancer Researcher
Katie Begg is the recipient of an EACR-Molecular Oncology Editorial Fellowship, including a placement with the Molecular Oncology journal.
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Ronan Broderick @brodericklab.bsky.social · 31/01/2025
My lab is #hiring! I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism. www.jobs.ac.uk/job/DLO693/r... www.jobs.ac.uk/job/DLP016/r... #Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
jobs.ac.uk
Research Fellow at University of Birmingham
Discover an exciting academic career path as a Research Fellow at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
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Reposted by The Downs Lab
Nora Verlaine @noraverlaine.bsky.social · 24/12/2024
“Women are asked more questions during a seminar and the questions asked of women presenters are more likely to be patronizing or hostile. These effects are not due to women presenting in different fields, different seminar series, or different topics…” www.nber.org/papers/w28494
nber.org
Gender and the Dynamics of Economics Seminars
Founded in 1920, the NBER is a private, non-profit, non-partisan organization dedicated to conducting economic research and to disseminating research findings among academics, public policy makers, an...
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Haico van Attikum @haicovanattikum.bsky.social · 27/12/2024
Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025.
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The Downs Lab @thedownslab.bsky.social · 13/12/2024
We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10... It's a great team and a wonderful place to work!
jobs.icr.ac.uk
Scientific Officer - Epigenetics and Genome Stability in Chelsea | The Institute of Cancer Research
View details and apply for this Scientific Officer - Epigenetics and Genome Stability vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and exp...
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VickySanzMoreno @vickysanzmoreno.bsky.social · 04/12/2024
We are offering a very exciting PhD project 🤩-Project 2- in this great training program! @icrlondon.bsky.social @imperialcollegeldn.bsky.social @crukconvergence.bsky.social Please share 😊 ! Design of advanced therapeutics against metastasis👇 www.convergencesciencecentre.ac.uk/training/con...
convergencesciencecentre.ac.uk
Convergence science PhD - Black in Cancer Students
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keithcaldecott.bsky.social @keithcaldecott.bsky.social · 03/12/2024
Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk
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The Downs Lab @thedownslab.bsky.social · 30/11/2024
Lab retreat 2024! We had days of excellent science, food, ideas, food, games, food, discussions, food, and brainstorming. And snacks.
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Ben Bellenie @chemb.bsky.social · 21/11/2024
Our Centre for Target Validation is there to help translate the amazing depth of knowledge of cancer biology into new drug discovery projects, and we are looking for the right person to lead this. jobs.icr.ac.uk/vacancies/47...
jobs.icr.ac.uk
Head of Biology and Director, Centre for Target Validation (Group Leader) in Sutton | The Institute of Cancer Research
View details and apply for this Head of Biology and Director, Centre for Target Validation (Group Leader) vacancy in Sutton. Competitive Starting Salary Tenure : Appointments will be mad...
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Ben Bellenie @chemb.bsky.social · 21/11/2024
We also have a superb in house DMPK group who work across our preclinical and clinical projects. They are growing and looking for a new team member to support our drug discovery work: jobs.icr.ac.uk/vacancies/10...
jobs.icr.ac.uk
Higher Scientific Officer - Drug Metabolism and Pharmacokinetics in Sutton | The Institute of Cancer Research
View details and apply for this Higher Scientific Officer - Drug Metabolism and Pharmacokinetics vacancy in Sutton. Salary : £37,050 - £39,000 per annum. Commencement on the salary range is ...
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The Downs Lab @thedownslab.bsky.social · 20/11/2024
Each year on our lab retreat, we have dinner discussions on topics of interest. In the weeks leading up to the retreat, lab members vote for their favourites, and we pick a few. This year, @kezlane.bsky.social outdid herself putting together the excel spreadsheet for voting.
screen shot of excel sheet with list of topics and memes for each
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The Downs Lab @thedownslab.bsky.social · 15/11/2024
Had the inaugural Brighton chromatin and genome stability coffee club this morning with Evi Soutoglou and @humphreylab.bsky.social. Nice to discuss science with these two!
photo of 3 people
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Tatiana Moiseeva @tat1anamoiseeva.bsky.social · 12/11/2024
ok, I tried to make a starter pack on genome stability/DNA replication/DNA repair etc. Sorry if I couldn't find someone, please nominate yourself and your colleagues in comments or DMs, looking forward to connecting with everyone! go.bsky.app/9jdDNxG
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Susan Gasser @susanmgasser.bsky.social · 13/08/2024
Delighted to share my Current Opinions review on nucleosome remodelers in DNA repair, co-authored with Jessica Downs: an uptodate survey of R-loops, 3D organization and remodelers especially jn DSB repair. Enjoy! article link: authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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